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Significance of CD71 expression by flow cytometry in diagnosis of acute leukemia
Liu, Qian1; Wang, Mangju1; Hu, Yang1,2; Xing, Haizhou1,2; Chen, Xue1,2; Zhang, Ying1; Zhu, Ping1
关键词CD71 (transferrin receptor 1, TfR-1) acute leukemia flow cytometry clonal evolution
刊名LEUKEMIA & LYMPHOMA
2014-04-01
DOI10.3109/10428194.2013.819100
55期:4页:892-898
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology ; Hematology
研究领域[WOS]Oncology ; Hematology
关键词[WOS]ACUTE NONLYMPHOCYTIC LEUKEMIA ; ACUTE LYMPHOBLASTIC-LEUKEMIA ; ACUTE MYELOID-LEUKEMIA ; RECEPTOR 1 CD71 ; TRANSFERRIN RECEPTOR ; BONE-MARROW ; IMMUNOPHENOTYPIC ANALYSIS ; MYELODYSPLASTIC SYNDROME ; ERYTHROID PRECURSORS ; CELL-PROLIFERATION
英文摘要

In this study we investigated the significance of CD71 (transferrin receptor 1, TfR-1) as a flow cytometric marker in the diagnosis of acute leukemia (AL). A total of 105 patients with AL were enrolled. Poorly differentiated acute myeloid leukemias (AMLs) (including minimally differentiated AML, AML without maturation, AML with maturation, acute myelomonocytic leukemia) tended to express high levels of CD71 on leukemic cells, while partially differentiated AML (including acute promyelocytic leukemia and acute monocytic leukemia) often expressed low levels of CD71 on leukemic cells (p < 0.05, compared to poorly differentiated AML). B-cell acute lymphoblastic leukemia (B-ALL) expressed low levels of CD71 on leukemic cells, significantly lower than AML, mixed phenotype acute leukemia (MPAL) and normal bone marrow blasts (p < 0.05). In the seven cases of acute erythroid leukemia (AEL), leukemic cells rarely expressed CD71, with the mean CD71 expression level significantly lower than that of acute megakaryocytic leukemia (p < 0.05), and also lower than that of poorly differentiated AML and normal blasts but without statistical significance. CD71 may not be a specific marker for AEL leukemic cells. During the process from myeloid dysplasia to apparent leukemic cells, both CD71 and CD34 gradually increased. Consequently, the presence of leukemic cell subsets with variable levels of CD71 and CD34 may be useful for understanding the dynamic processes involved in the clonal development seen in leukemias.

语种英语
WOS记录号WOS:000333582600026
项目编号2008AA02503 ; 81102211
资助机构National 863 High-Tech Research and Development Program of China ; Youth Fund Project of the National Natural Science Foundation of China
引用统计
被引频次:13[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63298
专题北京大学第一临床医学院_血液内科
作者单位1.Beijing Aerosp Gen Hosp, Inst Hematol & Oncol, Beijing, Peoples R China
2.Peking Univ, Dept Hematol, Hosp 1, Beijing 100034, Peoples R China
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GB/T 7714
Liu, Qian,Wang, Mangju,Hu, Yang,et al. Significance of CD71 expression by flow cytometry in diagnosis of acute leukemia[J]. LEUKEMIA &amp; LYMPHOMA,2014,55(4):892-898.
APA Liu, Qian.,Wang, Mangju.,Hu, Yang.,Xing, Haizhou.,Chen, Xue.,...&Zhu, Ping.(2014).Significance of CD71 expression by flow cytometry in diagnosis of acute leukemia.LEUKEMIA & LYMPHOMA,55(4),892-898.
MLA Liu, Qian,et al."Significance of CD71 expression by flow cytometry in diagnosis of acute leukemia".LEUKEMIA & LYMPHOMA 55.4(2014):892-898.
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