|Elevated plasma lipoprotein-associated phospholipase A(2) activity is associated with plaque rupture in patients with coronary artery disease|
|Liu Chuan-fen1; Qin Li2; Ren Jing-yi1; Chen Hong1; Wang Wei-min1; Liu Jian1; Song Jun-xian1; Li Li-jun1|
|关键词||lipoprotein-associated phospholipase A(2) plaque intravascular ultrasound inflammation coronary artery disease|
|刊名||CHINESE MEDICAL JOURNAL|
|WOS标题词||Science & Technology|
|类目[WOS]||Medicine, General & Internal|
|研究领域[WOS]||General & Internal Medicine|
|关键词[WOS]||ATHEROSCLEROTIC PLAQUE ; INTRAVASCULAR ULTRASOUND ; CARDIOVASCULAR OUTCOMES ; EVENTS ; PREVENTION ; BRUNECK ; LESIONS|
Background Lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) has recently been shown to be positively related to coronary events in patients with coronary artery disease (CAD). However, direct evidence about the relationship between circulation Lp-PLA(2) activity and vulnerable plaque in patients with CAD remains lacking.
Methods Plasma Lp-PLA(2) activity was determined in 146 consecutive patients with CAD who underwent clinically-indicated coronary angiography and preinterventional intravascular ultrasound (IVUS).
Results Eighty-three patients were included in the final analysis after the initial screening. Sixty (72.3%) were acute coronary syndrome (ACS) patients and 23 (27.7%) were stable angina pectoris (SAP) patients. Plaque rupture occurred in 39 (47.0%) patients, and 34 (87.2%) were from ACS patients and 5 (12.8%) from SAP patients. There were no significant differences in clinical and angiographic characteristics between patients with plaque rupture and those without plaque rupture, except for smoking, high-sensitive C-reactive protein (hs-CRP) level and Lp-PLA(2) activity (all P<0.05). IVUS measurement uncovered that patients with plaque rupture had more frequent positive remodeling (74.4% vs. 43.2%, P=0.004), soft plaques (64.1% vs. 36.4%, P=0.012) and higher remodeling index (1.13 +/- 0.16 vs. 0.99 +/- 0.11, P=0.041) as compared with those without plaque rupture. Multivariate Logistic regression analysis showed that plasma Lp-PLA(2) activity was independently associated with plaque rupture after adjusting for smoking, positive remodeling and soft plaque (Model 1: odds ratio (OR) 1.13, 95% confidence interval (CI) : 1.06-1.20) or adjusting for smoking, hs-CRP level, positive remodeling and soft plaque (Model 2: OR 1.11, 95% CI 1.04-1.19).
Conclusions Plasma Lp-PLA(2) activity is associated with plaque rupture in patients with CAD, independently of traditional CAD risk factors, hs-CRP level and IVUS parameters. Lp-PLA(2) may be a risk marker for vulnerable plaques. Chin Med J 2011;124(16):2469-2473
|项目编号||30570712 ; 30840040 ; 7092109|
|资助机构||National Natural Science Foundation of China ; Beijing Natural Science Foundation|
|作者单位||1.Peking Univ, Peoples Hosp, Dept Cardiol, Beijing 100044, Peoples R China|
2.Peking Univ, Peoples Hosp, Dept Lab Med, Beijing 100044, Peoples R China
|Liu Chuan-fen,Qin Li,Ren Jing-yi,et al. Elevated plasma lipoprotein-associated phospholipase A(2) activity is associated with plaque rupture in patients with coronary artery disease[J]. CHINESE MEDICAL JOURNAL,2011,124(16):2469-2473.|
|APA||Liu Chuan-fen.,Qin Li.,Ren Jing-yi.,Chen Hong.,Wang Wei-min.,...&Li Li-jun.(2011).Elevated plasma lipoprotein-associated phospholipase A(2) activity is associated with plaque rupture in patients with coronary artery disease.CHINESE MEDICAL JOURNAL,124(16),2469-2473.|
|MLA||Liu Chuan-fen,et al."Elevated plasma lipoprotein-associated phospholipase A(2) activity is associated with plaque rupture in patients with coronary artery disease".CHINESE MEDICAL JOURNAL 124.16(2011):2469-2473.|