IR@PKUHSC  > 北京大学第一临床医学院
学科主题临床医学
Association Between Changes in Air Pollution Levels During the Beijing Olympics and Biomarkers of Inflammation and Thrombosis in Healthy Young Adults
Rich, David Q.2; Kipen, Howard M.3,4; Huang, Wei9,10; Wang, Guangfa11; Wang, Yuedan13; Zhu, Ping12; Ohman-Strickland, Pamela3,6; Hu, Min9,10; Philipp, Claire5; Diehl, Scott R.8; Lu, Shou-En3; Tong, Jian7; Gong, Jicheng1,7,14; Thomas, Duncan1,14; Zhu, Tong9,10; Zhang, Junfeng (Jim)1,3,7,14
刊名JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
2012-05-16
DOI10.1001/jama.2012.3488
307期:19页:2068-2078
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
研究领域[WOS]General & Internal Medicine
关键词[WOS]CASE-CROSSOVER ANALYSIS ; SOLUBLE CD40 LIGAND ; MYOCARDIAL-INFARCTION ; AMBIENT AIR ; P-SELECTIN ; CARDIOVASCULAR-DISEASE ; ATRIAL-FIBRILLATION ; PLATELET ACTIVATION ; OXIDATIVE STRESS ; HEART-DISEASE
英文摘要

Context Air pollution is a risk factor for cardiovascular diseases (CVD), but the underlying biological mechanisms are not well understood.

Objective To determine whether markers related to CVD pathophysiological pathways (biomarkers for systemic inflammation and thrombosis, heart rate, and blood pressure) are sensitive to changes in air pollution.

Design, Setting, and Participants Using a quasi-experimental opportunity offered by greatly restricted air pollution emissions during the Beijing Olympics, we measured pollutants daily and the outcomes listed below in 125 healthy young adults before, during, and after the 2008 Olympics (June 2-October 30). We used linear mixed effects models to estimate the improvement in outcome levels during the Olympics and the anticipated reversal of outcome levels after pollution controls ended to determine whether changes in outcome levels were associated with changes in pollutant concentrations.

Main Outcome Measures C-reactive protein (CRP), fibrinogen, von Willebrand factor, soluble CD40 ligand (sCD40L), soluble P-selectin (sCD62P) concentrations; white blood cell count (WBC); heart rate; and blood pressure.

Results Concentrations of particulate and gaseous pollutants decreased substantially (-13% to -60%) from the pre-Olympic period to the during-Olympic period. Using 2-sided tests conducted at the .003 level, we observed statistically significant improvements in sCD62P levels by -34.0% (95% CI, -38.4% to -29.2%; P<.001) from a pre-Olympic mean of 6.29 ng/mL to a during-Olympic mean of 4.16 ng/mL and von Willebrand factor by -13.1% (95% CI, -18.6% to -7.5%; P<.001) from 106.4% to 92.6%. After adjustments for multiple comparisons, changes in the other outcomes were not statistically significant. In the post-Olympic period when pollutant concentrations increased, most outcomes approximated pre-Olympic levels, but only sCD62P and systolic blood pressure were significantly worsened from the during-Olympic period. The fraction of above-detection-limit values for CRP (percentage >= 0.3 mg/L) was reduced from 55% in the pre-Olympic period to 46% in the during-Olympic period and reduced further to 36% in the post-Olympic period. Interquartile range increases in pollutant concentrations were consistently associated with statistically significant increases in fibrinogen, von Willebrand factor, heart rate, sCD62P, and sCD40L concentrations.

Conclusions Changes in air pollution levels during the Beijing Olympics were associated with acute changes in biomarkers of inflammation and thrombosis and measures of cardiovascular physiology in healthy young persons. These findings are of uncertain clinical significance. JAMA. 2012;307(19):2068-2078

语种英语
WOS记录号WOS:000304048200026
Citation statistics
Cited Times:131[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63269
Collection北京大学第一临床医学院
北京大学基础医学院
北京大学第一临床医学院_呼吸科
作者单位1.Univ So Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90089 USA
2.Univ Rochester, Sch Med & Dent, Dept Community & Prevent Med, Rochester, NY USA
3.Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Environm & Occupat Hlth Sci Inst, Piscataway, NJ 08854 USA
4.Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Dept Environm & Occupat Med, Piscataway, NJ 08854 USA
5.Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Dept Med, Piscataway, NJ 08854 USA
6.Univ Med & Dent New Jersey, Sch Publ Hlth, Dept Biostat, Piscataway, NJ 08854 USA
7.Univ Med & Dent New Jersey, Sch Publ Hlth, Dept Environm Hlth, Piscataway, NJ 08854 USA
8.Univ Med & Dent New Jersey, Sch Dent, Ctr Pharmacogen & Complex Dis, Newark, NJ 07103 USA
9.Peking Univ, Hosp 1, Coll Environm Sci & Engn, State Key Lab Environm Simulat & Pollut Control, Beijing 100871, Peoples R China
10.Peking Univ, Hosp 1, Ctr Environm & Hlth, Beijing 100871, Peoples R China
11.Peking Univ, Hosp 1, Dept Pulm Med, Beijing 100871, Peoples R China
12.Peking Univ, Hosp 1, Dept Hematol, Beijing 100871, Peoples R China
13.Peking Univ, Hlth Sci Ctr, Dept Immunol, Beijing 100871, Peoples R China
14.Univ So Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90033 USA
Recommended Citation
GB/T 7714
Rich, David Q.,Kipen, Howard M.,Huang, Wei,et al. Association Between Changes in Air Pollution Levels During the Beijing Olympics and Biomarkers of Inflammation and Thrombosis in Healthy Young Adults[J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION,2012,307(19):2068-2078.
APA Rich, David Q..,Kipen, Howard M..,Huang, Wei.,Wang, Guangfa.,Wang, Yuedan.,...&Zhang, Junfeng .(2012).Association Between Changes in Air Pollution Levels During the Beijing Olympics and Biomarkers of Inflammation and Thrombosis in Healthy Young Adults.JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION,307(19),2068-2078.
MLA Rich, David Q.,et al."Association Between Changes in Air Pollution Levels During the Beijing Olympics and Biomarkers of Inflammation and Thrombosis in Healthy Young Adults".JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION 307.19(2012):2068-2078.
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