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学科主题: 临床医学
题名:
The PPAR gamma agonist Troglitazone induces autophagy, apoptosis and necroptosis in bladder cancer cells
作者: Yan, S.1,2; Yang, X.3; Chen, T.1,4; Xi, Z.3; Jiang, X.1
刊名: CANCER GENE THERAPY
发表日期: 2014-05-01
DOI: 10.1038/cgt.2014.16
卷: 21, 期:5, 页:188-193
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biotechnology & Applied Microbiology ; Oncology ; Genetics & Heredity ; Medicine, Research & Experimental
研究领域[WOS]: Biotechnology & Applied Microbiology ; Oncology ; Genetics & Heredity ; Research & Experimental Medicine
关键词[WOS]: ACTIVATED PROTEIN-KINASE ; UROTHELIAL CELLS ; DEATH ; ULK1 ; AMPK ; INFLAMMATION ; DEGRADATION ; INHIBITION ; CARCINOMA ; GROWTH
英文摘要:

Bladder cancer is a major public health problem worldwide, with relatively high morbidity. However, there are few studies on drug development for bladder cancer. Troglitazone (TZ) is a synthetic ligand of peroxisome proliferator-activated receptor-gamma, and it can induce apoptosis and autophagy in a variety of cancer cells. Several studies have indicated that TZ affects both cell growth and differentiation progress and has an inhibitory effect on urinary cancer cells. However, this drug′s effect on bladder cancer cells remains largely unknown. Here, we report that TZ induced autophagy and enhanced apoptosis in T24 cells. Autophagic blockage resulted in the attenuation of TZ-dependent apoptosis. Necrostatin-1, an inhibitor of necroptosis, was found to reduce light chain 3 (LC3)-II accumulation and partially rescue the loss of cell viability induced by TZ. It was demonstrated that TZ activated autophagy concurrent with the activation of the adenosine monophosphate-dependent protein kinase (AMPK) signaling pathway. AMPK inhibition led to a reduction in LC3-II levels, which were responsive to TZ treatment. Overall, TZ induced multiple types of programmed cell death in bladder cancer cells, and while the autophagy induced by the agonist contributed to the apoptotic process, crosstalk or switching between the different types of cell death likely occurred.

语种: 英语
所属项目编号: 31171329 ; 81272829
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000336776800003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63310
Appears in Collections:北京大学第一临床医学院_泌尿外科_期刊论文

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作者单位: 1.Chinese Acad Sci, Inst Microbiol, State Key Lab Mycol, Beijing, Peoples R China
2.Univ Chinese Acad Sci, Coll Life Sci, Beijing, Peoples R China
3.Peking Univ, Hosp 1, Inst Urol, Dept Urol, Beijing 100034, Peoples R China
4.Liaoning Univ, Sch Life Sci, Shenyang 110036, Peoples R China

Recommended Citation:
Yan, S.,Yang, X.,Chen, T.,et al. The PPAR gamma agonist Troglitazone induces autophagy, apoptosis and necroptosis in bladder cancer cells[J]. CANCER GENE THERAPY,2014,21(5):188-193.
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