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学科主题: 临床医学
题名:
A multicentre, prospective, randomized trial: comparative efficacy of tamsulosin and nifedipine in medical expulsive therapy for distal ureteric stones with renal colic
作者: Ye, Zhangqun1; Yang, Huan1; Li, Hong2; Zhang, Xiaochun3; Deng, Yaoliang4; Zeng, Guohua5; Chen, Lingwu6; Cheng, Yue7; Yang, Jianggen8; Mi, Qiwu9; Zhang, Yonghai10; Chen, Zhong1; Guo, Hui; He, Wei1; Chen, Zhiqiang1
关键词: alpha-adrenoceptor antagonists ; calcium-channel blockers ; medical expulsive therapy ; patients ; trial ; ureteric stones
刊名: BJU INTERNATIONAL
发表日期: 2011-07-01
DOI: 10.1111/j.1464-410X.2010.09801.x
卷: 108, 期:2, 页:276-279
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Urology & Nephrology
研究领域[WOS]: Urology & Nephrology
关键词[WOS]: SHOCK-WAVE LITHOTRIPSY ; MANAGEMENT ; CALCULI
英文摘要:

OBJECTIVE

To determine the comparative efficacy of tamsulosin and nifedipine in medical expulsive therapy (MET) for distal ureteric stones with renal colic.

PATIENTS AND METHODS

We evaluated the comparative efficacy of tamsulosin and nifedipine in MET in a prospective randomized trial of 3189 outpatients from 10 centres in China.

Eligible patients randomly received tamsulosin or nifedipine. Efficacies of the two agents in MET were compared at 4 weeks.

The primary endpoint was overall stone-expulsion rate.

Secondary endpoints were stone-expulsion time, rate of pain relief therapy, mean analgesic consumption for renal colic recurrence, and side-effects incidence.

RESULTS

Stone-expulsion rates in the tamsulosin group (group 1) were greater than those in the nifedipine group (group 2; P < 0.01).

There was a significant variation in stone-expulsion rates and times between groups 1 and 2 (P < 0.01); with improvements in stone-expulsion rate and time significantly better in group 1 than in group 2.

There was a significant variation in the rate of pain relief therapy for renal colic recurrence between groups 1 and 2 (P < 0.01); patients in group 1 required significantly less analgesics than those in group 2 (P < 0.01).

There were no statistically significant differences in side-effects incidence between the groups.

CONCLUSIONS

Administration of tamsulosin and nifedipine in MET was determined to be safe and effective for distal ureteric stones with renal colic.

Tamsulosin was significantly better than nifedipine in relieving renal colic and facilitating ureteric stone expulsion.

语种: 英语
项目资助者: Astellas Pharmaceutical
WOS记录号: WOS:000292328800030
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63261
Appears in Collections:北京大学第一临床医学院_期刊论文

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作者单位: 1.Huazhong Univ Sci & Technol, Tongji Hosp, Div Urol, Tongji Med Coll, Wuhan 430030, HuBei, Peoples R China
2.Sichuan Univ, W China Hosp, Chengdu 610064, Peoples R China
3.Peking Univ, Hosp 1, Beijing, Peoples R China
4.Guangxi Med Univ, Affiliated Hosp 1, Nanning, Peoples R China
5.Guangzhou Med Coll, Affiliated Hosp 1, Guangzhou, Guangdong, Peoples R China
6.Jinan Univ, Affliated Hosp 2, Shenzhen, Peoples R China
7.Dongguan Peoples Hosp, Dongguan, South Korea
8.Sun Yat Sen Univ, Shantou Hosp, Shantou, Peoples R China
9.Sun Yat Sen Univ, Affiliated Hosp 1, Guangzhou 510275, Guangdong, Peoples R China
10.Ningbo Univ, Sch Med, Hosp Ningbo 1, Ningbo 315211, Zhejiang, Peoples R China

Recommended Citation:
Ye, Zhangqun,Yang, Huan,Li, Hong,et al. A multicentre, prospective, randomized trial: comparative efficacy of tamsulosin and nifedipine in medical expulsive therapy for distal ureteric stones with renal colic[J]. BJU INTERNATIONAL,2011,108(2):276-279.
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