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学科主题: 临床医学
题名:
p16(INK4a) and laminin-5 gamma 2 chain expression during the progression of cervical neoplasia
作者: Wang, Jian-Liu; Andersson, Sonia; Li, Xidan; Hellstrom, Ann-Cathrin; Auer, Gert; Angstrom, Tord; Lindstrom, Mikael S.; Wallin, Keng-Ling
刊名: ACTA ONCOLOGICA
发表日期: 2006-09-01
DOI: 10.1080/02841860600617092
卷: 45, 期:6, 页:676-684
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: HUMAN-PAPILLOMAVIRUS INFECTION ; SQUAMOUS-CELL CARCINOMA ; GAMMA-2 CHAIN ; P16 PROTEIN ; INTRAEPITHELIAL NEOPLASIA ; DIFFERENTIAL EXPRESSION ; EPITHELIAL-CELLS ; UTERINE CERVIX ; IN-VIVO ; CANCER
英文摘要:

p16(INK4a), laminin-5 gamma 2 chain, and PCNA were investigated to compare the expression levels in relation to histological diagnosis and time for progression. The material consisted of 37 normal cervical tissues, 35 with different grades of CIN, and 11 invasive cervical cancers. Our results showed a reduction of basement membrane staining for laminin-5g2 chain from 78.4% in normal squamous epithelium to 27.8% in CIN3 (p < 0.001). The intracytoplasmic staining for laminin-5 gamma 2 chain increases with severity of lesion. The same trend was observed with p16(INK4a) and PCNA expression (pB < 0.001). Coexpression of p16(INK4a) and PCNA was seen in 85.7% of samples. Cases that were laminin-5 gamma 2 chain BM -p16(INK4a) +/ PCNA+ have the shortest interval time (average: 46.89 +/- 36.3 months) for progression, while cases with laminin-5 gamma 2 chain BM + p16(INK4a) - PCNAPCNA - have the longest time interval ( average: 110.29 +/- 52.7 months) (p < 0.05). Thus co-expression of p16(INK4a), laminin-5 gamma 2 chain and PCNA may be valuable for the prediction progression of cervical neoplasia.

语种: 英语
WOS记录号: WOS:000240078300004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63297
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.Karolinska Univ Hosp, Karolinska Inst, Inst Clin Sci Intervent & Tech, Div Obstet & Gynaecol, S-14186 Huddinge, Sweden
2.Karolinska Univ Hosp, Dept Mol Med & Surg, Karolinska Inst, Ctr Mol Med, S-17176 Stockholm, Sweden
3.Karolinska Univ Hosp, Karolinska Inst, Dept Gynecol Oncol, Radiumhemmet, S-17176 Stockholm, Sweden
4.Karolinska Univ Hosp, Karolinska Inst, Canc Ctr Karolinska, S-17176 Stockholm, Sweden
5.Umea Univ Hosp, Cytol Lab, S-90185 Umea, Sweden
6.Peking Univ, Peoples Hosp, Dept Obstet & Gynecol, Beijing, Peoples R China

Recommended Citation:
Wang, Jian-Liu,Andersson, Sonia,Li, Xidan,et al. p16(INK4a) and laminin-5 gamma 2 chain expression during the progression of cervical neoplasia[J]. ACTA ONCOLOGICA,2006,45(6):676-684.
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