|The relationship between plasma apolipoprotein A-IV levels and coronary heart disease|
|Warner, MM; Guo, JX; Zhao, YM|
|关键词||apolipoprotein A-IV atherosclerosis lipoprotein coronary heart disease|
|刊名||CHINESE MEDICAL JOURNAL|
|WOS标题词||Science & Technology|
|类目[WOS]||Medicine, General & Internal|
|研究领域[WOS]||General & Internal Medicine|
|关键词[WOS]||HIGH-DENSITY LIPOPROTEINS ; RAT ; EXPRESSION ; LYMPH ; CELLS|
Objective To evaluate the relationship between plasma apoA-IV levels and coronary atherosclerosis and to explore its relation to other risk factors.
Methods Using ELISA techniques, plasma apoA-IV levels were quantified in 181 patients who underwent coronary angiography (CAG). Patients were divided according to their coronary status into a coronary heart disease (CHD) group (stenotic lesion on GAG, n = 118) and a control group (normal GAG, n = 63). The severity of atherosclerosis was assessed by stenosis scoring of the different lesions. Other parameters, including apoA-I, apoB, Lp(a), HDL-C, LDL-C, TG, and TC, were measured as well. Univariate, logistic regression analyses were used to define the relationship between coronary atherosclerosis and plasma apoA-IV levels.
Results When compared with the control group, plasma apoA-IV levels were found to be lower in the CHD group. There was a weak negative correlation between plasma apoA-IV levels and the severity of coronary atherosclerosis. ApoA-IV was found to be a relatively independent risk factor for CHD. We also found a positive correlation between apoA-IV and triglyceride levels.
Conclusions ApoA-IV may be important in the prediction of CHD and coronary atherosclerosis severity. It may also play an important role in the metabolism of triglycerides.
|作者单位||Beijing Univ, Sch Med, Hosp 3, Beijing 100083, Peoples R China|
|Warner, MM,Guo, JX,Zhao, YM. The relationship between plasma apolipoprotein A-IV levels and coronary heart disease[J]. CHINESE MEDICAL JOURNAL,2001,114(3):275-279.|
|APA||Warner, MM,Guo, JX,&Zhao, YM.(2001).The relationship between plasma apolipoprotein A-IV levels and coronary heart disease.CHINESE MEDICAL JOURNAL,114(3),275-279.|
|MLA||Warner, MM,et al."The relationship between plasma apolipoprotein A-IV levels and coronary heart disease".CHINESE MEDICAL JOURNAL 114.3(2001):275-279.|