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IR@PKUHSC  > 北京大学临床肿瘤学院  > 期刊论文
学科主题: 临床医学
题名:
The Changing Face of HDAC Inhibitor Depsipeptide
作者: Zhou, Wen2; Zhu, Wei-Guo1,2
关键词: Histone deacetylase ; HDAC inhibitor ; depsipeptide ; SAHA ; TSA
刊名: CURRENT CANCER DRUG TARGETS
发表日期: 2009-02-01
卷: 9, 期:1, 页:91-100
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: HISTONE-DEACETYLASE INHIBITORS ; CHROMOBACTERIUM-VIOLACEUM NO-968 ; T-CELL LYMPHOMA ; DNA METHYLATION ; POSTTRANSLATIONAL MODIFICATIONS ; TRANSCRIPTIONAL REGULATION ; FUNCTIONAL-ANALYSIS ; PROSTATE-CANCER ; BREAST-CANCER ; C-TERMINUS
英文摘要:

Histone deacetylase (HDAC) inhibitors are currently used in the study of epigenetics and have potential in clinical cancer therapy. A novel and potent HDAC inhibitor, depsipeptide, also known as FK228 or FR901228, is highly efficient in inhibiting the activity of HDACs even at nanomolar concentrations. Depsipeptide has a unique structure that is distinct from most of the other HDACs, and it thus exhibits diverse pharmacologic functions. In addition, depsipeptide has a metabolic activation pathway, which affects many intracellular processes. However, the specific features of this pathway are as yet not completely worked out. In this article, we will focus on the uniqueness of this molecule′s specific structure, the relationship of this structure to its putative metabolic activation pathway, and specifically review its newly discovered biological functions and clinical applications.

语种: 英语
所属项目编号: 2005CB522403 ; 2006AA02Z101 ; 2006CB910300 ; B07001 ; 30670417 ; 30621002
项目资助者: Ministry of Science and Technology of China ; National Natural and Scientific Foundation of China
WOS记录号: WOS:000263286000006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63332
Appears in Collections:北京大学临床肿瘤学院_期刊论文

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作者单位: 1.Peking Univ, Hlth Sci Ctr, Sch Oncol, Beijing 100191, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Biochem & Mol Biol, Beijing 100191, Peoples R China

Recommended Citation:
Zhou, Wen,Zhu, Wei-Guo. The Changing Face of HDAC Inhibitor Depsipeptide[J]. CURRENT CANCER DRUG TARGETS,2009,9(1):91-100.
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