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学科主题临床医学
Relationship among symptoms, mucosal injury, and acid exposure in gastroesophageal reflux disease
Xu Ding-ting; Feng Gui-jian; Zhao Li-li; Liu Yu-lan
关键词gastroesophageal reflux disease Reflux Disease Questionnaire pathological acid exposure reflux esophagitis
刊名CHINESE MEDICAL JOURNAL
2013-12-05
DOI10.3760/cma.j.issn.0366-6999.20130559
126期:23页:4430-4434
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
研究领域[WOS]General & Internal Medicine
关键词[WOS]NONCARDIAC CHEST-PAIN ; BARRETTS-ESOPHAGUS ; RISK-FACTORS ; PREVALENCE ; POPULATION
英文摘要

Background Symptoms, endoscopy, and pH monitoring form the basis of diagnosis of gastroesophageal reflux disease (GERD). Their relationship was meaningful for primary care physicians, but still unclear. Our research aimed to compare questionnaire, endoscopy, and pH monitoring and to analyze their correlations.

Methods Three hundred patients who underwent the Reflux Disease Questionnaire (RDQ), endoscopy, and esophageal 24-hour pH monitoring from March 2007 to December 2010 in Peking University People′s Hospital were enrolled. We analyzed the characteristics of different investigations and their relationships.

Results Male (OR for mild reflux esophagitis (RE)=2.433, severe RE=8.386), body mass index (BMI) (OR for mild RE=1.222, severe RE=1.297), and hernia (OR for mild RE=6.059, severe RE=17.547), were found to be the risk factors for RE; age (OR=1.074) was correlated with severe RE. The consistency of questionnaire, endoscopy, and pH monitoring was poor: RDQ did not agree well with pH monitoring (kappa=0.061), nor with endoscopy (kappa=0.044); pH monitoring did not agree well with endoscopy (kappa=0.316). However, the severity of mucosa injury in RE was associated with pathological acid exposure (PAE): reflux episodes of >5 minutes (P=0.035), the percentage time pH <4 (P=0.017), and the DeMeester score (P=0.016) increased significantly in patients with severe RE. Chest pain had poor relationship with RE or PAE.

Conclusions Male, age, BMI, and hernia were probably risk factors for esophagitis. RDQ, endoscopy, and pH monitoring have their own focus and reinforce each other in diagnosis. Of the GERD symptoms, chest pain had negative correlation with RE or PAE.

语种英语
WOS记录号WOS:000329084100005
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63263
专题北京大学第二临床医学院_消化科
北京大学第一临床医学院_妇产科
作者单位Peking Univ, Peoples Hosp, Dept Gastroenterol, Beijing 100044, Peoples R China
推荐引用方式
GB/T 7714
Xu Ding-ting,Feng Gui-jian,Zhao Li-li,et al. Relationship among symptoms, mucosal injury, and acid exposure in gastroesophageal reflux disease[J]. CHINESE MEDICAL JOURNAL,2013,126(23):4430-4434.
APA Xu Ding-ting,Feng Gui-jian,Zhao Li-li,&Liu Yu-lan.(2013).Relationship among symptoms, mucosal injury, and acid exposure in gastroesophageal reflux disease.CHINESE MEDICAL JOURNAL,126(23),4430-4434.
MLA Xu Ding-ting,et al."Relationship among symptoms, mucosal injury, and acid exposure in gastroesophageal reflux disease".CHINESE MEDICAL JOURNAL 126.23(2013):4430-4434.
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