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Positive association of the oxytocin receptor gene (OXTR) with autism in the Chinese Han population
Wu, SP; Jia, MX; Ruan, Y; Liu, J; Guo, YQ; Shuang, M; Gong, XH; Zhang, YB; Yang, XL; Zhang, D
关键词autism OXTR single nucleotide polymorphism family-based association test hapoltype linkage disequilibrium
刊名BIOLOGICAL PSYCHIATRY
2005-07-01
DOI10.1016/j.biopsych.2005.03.013
58期:1页:74-77
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences ; Psychiatry
研究领域[WOS]Neurosciences & Neurology ; Psychiatry
关键词[WOS]SOCIAL-BEHAVIOR ; TRANSIENT EXPRESSION ; ANIMAL-MODELS ; RAT-BRAIN ; VASOPRESSIN ; NEUROPEPTIDES ; ORGANIZATION ; APPEARANCE ; DISORDERS ; INFANT
英文摘要

Background: Previous research has suggested that the social impairments exhibited by individuals with autism are associated with changes in plasme oxytocin (OT) levels. The physiologic effects of oxytocin are mediated through its specific receptors (OTRs), and numerous studies have implicated OTRs in the regulation of social cognition and behavior, Animal models and linkage data from genome screens indicate that the oxytocin receptor gene (OXTR) is an excellent candidate for research concerning psychiatric disorders, particularly those involving social impairments, such as autism,

Methods: We genotyped four single nucleotide polymorpbisms (SNTs) located within the OXTR gene of 195 Chinese Han autism trios, using polymerase chain reaction-restriction fragment length polymorphism analysis.

Results: The family-based association test (FBAT) revealed a significant genetic association between autism and two of the SNPs tested (rs2254298 A: Z = 2.287 p =.0222, rs53576A: Z = 2,573, p =.0101). When haplotypes were constructed with two, three, and four markers, the haplotype-specific FBAT revealed that a number of haplotypes, particularly those involving rs53576, were significantly associated with autism. Furthermore, haplotypes constructed with all markers showed a significant excess transmission for the specific and global haplotype analyses (p =.0020 and.0289, respectively).

Conclusions: These data suggest an involvement of OXTR in the susceptibility to autism, and replication is important.

语种英语
WOS记录号WOS:000230260100011
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被引频次:330[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63288
专题北京大学精神卫生研究所
作者单位Peking Univ, Inst Mental Hlth, Beijing 100083, Peoples R China
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GB/T 7714
Wu, SP,Jia, MX,Ruan, Y,et al. Positive association of the oxytocin receptor gene (OXTR) with autism in the Chinese Han population[J]. BIOLOGICAL PSYCHIATRY,2005,58(1):74-77.
APA Wu, SP.,Jia, MX.,Ruan, Y.,Liu, J.,Guo, YQ.,...&Zhang, D.(2005).Positive association of the oxytocin receptor gene (OXTR) with autism in the Chinese Han population.BIOLOGICAL PSYCHIATRY,58(1),74-77.
MLA Wu, SP,et al."Positive association of the oxytocin receptor gene (OXTR) with autism in the Chinese Han population".BIOLOGICAL PSYCHIATRY 58.1(2005):74-77.
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