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学科主题: 临床医学
题名:
The relationship between plasma apolipoprotein A-IV levels and coronary heart disease
作者: Warner, MM; Guo, JX; Zhao, YM
关键词: apolipoprotein A-IV ; atherosclerosis ; lipoprotein ; coronary heart disease
刊名: CHINESE MEDICAL JOURNAL
发表日期: 2001-03-01
卷: 114, 期:3, 页:275-279
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: HIGH-DENSITY LIPOPROTEINS ; RAT ; EXPRESSION ; LYMPH ; CELLS
英文摘要:

Objective To evaluate the relationship between plasma apoA-IV levels and coronary atherosclerosis and to explore its relation to other risk factors.

Methods Using ELISA techniques, plasma apoA-IV levels were quantified in 181 patients who underwent coronary angiography (CAG). Patients were divided according to their coronary status into a coronary heart disease (CHD) group (stenotic lesion on GAG, n = 118) and a control group (normal GAG, n = 63). The severity of atherosclerosis was assessed by stenosis scoring of the different lesions. Other parameters, including apoA-I, apoB, Lp(a), HDL-C, LDL-C, TG, and TC, were measured as well. Univariate, logistic regression analyses were used to define the relationship between coronary atherosclerosis and plasma apoA-IV levels.

Results When compared with the control group, plasma apoA-IV levels were found to be lower in the CHD group. There was a weak negative correlation between plasma apoA-IV levels and the severity of coronary atherosclerosis. ApoA-IV was found to be a relatively independent risk factor for CHD. We also found a positive correlation between apoA-IV and triglyceride levels.

Conclusions ApoA-IV may be important in the prediction of CHD and coronary atherosclerosis severity. It may also play an important role in the metabolism of triglycerides.

语种: 英语
WOS记录号: WOS:000167547000011
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63290
Appears in Collections:北京大学第三临床医学院_期刊论文

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作者单位: Beijing Univ, Sch Med, Hosp 3, Beijing 100083, Peoples R China

Recommended Citation:
Warner, MM,Guo, JX,Zhao, YM. The relationship between plasma apolipoprotein A-IV levels and coronary heart disease[J]. CHINESE MEDICAL JOURNAL,2001,114(3):275-279.
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