北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第三临床医学院  > 肿瘤放疗科  > 期刊论文
学科主题: 临床医学
题名:
Interstitial I-125 Seed Implantation for Cervical Lymph Node Recurrence after Multimodal Treatment of Thoracic Esophageal Squamous Cell Carcinoma
作者: Lin, Lei1; Wang, Junjie1; Jiang, Yuliang1; Meng, Na1; Tian, Suqing1; Yang, Ruijie1; Ran, Weiqiang2; Liu, Chen3
关键词: Cervical lymph node ; Esophageal cancer ; I-125 seed implantation
刊名: TECHNOLOGY IN CANCER RESEARCH & TREATMENT
发表日期: 2015-04-01
DOI: 10.7785/tcrt.2012.500409
卷: 14, 期:2, 页:201-207
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: RADIATION-THERAPY ; BRACHYTHERAPY SOURCES ; PROGNOSTIC-FACTORS ; CANCER ; LYMPHADENECTOMY ; MICROMETASTASES ; RECOMMENDATIONS ; DOSIMETRY ; PATTERN
英文摘要:

This study aimed to analysis outcome and prognosis of interstitial I-125 seed implantation in patients with cervical lymph node recurrence after multimodal treatment of thoracic esophageal squamous cell carcinoma (ESCC). We conducted a retrospective review of 19 patients with 32 cervical lymph nodes recurrences after multimodal treatment (lymphadenectomy, radiotherapy, chemotherapy, and various combinations of these treatments) of thoracic ESCC, who underwent 125I seed implantation in our department from 2003 to 2011. All the patients were followed up until expiration and the median duration of follow up was 7 months (range, 3-44 months). Syndromes significantly improved after implantation. The local control rates after 3, 6, 12, and 24 months were 84.2%, 63.2%, 32.0%, and 26.0%, respectively, with a median of 10 months. The median overall survival time was 7 months (95% CI, 5.6-8.4), and 1- and 2-year survival rates were 31.6% and 10.5%, respectively. Among these patients, there were 11 died of progression of disease (PD) 3-44 months after implantation. One patient presented grade IV skin toxic effect and repaired by free flap transplantation. No fatal complications such as massive bleeding happened. In univariate analysis, N stage, number of recurrent nodes, recurrence interval time, and D90 were prognostic factors of the tumor local control and survival (p = 0.131 vs. 0.029, 0.129 vs. 0.071, 0.042 vs. 0.042, and 0.056 vs. 0.065, respectively). Multivariate analysis demonstrated that N stage, number of recurrent nodes, and recurrence interval time were independent prognostic factors of the tumor local control (p = 0.022, 0.019, and. 0.001, respectively), and recurrence interval time was prognostic factor of the survival (p < 0.001). Interstitial I-125 seed implantation is a safe and effective salvage treatment for cervical lymph node recurrence after multimodal treatment. The N stage, number of recurrent nodes and recurrence interval time are factors influencing tumor local control, and the recurrence interval time is independent factor influencing survival after percutaneous I-125 seed implantation in ESCC with cervical lymph node recurrence.

语种: 英语
WOS记录号: WOS:000354548700006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63322
Appears in Collections:北京大学第三临床医学院_肿瘤放疗科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, Hosp 3rd, Dept Radiat Oncol, Beijing 100191, Peoples R China
2.Peking Univ, Hosp 3rd, Dept Ultrasonol, Beijing 100191, Peoples R China
3.Peking Univ, Hosp 3rd, Dept Radiol, Beijing 100191, Peoples R China

Recommended Citation:
Lin, Lei,Wang, Junjie,Jiang, Yuliang,et al. Interstitial I-125 Seed Implantation for Cervical Lymph Node Recurrence after Multimodal Treatment of Thoracic Esophageal Squamous Cell Carcinoma[J]. TECHNOLOGY IN CANCER RESEARCH &amp; TREATMENT,2015,14(2):201-207.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Lin, Lei]'s Articles
[Wang, Junjie]'s Articles
[Jiang, Yuliang]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Lin, Lei]‘s Articles
[Wang, Junjie]‘s Articles
[Jiang, Yuliang]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace