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学科主题口腔医学
FOXO1 differentially regulates both normal and diabetic wound healing
Zhang, Chenying1,2; Ponugoti, Bhaskar2; Tian, Chen2; Xu, Fanxing2,3; Tarapore, Rohinton2; Batres, Angelika2; Alsadun, Sarah2; Lim, Jason2; Dong, Guangyu2; Graves, Dana T.2
刊名JOURNAL OF CELL BIOLOGY
2015-04-27
DOI10.1083/jcb.201409032
209期:2页:289-303
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cell Biology
研究领域[WOS]Cell Biology
关键词[WOS]GLYCATION END-PRODUCTS ; NECROSIS-FACTOR-ALPHA ; GROWTH-FACTOR-BETA ; CELL-MIGRATION ; KERATINOCYTE MIGRATION ; TRANSCRIPTION FACTORS ; DEFICIENT MICE ; SKIN ; APOPTOSIS ; INSULIN
英文摘要

Healing is delayed in diabetic wounds. We previously demonstrated that lineage-specific Foxo1 deletion in keratinocytes interfered with normal wound healing and keratinocyte migration. Surprisingly, the same deletion of Foxo1 in diabetic wounds had the opposite effect, significantly improving the healing response. In normal glucose media, forkhead box O1 (FOXO1) enhanced keratinocyte migration through up-regulating TGF beta 1. In high glucose, FOXO1 nuclear localization was induced but FOXO1 did not bind to the TGF beta 1 promoter or stimulate TGF beta 1 transcription. Instead, in high glucose, FOXO1 enhanced expression of serpin peptidase inhibitor, clade B (ovalbumin), member 2 (SERPINB2), and chemokine (C-C motif) ligand 20 (CCL20). The impact of high glucose on keratinocyte migration was rescued by silencing FOXO1, by reducing SERPINB2 or CCL20, or by insulin treatment. In addition, an advanced glycation end product and tumor necrosis factor had a similar regulatory effect on FOXO1 and its downstream targets and inhibited keratinocyte migration in a FOXO1-dependent manner. Thus, FOXO1 expression can positively or negatively modulate keratinocyte migration and wound healing by its differential effect on downstream targets modulated by factors present in diabetic healing.

语种英语
WOS记录号WOS:000354012800013
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被引频次:20[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63333
专题北京大学口腔医学院_口腔预防保健科
作者单位1.Peking Univ, Sch & Hosp Stomatol, Dept Prevent Dent, Beijing 100081, Peoples R China
2.Univ Penn, Sch Dent Med, Dept Periodont, Philadelphia, PA 19104 USA
3.Dalian Univ Technol, Sch Life Sci & Biotechnol, Dalian 116024, Peoples R China
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GB/T 7714
Zhang, Chenying,Ponugoti, Bhaskar,Tian, Chen,et al. FOXO1 differentially regulates both normal and diabetic wound healing[J]. JOURNAL OF CELL BIOLOGY,2015,209(2):289-303.
APA Zhang, Chenying.,Ponugoti, Bhaskar.,Tian, Chen.,Xu, Fanxing.,Tarapore, Rohinton.,...&Graves, Dana T..(2015).FOXO1 differentially regulates both normal and diabetic wound healing.JOURNAL OF CELL BIOLOGY,209(2),289-303.
MLA Zhang, Chenying,et al."FOXO1 differentially regulates both normal and diabetic wound healing".JOURNAL OF CELL BIOLOGY 209.2(2015):289-303.
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