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学科主题: 临床医学
题名:
Elevated plasma lipoprotein-associated phospholipase A(2) activity is associated with plaque rupture in patients with coronary artery disease
作者: Liu Chuan-fen1; Qin Li2; Ren Jing-yi1; Chen Hong1; Wang Wei-min1; Liu Jian1; Song Jun-xian1; Li Li-jun1
关键词: lipoprotein-associated phospholipase A(2) ; plaque ; intravascular ultrasound ; inflammation ; coronary artery disease
刊名: CHINESE MEDICAL JOURNAL
发表日期: 2011-08-20
DOI: 10.3760/cma.j.issn.0366-6999.2011.16.013
卷: 124, 期:16, 页:2469-2473
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: ATHEROSCLEROTIC PLAQUE ; INTRAVASCULAR ULTRASOUND ; CARDIOVASCULAR OUTCOMES ; EVENTS ; PREVENTION ; BRUNECK ; LESIONS
英文摘要:

Background Lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) has recently been shown to be positively related to coronary events in patients with coronary artery disease (CAD). However, direct evidence about the relationship between circulation Lp-PLA(2) activity and vulnerable plaque in patients with CAD remains lacking.

Methods Plasma Lp-PLA(2) activity was determined in 146 consecutive patients with CAD who underwent clinically-indicated coronary angiography and preinterventional intravascular ultrasound (IVUS).

Results Eighty-three patients were included in the final analysis after the initial screening. Sixty (72.3%) were acute coronary syndrome (ACS) patients and 23 (27.7%) were stable angina pectoris (SAP) patients. Plaque rupture occurred in 39 (47.0%) patients, and 34 (87.2%) were from ACS patients and 5 (12.8%) from SAP patients. There were no significant differences in clinical and angiographic characteristics between patients with plaque rupture and those without plaque rupture, except for smoking, high-sensitive C-reactive protein (hs-CRP) level and Lp-PLA(2) activity (all P<0.05). IVUS measurement uncovered that patients with plaque rupture had more frequent positive remodeling (74.4% vs. 43.2%, P=0.004), soft plaques (64.1% vs. 36.4%, P=0.012) and higher remodeling index (1.13 +/- 0.16 vs. 0.99 +/- 0.11, P=0.041) as compared with those without plaque rupture. Multivariate Logistic regression analysis showed that plasma Lp-PLA(2) activity was independently associated with plaque rupture after adjusting for smoking, positive remodeling and soft plaque (Model 1: odds ratio (OR) 1.13, 95% confidence interval (CI) : 1.06-1.20) or adjusting for smoking, hs-CRP level, positive remodeling and soft plaque (Model 2: OR 1.11, 95% CI 1.04-1.19).

Conclusions Plasma Lp-PLA(2) activity is associated with plaque rupture in patients with CAD, independently of traditional CAD risk factors, hs-CRP level and IVUS parameters. Lp-PLA(2) may be a risk marker for vulnerable plaques. Chin Med J 2011;124(16):2469-2473

语种: 英语
所属项目编号: 30570712 ; 30840040 ; 7092109
项目资助者: National Natural Science Foundation of China ; Beijing Natural Science Foundation
WOS记录号: WOS:000294584200013
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63319
Appears in Collections:北京大学第二临床医学院_心血管内科_期刊论文

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作者单位: 1.Peking Univ, Peoples Hosp, Dept Cardiol, Beijing 100044, Peoples R China
2.Peking Univ, Peoples Hosp, Dept Lab Med, Beijing 100044, Peoples R China

Recommended Citation:
Liu Chuan-fen,Qin Li,Ren Jing-yi,et al. Elevated plasma lipoprotein-associated phospholipase A(2) activity is associated with plaque rupture in patients with coronary artery disease[J]. CHINESE MEDICAL JOURNAL,2011,124(16):2469-2473.
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