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学科主题: 临床医学
题名:
Destruction of parotid glands affects nitrate and nitrite metabolism
作者: Xia, DS; Deng, DJ; Wang, SL
关键词: saliva ; parotid gland ; nitrate ; nitrite ; miniature pig
刊名: JOURNAL OF DENTAL RESEARCH
发表日期: 2003-02-01
卷: 82, 期:2, 页:101-105
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Dentistry, Oral Surgery & Medicine
研究领域[WOS]: Dentistry, Oral Surgery & Medicine
关键词[WOS]: DIETARY NITRATE ; GASTRIC-CANCER ; HUMAN SALIVA ; ETIOLOGY
英文摘要:

The role of salivary glands in nitrate and nitrite metabolism is poorly understood. The aim of the present study was to investigate the effect of parotid gland ablation on dynamic metabolism of nitrate and nitrite in miniature pigs. The parotid glands of 5 healthy miniature pigs were bilaterally ablated by methyl violet. Concentrations of nitrate and nitrite of whole saliva, serum, and urine samples were analyzed by high-performance liquid chromatography. Results showed that bilateral ablation of the parotid glands led to a significant decrease of nitrate secretion from blood to saliva (P < 0.05) and thus low nitrite levels. Dysfunction of the parotid glands temporarily increased the systemic level of nitrate in miniature pigs after nitrate loading. This study suggests that the parotid glands play an important role in the balance of nitrate and nitrite levels in both whole saliva and the body.

语种: 英语
WOS记录号: WOS:000180672500005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63262
Appears in Collections:北京大学临床肿瘤学院_期刊论文

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作者单位: 1.Peking Univ, Sch Oncol, Beijing 100034, Peoples R China
2.Beijing Inst Canc Res, Beijing 100034, Peoples R China
3.Capital Univ Med Sci, Salivary Gland Dis Ctr, Fac Stomatol, Beijing 100050, Peoples R China

Recommended Citation:
Xia, DS,Deng, DJ,Wang, SL. Destruction of parotid glands affects nitrate and nitrite metabolism[J]. JOURNAL OF DENTAL RESEARCH,2003,82(2):101-105.
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