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学科主题: 临床医学
题名:
Synthesis and preliminary biological evaluation of the Tc-99m labeled nitrobenzoimidazole and nitrotriazole as tumor hypoxia markers
作者: Zhang, Y; Chu, TW; Gao, XG; Liu, XQ; Yang, Z; Guo, ZQ; Wang, XY
关键词: hypoxia ; nitrobenzoimidazole ; nitrotriazole ; tumor ; labeling
刊名: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
发表日期: 2006-04-01
DOI: 10.1016/j.bmcl.2006.01.001
卷: 16, 期:7, 页:1831-1833
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Medicinal ; Chemistry, Organic
研究领域[WOS]: Pharmacology & Pharmacy ; Chemistry
关键词[WOS]: TC-99M-LABELED 2-NITROIMIDAZOLE ; IMAGING HYPOXIA
英文摘要:

1-(3-1 2,4-Nitrotriazole-1-yl)-propanhydroxyiminoamide and 1-(6-nitrobenzoimidazole-1-yl)-propanhydroxyiminoamide were synthesized and radiolabeled with Tc-99m. The Tc-99m labeled complexes continuously accumulated in hypoxic marine sarcoma S180 cells in vitro but not in aerobic cells. Biodistribution results in mice bearing S180 tumor indicated that the tracers could localize in tumor and eliminate from it slowly. These results suggested that the Tc-99m labeled nitrobenzoimidazole and nitrotriazole might be the novel tumor hypoxia markers. (C) 2006 Elsevier Ltd. All rights reserved.

语种: 英语
WOS记录号: WOS:000236402500013
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63348
Appears in Collections:北京大学临床肿瘤学院_期刊论文

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作者单位: 1.Peking Univ, Sch Oncol, Beijing 100036, Peoples R China
2.Beijing Inst Canc Res, Beijing 100036, Peoples R China
3.Peking Univ, Coll Life Sci, Beijing 100871, Peoples R China
4.Peking Univ, Coll Chem & Mol Engn, Dept Appl Chem, Beijing 100871, Peoples R China

Recommended Citation:
Zhang, Y,Chu, TW,Gao, XG,et al. Synthesis and preliminary biological evaluation of the Tc-99m labeled nitrobenzoimidazole and nitrotriazole as tumor hypoxia markers[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2006,16(7):1831-1833.
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