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学科主题临床医学
The PPAR gamma agonist Troglitazone induces autophagy, apoptosis and necroptosis in bladder cancer cells
Yan, S.1,2; Yang, X.3; Chen, T.1,4; Xi, Z.3; Jiang, X.1
刊名CANCER GENE THERAPY
2014-05-01
DOI10.1038/cgt.2014.16
21期:5页:188-193
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biotechnology & Applied Microbiology ; Oncology ; Genetics & Heredity ; Medicine, Research & Experimental
研究领域[WOS]Biotechnology & Applied Microbiology ; Oncology ; Genetics & Heredity ; Research & Experimental Medicine
关键词[WOS]ACTIVATED PROTEIN-KINASE ; UROTHELIAL CELLS ; DEATH ; ULK1 ; AMPK ; INFLAMMATION ; DEGRADATION ; INHIBITION ; CARCINOMA ; GROWTH
英文摘要

Bladder cancer is a major public health problem worldwide, with relatively high morbidity. However, there are few studies on drug development for bladder cancer. Troglitazone (TZ) is a synthetic ligand of peroxisome proliferator-activated receptor-gamma, and it can induce apoptosis and autophagy in a variety of cancer cells. Several studies have indicated that TZ affects both cell growth and differentiation progress and has an inhibitory effect on urinary cancer cells. However, this drug′s effect on bladder cancer cells remains largely unknown. Here, we report that TZ induced autophagy and enhanced apoptosis in T24 cells. Autophagic blockage resulted in the attenuation of TZ-dependent apoptosis. Necrostatin-1, an inhibitor of necroptosis, was found to reduce light chain 3 (LC3)-II accumulation and partially rescue the loss of cell viability induced by TZ. It was demonstrated that TZ activated autophagy concurrent with the activation of the adenosine monophosphate-dependent protein kinase (AMPK) signaling pathway. AMPK inhibition led to a reduction in LC3-II levels, which were responsive to TZ treatment. Overall, TZ induced multiple types of programmed cell death in bladder cancer cells, and while the autophagy induced by the agonist contributed to the apoptotic process, crosstalk or switching between the different types of cell death likely occurred.

语种英语
WOS记录号WOS:000336776800003
项目编号31171329 ; 81272829
资助机构National Natural Science Foundation of China
引用统计
被引频次:24[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63310
专题北京大学第一临床医学院_泌尿外科
作者单位1.Chinese Acad Sci, Inst Microbiol, State Key Lab Mycol, Beijing, Peoples R China
2.Univ Chinese Acad Sci, Coll Life Sci, Beijing, Peoples R China
3.Peking Univ, Hosp 1, Inst Urol, Dept Urol, Beijing 100034, Peoples R China
4.Liaoning Univ, Sch Life Sci, Shenyang 110036, Peoples R China
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GB/T 7714
Yan, S.,Yang, X.,Chen, T.,et al. The PPAR gamma agonist Troglitazone induces autophagy, apoptosis and necroptosis in bladder cancer cells[J]. CANCER GENE THERAPY,2014,21(5):188-193.
APA Yan, S.,Yang, X.,Chen, T.,Xi, Z.,&Jiang, X..(2014).The PPAR gamma agonist Troglitazone induces autophagy, apoptosis and necroptosis in bladder cancer cells.CANCER GENE THERAPY,21(5),188-193.
MLA Yan, S.,et al."The PPAR gamma agonist Troglitazone induces autophagy, apoptosis and necroptosis in bladder cancer cells".CANCER GENE THERAPY 21.5(2014):188-193.
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