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学科主题: 口腔医学
题名:
FOXO1 differentially regulates both normal and diabetic wound healing
作者: Zhang, Chenying1,2; Ponugoti, Bhaskar2; Tian, Chen2; Xu, Fanxing2,3; Tarapore, Rohinton2; Batres, Angelika2; Alsadun, Sarah2; Lim, Jason2; Dong, Guangyu2; Graves, Dana T.2
刊名: JOURNAL OF CELL BIOLOGY
发表日期: 2015-04-27
DOI: 10.1083/jcb.201409032
卷: 209, 期:2, 页:289-303
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cell Biology
研究领域[WOS]: Cell Biology
关键词[WOS]: GLYCATION END-PRODUCTS ; NECROSIS-FACTOR-ALPHA ; GROWTH-FACTOR-BETA ; CELL-MIGRATION ; KERATINOCYTE MIGRATION ; TRANSCRIPTION FACTORS ; DEFICIENT MICE ; SKIN ; APOPTOSIS ; INSULIN
英文摘要:

Healing is delayed in diabetic wounds. We previously demonstrated that lineage-specific Foxo1 deletion in keratinocytes interfered with normal wound healing and keratinocyte migration. Surprisingly, the same deletion of Foxo1 in diabetic wounds had the opposite effect, significantly improving the healing response. In normal glucose media, forkhead box O1 (FOXO1) enhanced keratinocyte migration through up-regulating TGF beta 1. In high glucose, FOXO1 nuclear localization was induced but FOXO1 did not bind to the TGF beta 1 promoter or stimulate TGF beta 1 transcription. Instead, in high glucose, FOXO1 enhanced expression of serpin peptidase inhibitor, clade B (ovalbumin), member 2 (SERPINB2), and chemokine (C-C motif) ligand 20 (CCL20). The impact of high glucose on keratinocyte migration was rescued by silencing FOXO1, by reducing SERPINB2 or CCL20, or by insulin treatment. In addition, an advanced glycation end product and tumor necrosis factor had a similar regulatory effect on FOXO1 and its downstream targets and inhibited keratinocyte migration in a FOXO1-dependent manner. Thus, FOXO1 expression can positively or negatively modulate keratinocyte migration and wound healing by its differential effect on downstream targets modulated by factors present in diabetic healing.

语种: 英语
WOS记录号: WOS:000354012800013
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63333
Appears in Collections:北京大学口腔医学院_口腔预防保健科_期刊论文

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作者单位: 1.Peking Univ, Sch & Hosp Stomatol, Dept Prevent Dent, Beijing 100081, Peoples R China
2.Univ Penn, Sch Dent Med, Dept Periodont, Philadelphia, PA 19104 USA
3.Dalian Univ Technol, Sch Life Sci & Biotechnol, Dalian 116024, Peoples R China

Recommended Citation:
Zhang, Chenying,Ponugoti, Bhaskar,Tian, Chen,et al. FOXO1 differentially regulates both normal and diabetic wound healing[J]. JOURNAL OF CELL BIOLOGY,2015,209(2):289-303.
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