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Destruction of parotid glands affects nitrate and nitrite metabolism
Xia, DS; Deng, DJ; Wang, SL
关键词saliva parotid gland nitrate nitrite miniature pig
刊名JOURNAL OF DENTAL RESEARCH
2003-02-01
82期:2页:101-105
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Dentistry, Oral Surgery & Medicine
研究领域[WOS]Dentistry, Oral Surgery & Medicine
关键词[WOS]DIETARY NITRATE ; GASTRIC-CANCER ; HUMAN SALIVA ; ETIOLOGY
英文摘要

The role of salivary glands in nitrate and nitrite metabolism is poorly understood. The aim of the present study was to investigate the effect of parotid gland ablation on dynamic metabolism of nitrate and nitrite in miniature pigs. The parotid glands of 5 healthy miniature pigs were bilaterally ablated by methyl violet. Concentrations of nitrate and nitrite of whole saliva, serum, and urine samples were analyzed by high-performance liquid chromatography. Results showed that bilateral ablation of the parotid glands led to a significant decrease of nitrate secretion from blood to saliva (P < 0.05) and thus low nitrite levels. Dysfunction of the parotid glands temporarily increased the systemic level of nitrate in miniature pigs after nitrate loading. This study suggests that the parotid glands play an important role in the balance of nitrate and nitrite levels in both whole saliva and the body.

语种英语
WOS记录号WOS:000180672500005
引用统计
被引频次:28[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63262
专题北京大学临床肿瘤学院
作者单位1.Peking Univ, Sch Oncol, Beijing 100034, Peoples R China
2.Beijing Inst Canc Res, Beijing 100034, Peoples R China
3.Capital Univ Med Sci, Salivary Gland Dis Ctr, Fac Stomatol, Beijing 100050, Peoples R China
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Xia, DS,Deng, DJ,Wang, SL. Destruction of parotid glands affects nitrate and nitrite metabolism[J]. JOURNAL OF DENTAL RESEARCH,2003,82(2):101-105.
APA Xia, DS,Deng, DJ,&Wang, SL.(2003).Destruction of parotid glands affects nitrate and nitrite metabolism.JOURNAL OF DENTAL RESEARCH,82(2),101-105.
MLA Xia, DS,et al."Destruction of parotid glands affects nitrate and nitrite metabolism".JOURNAL OF DENTAL RESEARCH 82.2(2003):101-105.
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