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学科主题: 临床医学
题名:
Persistence of Rabies Antibody 5 Years after Postexposure Prophylaxis with Vero Cell Antirabies Vaccine and Antibody Response to a Single Booster Dose
作者: Zhang, Xiaowei2; Zhu, Zhenggang3; Wang, Chuanlin1
刊名: CLINICAL AND VACCINE IMMUNOLOGY
发表日期: 2011-09-01
DOI: 10.1128/CVI.05090-11
卷: 18, 期:9, 页:1477-1479
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Immunology ; Infectious Diseases ; Microbiology
研究领域[WOS]: Immunology ; Infectious Diseases ; Microbiology
关键词[WOS]: CHINA
英文摘要:

This study was done to investigate the antibody response to a Vero cell antirabies vaccine, the persistence of antibody for 5 years, and the effect of a booster dose after this interval. From August 2005 to February 2011, a total of 195 patients were enrolled into our study due to an animal bite. The Essen intramuscular (i. m.) regimen, which is recommended by the WHO for modern vaccines used in postexposure treatment, was adopted in this study. Blood samples were obtained on day 0, day 7, day 14, day 45, year 1, year 2, year 3, year 4, year 5, and year 5 plus 14 days. Immunogenicity was evaluated by the titration of neutralizing antibodies with a rapid fluorescent focus inhibition test (RFFIT). Seroconversion was expressed as the seroconversion rate (SCR). A secondary quantitative evaluation criterion, other than the seroconversion level, was the geometric mean titer (GMT). Of the 195 enrolled patients, 168 (86.4%) of them completed the whole study. No serious adverse reactions to the vaccine were reported during vaccination, the 5-year follow-up period, or revaccination. On day 14, the rabies antibody GMT value was 8.87 IU/ml in the vaccinees. During the next 5 years, the SCR in the ChengDa vaccine group gradually decreased to 34.0% at year 5, down from 90.5% at year 1. There was a significant booster effect: the GMT was 15.22 IU/ml on year 5 plus 14 days. Our findings demonstrate that the ChengDa rabies vaccine offers an alternative with a high degree of efficacy and yet limited side effects and ensures that the exposed patient will be on the safe side of the risk of rabies by the 14th day. Moreover, when followed by a booster dose 5 years later, it could boost the immunity. A further booster is effective in inducing a good neutralizing antibody response even after an interval of 5 years.

语种: 英语
所属项目编号: RDB 2009-26
项目资助者: Beijing University People&prime ; s Hospital ; Peking University People&prime ; s Hospital
WOS记录号: WOS:000294452800013
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63351
Appears in Collections:北京大学第二临床医学院_急诊科_期刊论文

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作者单位: 1.Peking Univ, Peoples Hosp, Dept Urol, Beijing, Peoples R China
2.Wuhan Ctr Dis Prevent & Control, Wuhan, Peoples R China
3.Peking Univ, Peoples Hosp, Emergency Dept, Beijing, Peoples R China

Recommended Citation:
Zhang, Xiaowei,Zhu, Zhenggang,Wang, Chuanlin. Persistence of Rabies Antibody 5 Years after Postexposure Prophylaxis with Vero Cell Antirabies Vaccine and Antibody Response to a Single Booster Dose[J]. CLINICAL AND VACCINE IMMUNOLOGY,2011,18(9):1477-1479.
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