IR@PKUHSC  > 北京大学第三临床医学院  > 肿瘤放疗科
学科主题临床医学
Interstitial I-125 Seed Implantation for Cervical Lymph Node Recurrence after Multimodal Treatment of Thoracic Esophageal Squamous Cell Carcinoma
Lin, Lei1; Wang, Junjie1; Jiang, Yuliang1; Meng, Na1; Tian, Suqing1; Yang, Ruijie1; Ran, Weiqiang2; Liu, Chen3
关键词Cervical lymph node Esophageal cancer I-125 seed implantation
刊名TECHNOLOGY IN CANCER RESEARCH & TREATMENT
2015-04-01
DOI10.7785/tcrt.2012.500409
14期:2页:201-207
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]RADIATION-THERAPY ; BRACHYTHERAPY SOURCES ; PROGNOSTIC-FACTORS ; CANCER ; LYMPHADENECTOMY ; MICROMETASTASES ; RECOMMENDATIONS ; DOSIMETRY ; PATTERN
英文摘要

This study aimed to analysis outcome and prognosis of interstitial I-125 seed implantation in patients with cervical lymph node recurrence after multimodal treatment of thoracic esophageal squamous cell carcinoma (ESCC). We conducted a retrospective review of 19 patients with 32 cervical lymph nodes recurrences after multimodal treatment (lymphadenectomy, radiotherapy, chemotherapy, and various combinations of these treatments) of thoracic ESCC, who underwent 125I seed implantation in our department from 2003 to 2011. All the patients were followed up until expiration and the median duration of follow up was 7 months (range, 3-44 months). Syndromes significantly improved after implantation. The local control rates after 3, 6, 12, and 24 months were 84.2%, 63.2%, 32.0%, and 26.0%, respectively, with a median of 10 months. The median overall survival time was 7 months (95% CI, 5.6-8.4), and 1- and 2-year survival rates were 31.6% and 10.5%, respectively. Among these patients, there were 11 died of progression of disease (PD) 3-44 months after implantation. One patient presented grade IV skin toxic effect and repaired by free flap transplantation. No fatal complications such as massive bleeding happened. In univariate analysis, N stage, number of recurrent nodes, recurrence interval time, and D90 were prognostic factors of the tumor local control and survival (p = 0.131 vs. 0.029, 0.129 vs. 0.071, 0.042 vs. 0.042, and 0.056 vs. 0.065, respectively). Multivariate analysis demonstrated that N stage, number of recurrent nodes, and recurrence interval time were independent prognostic factors of the tumor local control (p = 0.022, 0.019, and. 0.001, respectively), and recurrence interval time was prognostic factor of the survival (p < 0.001). Interstitial I-125 seed implantation is a safe and effective salvage treatment for cervical lymph node recurrence after multimodal treatment. The N stage, number of recurrent nodes and recurrence interval time are factors influencing tumor local control, and the recurrence interval time is independent factor influencing survival after percutaneous I-125 seed implantation in ESCC with cervical lymph node recurrence.

语种英语
WOS记录号WOS:000354548700006
引用统计
被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63322
专题北京大学第三临床医学院_肿瘤放疗科
作者单位1.Peking Univ, Hosp 3rd, Dept Radiat Oncol, Beijing 100191, Peoples R China
2.Peking Univ, Hosp 3rd, Dept Ultrasonol, Beijing 100191, Peoples R China
3.Peking Univ, Hosp 3rd, Dept Radiol, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Lin, Lei,Wang, Junjie,Jiang, Yuliang,et al. Interstitial I-125 Seed Implantation for Cervical Lymph Node Recurrence after Multimodal Treatment of Thoracic Esophageal Squamous Cell Carcinoma[J]. TECHNOLOGY IN CANCER RESEARCH &amp; TREATMENT,2015,14(2):201-207.
APA Lin, Lei.,Wang, Junjie.,Jiang, Yuliang.,Meng, Na.,Tian, Suqing.,...&Liu, Chen.(2015).Interstitial I-125 Seed Implantation for Cervical Lymph Node Recurrence after Multimodal Treatment of Thoracic Esophageal Squamous Cell Carcinoma.TECHNOLOGY IN CANCER RESEARCH & TREATMENT,14(2),201-207.
MLA Lin, Lei,et al."Interstitial I-125 Seed Implantation for Cervical Lymph Node Recurrence after Multimodal Treatment of Thoracic Esophageal Squamous Cell Carcinoma".TECHNOLOGY IN CANCER RESEARCH & TREATMENT 14.2(2015):201-207.
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