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学科主题: 临床医学
题名:
A genome-wide association study in Han Chinese identifies multiple susceptibility loci for IgA nephropathy
作者: Yu, Xue-Qing1,2; Li, Ming1,2; Zhang, Hong3; Low, Hui-Qi4; Wei, Xin1,2; Wang, Jin-Quan5; Sun, Liang-Dan6,7,8; Sim, Kar-Seng4; Li, Yi4; Foo, Jia-Nee4; Wang, Wei1,2; Li, Zhi-Jian1,2; Yin, Xian-Yong6,7,8; Tang, Xue-Qing1,2; Fan, Li1,2; Chen, Jian9; Li, Rong-Shan10; Wan, Jian-Xin11; Liu, Zhang-Suo12; Lou, Tan-Qi13; Zhu, Li3; Huang, Xiao-Jun14; Zhang, Xue-Jun6,7,8; Liu, Zhi-Hong5; Liu, Jian-Jun4,15
刊名: NATURE GENETICS
发表日期: 2012-02-01
DOI: 10.1038/ng.1047
卷: 44, 期:2, 页:178-182
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Genetics & Heredity
研究领域[WOS]: Genetics & Heredity
关键词[WOS]: IMMUNOGLOBULIN-A NEPHROPATHY ; GENETIC-FACTORS ; URINARY LEVELS ; B-CELL ; HLA ; GLOMERULONEPHRITIS ; ALLELES ; APRIL ; PROGRESSION ; HAPLOTYPES
英文摘要:

We performed a two-stage genome-wide association study of IgA nephropathy (IgAN) in Han Chinese, with 1,434 affected individuals (cases) and 4,270 controls in the discovery phase and follow-up of the top 61 SNPs in an additional 2,703 cases and 3,464 controls. We identified associations at 17p13 (rs3803800, P = 9.40 x 10(-11), OR = 1.21; rs4227, P = 4.31 x 10(-10), OR = 1.23) and 8p23 (rs2738048, P = 3.18 x 10(-14), OR = 0.79) that implicated the genes encoding tumor necrosis factor (TNFSF13) and alpha-defensin (DEFA) as susceptibility genes. In addition, we found multiple associations in the major histocompatibility complex (MHC) region (rs660895, P = 4.13 x 10(-20), OR = 1.34; rs1794275, P = 3.43 x 10(-13), OR = 1.30; rs2523946, P = 1.74 x 10(-11), OR = 1.21) and confirmed a previously reported association at 22q12 (rs12537, P = 1.17 x 10(-11), OR = 0.78). We also found that rs660895 was associated with clinical subtypes of IgAN (P = 0.003), proteinuria (P = 0.025) and IgA levels (P = 0.047). Our findings show that IgAN is associated with variants near genes involved in innate immunity and inflammation.

语种: 英语
所属项目编号: 2012CB517700-2012CB517706 ; 81130012 ; 30925019
项目资助者: Major State Basic Research Development Program of China (973 program) ; National Natural Science Foundation of China ; National Natural Science Foundation of China for Distinguished Young Scholars ; Agency for Science &amp ; Technology and Research of Singapore (A*STAR)
WOS记录号: WOS:000299664400016
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63258
Appears in Collections:北京大学第一临床医学院_肾脏内科_期刊论文

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作者单位: 1.Genome Inst Singapore, Singapore, Singapore
2.Minist Hlth, Key Lab Nephrol, Guangzhou, Guangdong, Peoples R China
3.Sun Yat Sen Univ, Affiliated Hosp 1, Dept Nephrol, Guangzhou 510275, Guangdong, Peoples R China
4.Peking Univ, Hosp 1, Renal Div, Inst Nephrol, Beijing 100871, Peoples R China
5.Nanjing Mil Command, Nanjing Gen Hosp, Dept Nephrol, Nanjing, Jiangsu, Peoples R China
6.Anhui Med Univ, Hosp 1, Inst Dermatol, Hefei, Anhui, Peoples R China
7.Anhui Med Univ, Hosp 1, Dept Dermatol, Hefei, Anhui, Peoples R China
8.Minist Natl Sci & Technol, State Key Lab Incubat Base Dermatol, Hefei, Anhui, Peoples R China
9.Nanjing Mil Command, Fuzhou Gen Hosp, Dept Nephrol, Fuzhou, Fujian, Peoples R China
10.Shanxi Med Univ, Hosp 2, Dept Nephrol, Taiyuan, Shanxi, Peoples R China
11.Fujian Med Univ, Affiliated Hosp 1, Dept Nephrol, Fuzhou, Fujian, Peoples R China
12.Zhengzhou Univ, Affiliated Hosp 1, Dept Nephrol, Zhengzhou, Henan, Peoples R China
13.Sun Yat Sen Univ, Affiliated Hosp 3, Dept Nephrol, Guangzhou 510275, Guangdong, Peoples R China
14.Peking Univ, Peoples Hosp, Dept Hematol, Beijing 100871, Peoples R China
15.Anhui Med Univ, Sch Life Sci, Hefei, Anhui, Peoples R China

Recommended Citation:
Yu, Xue-Qing,Li, Ming,Zhang, Hong,et al. A genome-wide association study in Han Chinese identifies multiple susceptibility loci for IgA nephropathy[J]. NATURE GENETICS,2012,44(2):178-182.
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