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Long Double-Stranded Multiplex siRNAs for Dual Genes Silencing
Peng, Wei1,2; Chen, Jianxin1; Qin, Yinchao1; Yang, Zhenjun2; Zhu, York Yuanyuan1
刊名NUCLEIC ACID THERAPEUTICS
2013-08-01
DOI10.1089/nat.2013.0416
23期:4页:281-288
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Chemistry, Medicinal ; Medicine, Research & Experimental
研究领域[WOS]Biochemistry & Molecular Biology ; Pharmacology & Pharmacy ; Research & Experimental Medicine
关键词[WOS]MAMMALIAN-CELLS ; CANCER-CELLS ; RNA ; APOPTOSIS ; DUPLEXES ; INHIBITION ; ARGONAUTE2 ; EXPRESSION
英文摘要

Simultaneous suppression of multiple oncogenes is an attractive strategy to treat cancers. Herein we present a series of long double-stranded multiplex small interfering RNAs (multi-siRNAs) that is suitable for dual genes silencing through a sequence-specific RNA interference process without inducing significant immune responses. A gap feature structurally designed in either of the nucleotide strands of the multi-siRNAs was proved to be essential toward silencing target genes and avoiding immune responses. Furthermore, the silencing effect of multi-siRNAs against SURVIVIN and BCL-2 genes was shown to be effective and resulted in up-regulation of caspase-3 related apoptosis and, in turn, inhibition of bladder cancer cell proliferation. Our observation suggested that the rationally designed multi-siRNAs would have great potential for therapeutic siRNA design.

语种英语
WOS记录号WOS:000322596100006
项目编号1001052C ; AS2010010
资助机构Postdoctoral Sustentation Foundation of Jiangsu Province, China ; Medicine Program of Nantong Science and Technology Bureau, China
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63278
专题北京大学药学院
北京大学临床肿瘤学院_人力资源处
作者单位1.Biom Biotechnol Co Ltd, Nantong 226016, Jiangsu, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100871, Peoples R China
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GB/T 7714
Peng, Wei,Chen, Jianxin,Qin, Yinchao,et al. Long Double-Stranded Multiplex siRNAs for Dual Genes Silencing[J]. NUCLEIC ACID THERAPEUTICS,2013,23(4):281-288.
APA Peng, Wei,Chen, Jianxin,Qin, Yinchao,Yang, Zhenjun,&Zhu, York Yuanyuan.(2013).Long Double-Stranded Multiplex siRNAs for Dual Genes Silencing.NUCLEIC ACID THERAPEUTICS,23(4),281-288.
MLA Peng, Wei,et al."Long Double-Stranded Multiplex siRNAs for Dual Genes Silencing".NUCLEIC ACID THERAPEUTICS 23.4(2013):281-288.
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