|Dietary Glycemic Index, Glycemic Load, and Risk of Coronary Heart Disease, Stroke, and Stroke Mortality: A Systematic Review with Meta-Analysis|
|Fan, Jingyao1,2; Song, Yiqing3,4; Wang, Yuyao1,2; Hui, Rutai1,2; Zhang, Weili1,2|
|WOS标题词||Science & Technology|
|研究领域[WOS]||Science & Technology - Other Topics|
|关键词[WOS]||DENSITY-LIPOPROTEIN CHOLESTEROL ; OBESE YOUNG-ADULTS ; MIDDLE-AGED WOMEN ; CARDIOVASCULAR-DISEASE ; CARBOHYDRATE INTAKE ; MYOCARDIAL-INFARCTION ; LIPID PROFILE ; SWEDISH MEN ; OVERWEIGHT ; AMERICANS|
Background: The relationship between dietary glycemic index, glycemic load and risk of coronary heart disease (CHD), stroke, and stroke-related mortality is inconsistent.
Methods: We systematically searched the MEDLINE, EMBASE, and Science Citation Index Expanded databases using glycemic index, glycemic load, and cardiovascular disease and reference lists of retrieved articles up to April 30, 2012. We included prospective studies with glycemic index and glycemic load as the exposure and incidence of fatal and nonfatal CHD, stroke, and stroke-related mortality as the outcome variable. Pooled relative risks (RR) and 95% confidence intervals (CI) were calculated using random-effects models.
Results: Fifteen prospective studies with a total of 438,073 participants and 9,424 CHD cases, 2,123 stroke cases, and 342 deaths from stroke were included in the meta-analysis. Gender significantly modified the effects of glycemic index and glycemic load on CHD risk, and high glycemic load level was associated with higher risk of CHD in women (RR = 1.49, 95% CI 1.27-1.73), but not in men (RR = 1.08, 95% CI 0.91-1.27). Stratified meta-analysis by body mass index indicated that among overweight and obese subjects, dietary glycemic load level were associated with increased risk of CHD (RR = 1.49, 95% CI 1.27-1.76; P for interaction = 0.003). Higher dietary glycemic load, but not glycemic index, was positively associated with stroke (RR = 1.19, 95% CI 1.00-1.43). There is a linear dose-response relationship between dietary glycemic load and increased risk of CHD, with pooled RR of 1.05 (95% CI 1.02-1.08) per 50-unit increment in glycemic load level.
Conclusion: High dietary glycemic load is associated with a higher risk of CHD and stroke, and there is a linear dose-response relationship between glycemic load and CHD risk. Dietary glycemic index is slightly associated with risk of CHD, but not with stroke and stroke-related death. Further studies are needed to verify the effects of gender and body weight on cardiovascular diseases.
|项目编号||2011CB503901 ; 81070172|
|资助机构||Ministry of Science and Technology of China ; National Natural Science of China|
|作者单位||1.Peking Union Med Coll, Sino German Lab Mol Med, State Key Lab Cardiovasc Dis, FuWai Hosp,Natl Ctr Cardiovasc Dis, Beijing 100021, Peoples R China|
2.Chinese Acad Med Sci, Beijing 100730, Peoples R China
3.Peking Univ, Inst Vasc Med, Hosp 3, Minist Hlth, Beijing 100871, Peoples R China
4.Harvard Univ, Brigham & Womens Hosp, Dept Med, Div Prevent Med,Med Sch, Boston, MA 02115 USA
|Fan, Jingyao,Song, Yiqing,Wang, Yuyao,et al. Dietary Glycemic Index, Glycemic Load, and Risk of Coronary Heart Disease, Stroke, and Stroke Mortality: A Systematic Review with Meta-Analysis[J]. PLOS ONE,2012,7(12).|
|APA||Fan, Jingyao,Song, Yiqing,Wang, Yuyao,Hui, Rutai,&Zhang, Weili.(2012).Dietary Glycemic Index, Glycemic Load, and Risk of Coronary Heart Disease, Stroke, and Stroke Mortality: A Systematic Review with Meta-Analysis.PLOS ONE,7(12).|
|MLA||Fan, Jingyao,et al."Dietary Glycemic Index, Glycemic Load, and Risk of Coronary Heart Disease, Stroke, and Stroke Mortality: A Systematic Review with Meta-Analysis".PLOS ONE 7.12(2012).|