IR@PKUHSC  > 北京大学第一临床医学院  > 核医学科
学科主题临床医学
Biodistribution and imaging of Tc-99m-MAVGG-adenine in tumor bearing mice
Zhang, C. L.; Zhao, Y. L.; Feng, S. J.; Qi, C. M.; Fu, Z. L.; Guo, F. G.; Wang, R. F.
刊名JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
2007-07-01
DOI10.1007/s10967-007-0705-0
273期:1页:25-29
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Analytical ; Chemistry, Inorganic & Nuclear ; Nuclear Science & Technology
研究领域[WOS]Chemistry ; Nuclear Science & Technology
关键词[WOS]PRECLINICAL EVALUATION ; PROLIFERATION ; ANALOG ; PET ; RADIOPHARMACEUTICALS ; PHARMACOKINETICS ; CONJUGATION ; OCTREOTIDE ; F-18-FLT ; TC-99M
英文摘要

To increase the tumor uptake of Val-Gly-Gly (VGG), adenine was introduced into the peptide. N-mercaptoacetyl-VGG-adenine (MAVGG-adenine) and MAVGG were labeled with Tc-99m using a solution of SnCl2 and tartaric acid as reducing agent. Biodistribution in mice bearing the S180 tumor was measured and gamma imaging was performed. Compared with MAVGG, adenine conjugated MAVGG had higher tumor uptake and tumor to normal tissue ratios, which suggested that the tumor uptake property of a peptide may be improved by introducing a nucleotide base. The high contrasted tumor images of Tc-99m-MAVGG-adenine also suggested its potential utility as tumor imaging agent.

语种英语
WOS记录号WOS:000247427400005
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63300
专题北京大学第一临床医学院_核医学科
作者单位1.Peking Univ, Hosp 1, Dept Nucl Med, Beijing 100034, Peoples R China
2.Beijing Normal Univ, Dept Chem, Beijing 100875, Peoples R China
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Zhang, C. L.,Zhao, Y. L.,Feng, S. J.,et al. Biodistribution and imaging of Tc-99m-MAVGG-adenine in tumor bearing mice[J]. JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY,2007,273(1):25-29.
APA Zhang, C. L..,Zhao, Y. L..,Feng, S. J..,Qi, C. M..,Fu, Z. L..,...&Wang, R. F..(2007).Biodistribution and imaging of Tc-99m-MAVGG-adenine in tumor bearing mice.JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY,273(1),25-29.
MLA Zhang, C. L.,et al."Biodistribution and imaging of Tc-99m-MAVGG-adenine in tumor bearing mice".JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY 273.1(2007):25-29.
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