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学科主题临床医学
A multicentre, prospective, randomized trial: comparative efficacy of tamsulosin and nifedipine in medical expulsive therapy for distal ureteric stones with renal colic
Ye, Zhangqun1; Yang, Huan1; Li, Hong2; Zhang, Xiaochun3; Deng, Yaoliang4; Zeng, Guohua5; Chen, Lingwu6; Cheng, Yue7; Yang, Jianggen8; Mi, Qiwu9; Zhang, Yonghai10; Chen, Zhong1; Guo, Hui; He, Wei1; Chen, Zhiqiang1
关键词alpha-adrenoceptor antagonists calcium-channel blockers medical expulsive therapy patients trial ureteric stones
刊名BJU INTERNATIONAL
2011-07-01
DOI10.1111/j.1464-410X.2010.09801.x
108期:2页:276-279
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Urology & Nephrology
研究领域[WOS]Urology & Nephrology
关键词[WOS]SHOCK-WAVE LITHOTRIPSY ; MANAGEMENT ; CALCULI
英文摘要

OBJECTIVE

To determine the comparative efficacy of tamsulosin and nifedipine in medical expulsive therapy (MET) for distal ureteric stones with renal colic.

PATIENTS AND METHODS

We evaluated the comparative efficacy of tamsulosin and nifedipine in MET in a prospective randomized trial of 3189 outpatients from 10 centres in China.

Eligible patients randomly received tamsulosin or nifedipine. Efficacies of the two agents in MET were compared at 4 weeks.

The primary endpoint was overall stone-expulsion rate.

Secondary endpoints were stone-expulsion time, rate of pain relief therapy, mean analgesic consumption for renal colic recurrence, and side-effects incidence.

RESULTS

Stone-expulsion rates in the tamsulosin group (group 1) were greater than those in the nifedipine group (group 2; P < 0.01).

There was a significant variation in stone-expulsion rates and times between groups 1 and 2 (P < 0.01); with improvements in stone-expulsion rate and time significantly better in group 1 than in group 2.

There was a significant variation in the rate of pain relief therapy for renal colic recurrence between groups 1 and 2 (P < 0.01); patients in group 1 required significantly less analgesics than those in group 2 (P < 0.01).

There were no statistically significant differences in side-effects incidence between the groups.

CONCLUSIONS

Administration of tamsulosin and nifedipine in MET was determined to be safe and effective for distal ureteric stones with renal colic.

Tamsulosin was significantly better than nifedipine in relieving renal colic and facilitating ureteric stone expulsion.

语种英语
WOS记录号WOS:000292328800030
资助机构Astellas Pharmaceutical
引用统计
被引频次:32[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63261
专题北京大学第一临床医学院
作者单位1.Huazhong Univ Sci & Technol, Tongji Hosp, Div Urol, Tongji Med Coll, Wuhan 430030, HuBei, Peoples R China
2.Sichuan Univ, W China Hosp, Chengdu 610064, Peoples R China
3.Peking Univ, Hosp 1, Beijing, Peoples R China
4.Guangxi Med Univ, Affiliated Hosp 1, Nanning, Peoples R China
5.Guangzhou Med Coll, Affiliated Hosp 1, Guangzhou, Guangdong, Peoples R China
6.Jinan Univ, Affliated Hosp 2, Shenzhen, Peoples R China
7.Dongguan Peoples Hosp, Dongguan, South Korea
8.Sun Yat Sen Univ, Shantou Hosp, Shantou, Peoples R China
9.Sun Yat Sen Univ, Affiliated Hosp 1, Guangzhou 510275, Guangdong, Peoples R China
10.Ningbo Univ, Sch Med, Hosp Ningbo 1, Ningbo 315211, Zhejiang, Peoples R China
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GB/T 7714
Ye, Zhangqun,Yang, Huan,Li, Hong,et al. A multicentre, prospective, randomized trial: comparative efficacy of tamsulosin and nifedipine in medical expulsive therapy for distal ureteric stones with renal colic[J]. BJU INTERNATIONAL,2011,108(2):276-279.
APA Ye, Zhangqun.,Yang, Huan.,Li, Hong.,Zhang, Xiaochun.,Deng, Yaoliang.,...&Chen, Zhiqiang.(2011).A multicentre, prospective, randomized trial: comparative efficacy of tamsulosin and nifedipine in medical expulsive therapy for distal ureteric stones with renal colic.BJU INTERNATIONAL,108(2),276-279.
MLA Ye, Zhangqun,et al."A multicentre, prospective, randomized trial: comparative efficacy of tamsulosin and nifedipine in medical expulsive therapy for distal ureteric stones with renal colic".BJU INTERNATIONAL 108.2(2011):276-279.
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