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Bis(acetylacetonato)-oxovanadium(IV), bis(maltolato)-oxovanadium(IV) and sodium metavanadate induce antilipolytic effects by regulating hormone-sensitive lipase and perilipin via activation of Akt
Liu, Jing-Cheng1,2; Yu, You2; Wang, Gang2; Wang, Kui1,2; Yang, Xiao-Gai2
刊名METALLOMICS
2013
DOI10.1039/c3mt00001j
5期:7页:813-820
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology
资助者National Natural Science Foundation of China ; National Natural Science Foundation of China
研究领域[WOS]Biochemistry & Molecular Biology
关键词[WOS]HUMAN ADIPOSE-TISSUE ; LIPID-METABOLISM ; ADIPOCYTE DIFFERENTIATION ; FATTY-ACIDS ; KINASE-B ; INSULIN ; LIPOLYSIS ; VANADATE ; CELL ; PHOSPHORYLATION
英文摘要

The increased plasma free fatty acid levels due to the deregulated lipolysis in adipocytes are considered as one of the major risk factors for developing type II diabetes. Vanadium compounds are well-known for their antidiabetic effects both on glucose and lipid metabolism, but the mechanisms are still not completely understood. The present study suggests a mechanism for how vanadium compounds exert antilipolytic effects. It demonstrates that all the three vanadium compounds, bis(acetylacetonato)-oxovanadium(IV) (VO(acac)(2)), bis(maltolato)-oxovanadium(IV) (VO(ma)(2)) and sodium metavanadate (NaVO3), attenuated basal lipolysis in 3T3L1 adipocytes in a dose- (from 100 to 400 mu M for VO(acac)(2) and VO(ma)(2), 1.0 to 4.0 mM for vanadate) and time-dependent (from 0.5 to 4 h) manner using the glycerol release as a marker of lipolysis. In addition, the three compounds inhibited lipolysis to a different extent. Among them, VO(acac)(2) (from 100 to 400 mu M) exerted the most potent effect and reduced the lipolysis to similar to 60-20% of control after 4 h treatment. The antilipolytic effects of vanadium compounds were further evidenced by a decrease of the levels of phosphorylated HSL at Ser660 and phosphorylated perilipin, which were counteracted by inhibitors of PI3K or Akt but not by an MEK inhibitor. This indicates that though both Akt and ERK pathways are activated by the vanadium compounds, only Akt activation contributes to the antilipolytic effect of the vanadium compounds, without the involvement of ERK activation. We previously demonstrated that VO(acac)(2) can block cell cycle progression at the G1/S phase via a highly activated ERK signal in human hepatoma HepG2 cells. Together with this study, we show that similar activated pathways may lead to differential biological consequences for cancer cells and adipocytes, indicating that vanadium compounds may be used in the prevention and treatment of both diabetes and cancer.

语种英语
所属项目编号20871008 ; 21171011
资助者National Natural Science Foundation of China ; National Natural Science Foundation of China
WOS记录号WOS:000320951600006
引用统计
被引频次:12[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63283
专题北京大学药学院_化学生物学系
作者单位1.Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Dept Biol Chem, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Liu, Jing-Cheng,Yu, You,Wang, Gang,et al. Bis(acetylacetonato)-oxovanadium(IV), bis(maltolato)-oxovanadium(IV) and sodium metavanadate induce antilipolytic effects by regulating hormone-sensitive lipase and perilipin via activation of Akt[J]. METALLOMICS,2013,5(7):813-820.
APA Liu, Jing-Cheng,Yu, You,Wang, Gang,Wang, Kui,&Yang, Xiao-Gai.(2013).Bis(acetylacetonato)-oxovanadium(IV), bis(maltolato)-oxovanadium(IV) and sodium metavanadate induce antilipolytic effects by regulating hormone-sensitive lipase and perilipin via activation of Akt.METALLOMICS,5(7),813-820.
MLA Liu, Jing-Cheng,et al."Bis(acetylacetonato)-oxovanadium(IV), bis(maltolato)-oxovanadium(IV) and sodium metavanadate induce antilipolytic effects by regulating hormone-sensitive lipase and perilipin via activation of Akt".METALLOMICS 5.7(2013):813-820.
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