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学科主题: 药学
题名:
Intramolecular Larock indole synthesis for the preparation of tricyclic indoles and its application in the synthesis of tetrahydropyrroloquinoline and fargesine
作者: Gao, Yan1; Shan, Dong1; Jia, Yanxing1,2
关键词: Palladium-catalyzed ; Total synthesis ; Natural product ; Indole alkaloids ; Tetrahydropyrroloquinoline
刊名: TETRAHEDRON
发表日期: 2014-08-26
DOI: 10.1016/j.tet.2014.05.108
卷: 70, 期:34, 页:5136-5141
收录类别: SCI ; IC
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Organic
研究领域[WOS]: Chemistry
关键词[WOS]: FORMAL TOTAL-SYNTHESIS ; (+)-LYSERGIC ACID ; NATURAL-PRODUCTS ; BIOMIMETIC SYNTHESIS ; (+/-)-COMMUNESIN F ; CLAVICIPITIC ACID ; INTERNAL ALKYNES ; CYCLIZATION ; ALKALOIDS ; CONSTRUCTION
英文摘要:

A general and efficient strategy for fused tricyclic indoles from substituted 2-halogenanilines via the palladium-catalyzed intramolecular Larock indolization process has been developed. Using this strategy, a number of 3,4- and 3,5-fused indoles with a variety of ring sizes can been prepared. The utility of this method is demonstrated through the synthesis of the known tetrahydropyrrolo[4,3,2-de]quinoline 10 and the first total synthesis of fargesine. (C) 2014 Elsevier Ltd. All rights reserved.

语种: 英语
所属项目编号: 21372017 ; 21290183 ; 2010CB833200
项目资助者: National Natural Science Foundation of China ; National Basic Research Program of China (973 Program)
WOS记录号: WOS:000339035200016
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63323
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China

Recommended Citation:
Gao, Yan,Shan, Dong,Jia, Yanxing. Intramolecular Larock indole synthesis for the preparation of tricyclic indoles and its application in the synthesis of tetrahydropyrroloquinoline and fargesine[J]. TETRAHEDRON,2014,70(34):5136-5141.
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