|Relationship among symptoms, mucosal injury, and acid exposure in gastroesophageal reflux disease|
|Xu Ding-ting; Feng Gui-jian; Zhao Li-li; Liu Yu-lan|
|关键词||gastroesophageal reflux disease Reflux Disease Questionnaire pathological acid exposure reflux esophagitis|
|刊名||CHINESE MEDICAL JOURNAL|
|WOS标题词||Science & Technology|
|类目[WOS]||Medicine, General & Internal|
|研究领域[WOS]||General & Internal Medicine|
|关键词[WOS]||NONCARDIAC CHEST-PAIN ; BARRETTS-ESOPHAGUS ; RISK-FACTORS ; PREVALENCE ; POPULATION|
Background Symptoms, endoscopy, and pH monitoring form the basis of diagnosis of gastroesophageal reflux disease (GERD). Their relationship was meaningful for primary care physicians, but still unclear. Our research aimed to compare questionnaire, endoscopy, and pH monitoring and to analyze their correlations.
Methods Three hundred patients who underwent the Reflux Disease Questionnaire (RDQ), endoscopy, and esophageal 24-hour pH monitoring from March 2007 to December 2010 in Peking University People′s Hospital were enrolled. We analyzed the characteristics of different investigations and their relationships.
Results Male (OR for mild reflux esophagitis (RE)=2.433, severe RE=8.386), body mass index (BMI) (OR for mild RE=1.222, severe RE=1.297), and hernia (OR for mild RE=6.059, severe RE=17.547), were found to be the risk factors for RE; age (OR=1.074) was correlated with severe RE. The consistency of questionnaire, endoscopy, and pH monitoring was poor: RDQ did not agree well with pH monitoring (kappa=0.061), nor with endoscopy (kappa=0.044); pH monitoring did not agree well with endoscopy (kappa=0.316). However, the severity of mucosa injury in RE was associated with pathological acid exposure (PAE): reflux episodes of >5 minutes (P=0.035), the percentage time pH <4 (P=0.017), and the DeMeester score (P=0.016) increased significantly in patients with severe RE. Chest pain had poor relationship with RE or PAE.
Conclusions Male, age, BMI, and hernia were probably risk factors for esophagitis. RDQ, endoscopy, and pH monitoring have their own focus and reinforce each other in diagnosis. Of the GERD symptoms, chest pain had negative correlation with RE or PAE.
|作者单位||Peking Univ, Peoples Hosp, Dept Gastroenterol, Beijing 100044, Peoples R China|
|Xu Ding-ting,Feng Gui-jian,Zhao Li-li,et al. Relationship among symptoms, mucosal injury, and acid exposure in gastroesophageal reflux disease[J]. CHINESE MEDICAL JOURNAL,2013,126(23):4430-4434.|
|APA||Xu Ding-ting,Feng Gui-jian,Zhao Li-li,&Liu Yu-lan.(2013).Relationship among symptoms, mucosal injury, and acid exposure in gastroesophageal reflux disease.CHINESE MEDICAL JOURNAL,126(23),4430-4434.|
|MLA||Xu Ding-ting,et al."Relationship among symptoms, mucosal injury, and acid exposure in gastroesophageal reflux disease".CHINESE MEDICAL JOURNAL 126.23(2013):4430-4434.|