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Plasma Homocysteine and Gene Polymorphisms Associated with the Risk of Hyperlipidemia in Northern Chinese Subjects
Huang, Lei; Song, Xiao-Ming; Zhu, Wen-Li; Li, Yong
关键词Methylenetetra hydrofolate reductase Methionine synthase Gene polymorphism Homocysteine Hyperlipidemia
刊名BIOMEDICAL AND ENVIRONMENTAL SCIENCES
2008-12-01
21期:6页:514-520
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Environmental Sciences ; Public, Environmental & Occupational Health
资助者Beijing Natural Science Foundation, China ; Beijing Natural Science Foundation, China
研究领域[WOS]Environmental Sciences & Ecology ; Public, Environmental & Occupational Health
关键词[WOS]METHYLENETETRAHYDROFOLATE REDUCTASE GENE ; METHIONINE SYNTHASE REDUCTASE ; CORONARY-HEART-DISEASE ; ADENOSYL-L-METHIONINE ; VASCULAR-DISEASE ; CARDIOVASCULAR RISK ; MUTATION ; HYPERHOMOCYSTEINEMIA ; METAANALYSIS ; CHOLESTEROL
英文摘要

Objective To examine the relationship between occurrence of hyperlipidemia. plasma homocysteine and polymorphisms of methyleneletra hydrotblate reductase (MTHFR) gene and methionine synthase (MS) gene. Methods A total of 192 hyperlipidemia patients were selected and divided into hypercholesterolemia group, hypertriglyceridemia group. and combined hyperlipidemia group. Another 208 normal individuals were selected as control. Total plasma homocysteine (tHcy) concentration was measured by high-performance liquid chromatography (HPLC). Lipid profiles were measured for all Subjects. The polymorphisms of MTHFR gene C677T and MS gene A2756G were analyzed by PCR-RFLP. Results The tHcy concentration in the combined hyperlipidemia patients was significantly higher than that in the control ( 15.95 mu mol/L vs 13.43 mu mol/L, P<0.05). The prevalence of hyperhomocysteinemia (HHcy) in the combined hyperlipidemia group was significantly higher than that in the control (42.2% vs 23.0%, P=0.015), with the odds ratio (OR) of 3.339 (95%Cl: 1.260-8.849). The hyperlipidemia patients with HHcy had a higher concentration of total cholesterol (TC) than that in the normal tHcy patients (5.67 +/- 0.95 mmol/L vs 5.47 +/- 0.92 mmol/L, P=0.034). There was no significant difference in genotype or allele frequencies of MTHFR C677T between the hyperlipidemic and control groups. The hyperlipidemia patients with MTHFR CT/TT genotype had a higher concentration of triglyceride (TG) than those with CC genotype (2.24 +/- 1.75 mmol/L vs 1.87 +/- 0.95 mmol/L. P<0.05). Individuals with CT/TT genotype had a higher concentration of tHcy than those with 677CC genotype both in the hyperlipidemia group (12.61 +/- 1.24 mu mol/L vs 11.20 +/- 1.37 mu mol/L. P<0.05) and in the control group (14.04 +/- 1.48 mu mol/L vs 12.61 +/- 1.24 mu mol/L, P<0.05). The percentage of MS 2756 GG/AG genotype in the combined hyperlipidemia group was significantly higher than that in the control (26.7% vs 13.0%, P=0.012). with the OR of 3.121 (95%Cl: 1.288-7.651). The hyperlipidemia patients with MS 2756AG/GG genotype had a higher concentration of TC (5.87 +/- 0.89 mmol/L vs 5.46 +/- 0.93 mmol/L. P<0.05) and LDL-C (3.29 +/- 0.81mmol/L vs 2.94 +/- 0.85 mmol/L, P<0.05) than those with AA genotype. However. individuals with 2756AG/GG genotype showed no significant difference in tHcy among those with AA genotype. Conclusion HHcy and MS A2756G mutation may be the risk factors for combined hyperlipidemia. Further Study is needed to confirm the role of HHcy and MS A2756G Mutation in the development of hyperlipidemia.

语种英语
所属项目编号7072044
资助者Beijing Natural Science Foundation, China ; Beijing Natural Science Foundation, China
WOS记录号WOS:000262022700011
引用统计
被引频次:23[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63338
专题北京大学公共卫生学院
作者单位Peking Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Huang, Lei,Song, Xiao-Ming,Zhu, Wen-Li,et al. Plasma Homocysteine and Gene Polymorphisms Associated with the Risk of Hyperlipidemia in Northern Chinese Subjects[J]. BIOMEDICAL AND ENVIRONMENTAL SCIENCES,2008,21(6):514-520.
APA Huang, Lei,Song, Xiao-Ming,Zhu, Wen-Li,&Li, Yong.(2008).Plasma Homocysteine and Gene Polymorphisms Associated with the Risk of Hyperlipidemia in Northern Chinese Subjects.BIOMEDICAL AND ENVIRONMENTAL SCIENCES,21(6),514-520.
MLA Huang, Lei,et al."Plasma Homocysteine and Gene Polymorphisms Associated with the Risk of Hyperlipidemia in Northern Chinese Subjects".BIOMEDICAL AND ENVIRONMENTAL SCIENCES 21.6(2008):514-520.
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