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学科主题临床医学
p16(INK4a) and laminin-5 gamma 2 chain expression during the progression of cervical neoplasia
Wang, Jian-Liu; Andersson, Sonia; Li, Xidan; Hellstrom, Ann-Cathrin; Auer, Gert; Angstrom, Tord; Lindstrom, Mikael S.; Wallin, Keng-Ling
刊名ACTA ONCOLOGICA
2006-09-01
DOI10.1080/02841860600617092
45期:6页:676-684
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]HUMAN-PAPILLOMAVIRUS INFECTION ; SQUAMOUS-CELL CARCINOMA ; GAMMA-2 CHAIN ; P16 PROTEIN ; INTRAEPITHELIAL NEOPLASIA ; DIFFERENTIAL EXPRESSION ; EPITHELIAL-CELLS ; UTERINE CERVIX ; IN-VIVO ; CANCER
英文摘要

p16(INK4a), laminin-5 gamma 2 chain, and PCNA were investigated to compare the expression levels in relation to histological diagnosis and time for progression. The material consisted of 37 normal cervical tissues, 35 with different grades of CIN, and 11 invasive cervical cancers. Our results showed a reduction of basement membrane staining for laminin-5g2 chain from 78.4% in normal squamous epithelium to 27.8% in CIN3 (p < 0.001). The intracytoplasmic staining for laminin-5 gamma 2 chain increases with severity of lesion. The same trend was observed with p16(INK4a) and PCNA expression (pB < 0.001). Coexpression of p16(INK4a) and PCNA was seen in 85.7% of samples. Cases that were laminin-5 gamma 2 chain BM -p16(INK4a) +/ PCNA+ have the shortest interval time (average: 46.89 +/- 36.3 months) for progression, while cases with laminin-5 gamma 2 chain BM + p16(INK4a) - PCNAPCNA - have the longest time interval ( average: 110.29 +/- 52.7 months) (p < 0.05). Thus co-expression of p16(INK4a), laminin-5 gamma 2 chain and PCNA may be valuable for the prediction progression of cervical neoplasia.

语种英语
WOS记录号WOS:000240078300004
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63297
专题北京大学第二临床医学院
作者单位1.Karolinska Univ Hosp, Karolinska Inst, Inst Clin Sci Intervent & Tech, Div Obstet & Gynaecol, S-14186 Huddinge, Sweden
2.Karolinska Univ Hosp, Dept Mol Med & Surg, Karolinska Inst, Ctr Mol Med, S-17176 Stockholm, Sweden
3.Karolinska Univ Hosp, Karolinska Inst, Dept Gynecol Oncol, Radiumhemmet, S-17176 Stockholm, Sweden
4.Karolinska Univ Hosp, Karolinska Inst, Canc Ctr Karolinska, S-17176 Stockholm, Sweden
5.Umea Univ Hosp, Cytol Lab, S-90185 Umea, Sweden
6.Peking Univ, Peoples Hosp, Dept Obstet & Gynecol, Beijing, Peoples R China
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GB/T 7714
Wang, Jian-Liu,Andersson, Sonia,Li, Xidan,et al. p16(INK4a) and laminin-5 gamma 2 chain expression during the progression of cervical neoplasia[J]. ACTA ONCOLOGICA,2006,45(6):676-684.
APA Wang, Jian-Liu.,Andersson, Sonia.,Li, Xidan.,Hellstrom, Ann-Cathrin.,Auer, Gert.,...&Wallin, Keng-Ling.(2006).p16(INK4a) and laminin-5 gamma 2 chain expression during the progression of cervical neoplasia.ACTA ONCOLOGICA,45(6),676-684.
MLA Wang, Jian-Liu,et al."p16(INK4a) and laminin-5 gamma 2 chain expression during the progression of cervical neoplasia".ACTA ONCOLOGICA 45.6(2006):676-684.
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