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学科主题临床医学
The renal histopathological spectrum of patients with nephrotic syndrome: an analysis of 1523 patients in a single Chinese centre
Zhou, Fu-de; Shen, Hai-yan; Chen, Min1; Liu, Gang; Zou, Wan-zhong; Zhao, Ming-hui; Wang, Hai-yan
关键词histopathology idiopathic membranous nephropathy lupus nephritis minimal change disease nephrotic syndrome
刊名NEPHROLOGY DIALYSIS TRANSPLANTATION
2011-12-01
DOI10.1093/ndt/gfr166
26期:12页:3993-3997
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Transplantation ; Urology & Nephrology
研究领域[WOS]Transplantation ; Urology & Nephrology
关键词[WOS]FOCAL SEGMENTAL GLOMERULOSCLEROSIS ; PATHOLOGICAL FEATURES ; NEPHROPATHY ; DISEASES ; GLOMERULONEPHRITIS ; EPIDEMIOLOGY ; NATIONWIDE ; NEPHRITIS ; PROGNOSIS
英文摘要

Background. Nephrotic syndrome is caused by a variety of glomerulopathy. The current study investigated the renal histopathological spectrum of patients with nephrotic syndrome who received a renal biopsy in our department within the last 15 years.

Methods. One thousand five hundred and twenty-three consecutive patients (>= 14 years old at renal biopsy) with nephrotic syndrome were recruited. Patients were divided into four groups according to age at the time of renal biopsy. The renal histopathological spectrum was also compared between nephrotic-range proteinuria patients with and without hypoalbuminaemia.

Results. Among the 1523 patients, the most common cause of nephrotic syndrome was idiopathic membranous nephropathy (IMN) (20.7%), followed by minimal change disease (MCD) (20.4%). Among the patients aged 14-24, 25-44, 45-59 and >= 60 years, the most common cause of nephrotic syndrome was MCD (33.0%), lupus nephritis (LN) (23.0%), IMN (37.9%) and IMN (42.3%), respectively. Among the female patients aged 14-24 and 25-44 years, LN was the leading cause of nephrotic syndrome (35.8 and 36.2%, respectively). The proportion of patients with renal amyloidosis increased in parallel with patient age. The comparison between nephrotic patients with and without hypoalbuminaemia suggests that patients with MCD, LN or renal amyloidosis were more likely to develop hypoalbuminaemia.

Conclusions. The renal histopathological spectrum of nephrotic syndrome differs between ages. MCD, LN and IMN were the main cause of nephrotic syndrome among younger patients, and IMN was the main cause of nephrotic syndrome among older patients. The proportion of patients with renal amyloidosis increased in parallel with patient age.

语种英语
WOS记录号WOS:000297404000026
项目编号30972733
资助机构National Natural Science Fund
引用统计
被引频次:14[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63257
专题北京大学第一临床医学院_肾脏内科
作者单位1.Peking Univ, Inst Nephrol, Beijing 100871, Peoples R China
2.Minist Hlth China, Key Lab Renal Dis, Beijing, Peoples R China
3.Peking Univ, Hosp 1, Dept Med, Div Renal, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Zhou, Fu-de,Shen, Hai-yan,Chen, Min,et al. The renal histopathological spectrum of patients with nephrotic syndrome: an analysis of 1523 patients in a single Chinese centre[J]. NEPHROLOGY DIALYSIS TRANSPLANTATION,2011,26(12):3993-3997.
APA Zhou, Fu-de.,Shen, Hai-yan.,Chen, Min.,Liu, Gang.,Zou, Wan-zhong.,...&Wang, Hai-yan.(2011).The renal histopathological spectrum of patients with nephrotic syndrome: an analysis of 1523 patients in a single Chinese centre.NEPHROLOGY DIALYSIS TRANSPLANTATION,26(12),3993-3997.
MLA Zhou, Fu-de,et al."The renal histopathological spectrum of patients with nephrotic syndrome: an analysis of 1523 patients in a single Chinese centre".NEPHROLOGY DIALYSIS TRANSPLANTATION 26.12(2011):3993-3997.
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