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学科主题: 临床医学
题名:
Enhanced anti-tumor immunity generated by Rituximab-coated tumor cell vaccine
作者: Wang, Huili1,2; Wang, Dongmei1,2; Li, Mengqiang3; Zhou, Chunxia1,2; Ma, Wenbo1,2; Su, Xiaosan1,2; Liu, Rongzhi4; Zhang, Shuren1,2
关键词: Rituximab ; immunotherapy ; dendritic cells ; tumor cell vaccine
刊名: CANCER LETTERS
发表日期: 2008-09-08
DOI: 10.1016/j.canlet.2008.03.042
卷: 268, 期:1, 页:129-136
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: MONOCLONAL-ANTIBODY RITUXIMAB ; DENDRITIC CELLS ; BREAST-CANCER ; ANTIGENS ; LYMPHOMA ; RESPONSES ; EPITOPES ; CD20 ; SPECIFICITY ; MECHANISMS
英文摘要:

Rituximab is a chimeric monoclonal antibody against CD20, and has been used to treat malignant tumors derived from B cell. We designed a tumor cell vaccine modified by Rituximab, and evaluated anti-tumor effect in human CD20 gene transfected mice tumor model in vivo, and in human CTLs induction by mixed lymphocyte tumor cell culture in vitro. The results demonstrated that the Rituximab-coated tumor cell vaccine had a significant therapeutic effect against tumor Pulmonary metastasis formation. Antibody depletion experiments showed CD8+ T Cells were essential for the anti-tumor effect but not NK cells. Capture rate Of tumor cells by DCs, which were detected by flow cytometry, was increased by adding Rituximab. The tumor specific cytolysis could be induced by Rituximab-coated tumor cell in human in vitro assay. This therapeutic strategy provides a simple way to potentialize CTLs function to combat cancer and may promote more clinical consideration in immunotherapy for tumors. Rituximab-coated tumor cell vaccine also expanded the clinical Rituximab applications. (C) 2008 Elsevier Ireland Ltd. All rights reserved.

语种: 英语
项目资助者: Shanxi Provincial cancer hospital and institute in China
WOS记录号: WOS:000260038900015
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63265
Appears in Collections:北京大学第一临床医学院_期刊论文

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作者单位: 1.Peking Univ, Hosp 1, Beijing 100083, Peoples R China
2.Peking Union Med Coll, Inst Canc, Dept Immunol, Beijing 100021, Peoples R China
3.Chinese Acad Med Sci, Beijing 100021, Peoples R China
4.Chinese Acad Sci, Inst Microbiol, Beijing 100101, Peoples R China

Recommended Citation:
Wang, Huili,Wang, Dongmei,Li, Mengqiang,et al. Enhanced anti-tumor immunity generated by Rituximab-coated tumor cell vaccine[J]. CANCER LETTERS,2008,268(1):129-136.
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