IR@PKUHSC  > 北京大学临床肿瘤学院
学科主题临床医学
Synthesis and preliminary biological evaluation of the Tc-99m labeled nitrobenzoimidazole and nitrotriazole as tumor hypoxia markers
Zhang, Y; Chu, TW; Gao, XG; Liu, XQ; Yang, Z; Guo, ZQ; Wang, XY
关键词hypoxia nitrobenzoimidazole nitrotriazole tumor labeling
刊名BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
2006-04-01
DOI10.1016/j.bmcl.2006.01.001
16期:7页:1831-1833
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Medicinal ; Chemistry, Organic
研究领域[WOS]Pharmacology & Pharmacy ; Chemistry
关键词[WOS]TC-99M-LABELED 2-NITROIMIDAZOLE ; IMAGING HYPOXIA
英文摘要

1-(3-1 2,4-Nitrotriazole-1-yl)-propanhydroxyiminoamide and 1-(6-nitrobenzoimidazole-1-yl)-propanhydroxyiminoamide were synthesized and radiolabeled with Tc-99m. The Tc-99m labeled complexes continuously accumulated in hypoxic marine sarcoma S180 cells in vitro but not in aerobic cells. Biodistribution results in mice bearing S180 tumor indicated that the tracers could localize in tumor and eliminate from it slowly. These results suggested that the Tc-99m labeled nitrobenzoimidazole and nitrotriazole might be the novel tumor hypoxia markers. (C) 2006 Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000236402500013
引用统计
被引频次:25[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63348
专题北京大学临床肿瘤学院
作者单位1.Peking Univ, Sch Oncol, Beijing 100036, Peoples R China
2.Beijing Inst Canc Res, Beijing 100036, Peoples R China
3.Peking Univ, Coll Life Sci, Beijing 100871, Peoples R China
4.Peking Univ, Coll Chem & Mol Engn, Dept Appl Chem, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Zhang, Y,Chu, TW,Gao, XG,et al. Synthesis and preliminary biological evaluation of the Tc-99m labeled nitrobenzoimidazole and nitrotriazole as tumor hypoxia markers[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2006,16(7):1831-1833.
APA Zhang, Y.,Chu, TW.,Gao, XG.,Liu, XQ.,Yang, Z.,...&Wang, XY.(2006).Synthesis and preliminary biological evaluation of the Tc-99m labeled nitrobenzoimidazole and nitrotriazole as tumor hypoxia markers.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,16(7),1831-1833.
MLA Zhang, Y,et al."Synthesis and preliminary biological evaluation of the Tc-99m labeled nitrobenzoimidazole and nitrotriazole as tumor hypoxia markers".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 16.7(2006):1831-1833.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Zhang, Y]的文章
[Chu, TW]的文章
[Gao, XG]的文章
百度学术
百度学术中相似的文章
[Zhang, Y]的文章
[Chu, TW]的文章
[Gao, XG]的文章
必应学术
必应学术中相似的文章
[Zhang, Y]的文章
[Chu, TW]的文章
[Gao, XG]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。