IR@PKUHSC  > 北京大学第三临床医学院  > 心血管内科
学科主题临床医学
Dietary Glycemic Index, Glycemic Load, and Risk of Coronary Heart Disease, Stroke, and Stroke Mortality: A Systematic Review with Meta-Analysis
Fan, Jingyao1,2; Song, Yiqing3,4; Wang, Yuyao1,2; Hui, Rutai1,2; Zhang, Weili1,2
刊名PLOS ONE
2012-12-20
DOI10.1371/journal.pone.0052182
7期:12
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]DENSITY-LIPOPROTEIN CHOLESTEROL ; OBESE YOUNG-ADULTS ; MIDDLE-AGED WOMEN ; CARDIOVASCULAR-DISEASE ; CARBOHYDRATE INTAKE ; MYOCARDIAL-INFARCTION ; LIPID PROFILE ; SWEDISH MEN ; OVERWEIGHT ; AMERICANS
英文摘要

Background: The relationship between dietary glycemic index, glycemic load and risk of coronary heart disease (CHD), stroke, and stroke-related mortality is inconsistent.

Methods: We systematically searched the MEDLINE, EMBASE, and Science Citation Index Expanded databases using glycemic index, glycemic load, and cardiovascular disease and reference lists of retrieved articles up to April 30, 2012. We included prospective studies with glycemic index and glycemic load as the exposure and incidence of fatal and nonfatal CHD, stroke, and stroke-related mortality as the outcome variable. Pooled relative risks (RR) and 95% confidence intervals (CI) were calculated using random-effects models.

Results: Fifteen prospective studies with a total of 438,073 participants and 9,424 CHD cases, 2,123 stroke cases, and 342 deaths from stroke were included in the meta-analysis. Gender significantly modified the effects of glycemic index and glycemic load on CHD risk, and high glycemic load level was associated with higher risk of CHD in women (RR = 1.49, 95% CI 1.27-1.73), but not in men (RR = 1.08, 95% CI 0.91-1.27). Stratified meta-analysis by body mass index indicated that among overweight and obese subjects, dietary glycemic load level were associated with increased risk of CHD (RR = 1.49, 95% CI 1.27-1.76; P for interaction = 0.003). Higher dietary glycemic load, but not glycemic index, was positively associated with stroke (RR = 1.19, 95% CI 1.00-1.43). There is a linear dose-response relationship between dietary glycemic load and increased risk of CHD, with pooled RR of 1.05 (95% CI 1.02-1.08) per 50-unit increment in glycemic load level.

Conclusion: High dietary glycemic load is associated with a higher risk of CHD and stroke, and there is a linear dose-response relationship between glycemic load and CHD risk. Dietary glycemic index is slightly associated with risk of CHD, but not with stroke and stroke-related death. Further studies are needed to verify the effects of gender and body weight on cardiovascular diseases.

语种英语
WOS记录号WOS:000312794500107
项目编号2011CB503901 ; 81070172
资助机构Ministry of Science and Technology of China ; National Natural Science of China
引用统计
被引频次:59[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63303
专题北京大学第三临床医学院_心血管内科
作者单位1.Peking Union Med Coll, Sino German Lab Mol Med, State Key Lab Cardiovasc Dis, FuWai Hosp,Natl Ctr Cardiovasc Dis, Beijing 100021, Peoples R China
2.Chinese Acad Med Sci, Beijing 100730, Peoples R China
3.Peking Univ, Inst Vasc Med, Hosp 3, Minist Hlth, Beijing 100871, Peoples R China
4.Harvard Univ, Brigham & Womens Hosp, Dept Med, Div Prevent Med,Med Sch, Boston, MA 02115 USA
推荐引用方式
GB/T 7714
Fan, Jingyao,Song, Yiqing,Wang, Yuyao,et al. Dietary Glycemic Index, Glycemic Load, and Risk of Coronary Heart Disease, Stroke, and Stroke Mortality: A Systematic Review with Meta-Analysis[J]. PLOS ONE,2012,7(12).
APA Fan, Jingyao,Song, Yiqing,Wang, Yuyao,Hui, Rutai,&Zhang, Weili.(2012).Dietary Glycemic Index, Glycemic Load, and Risk of Coronary Heart Disease, Stroke, and Stroke Mortality: A Systematic Review with Meta-Analysis.PLOS ONE,7(12).
MLA Fan, Jingyao,et al."Dietary Glycemic Index, Glycemic Load, and Risk of Coronary Heart Disease, Stroke, and Stroke Mortality: A Systematic Review with Meta-Analysis".PLOS ONE 7.12(2012).
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Fan, Jingyao]的文章
[Song, Yiqing]的文章
[Wang, Yuyao]的文章
百度学术
百度学术中相似的文章
[Fan, Jingyao]的文章
[Song, Yiqing]的文章
[Wang, Yuyao]的文章
必应学术
必应学术中相似的文章
[Fan, Jingyao]的文章
[Song, Yiqing]的文章
[Wang, Yuyao]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。