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学科主题: 临床医学
题名:
Effects of Remifemin Treatment on Bone Integrity and Remodeling in Rats with Ovariectomy-Induced Osteoporosis
作者: Cui, Guangxia1; Leng, Huijie2; Wang, Ke3; Wang, Jianwei3; Zhu, Sainan4; Jia, Jing5; Chen, Xing1; Zhang, Weiguang3; Qin, Lihua3; Bai, Wenpei1
刊名: PLOS ONE
发表日期: 2013-12-09
DOI: 10.1371/journal.pone.0082815
卷: 8, 期:12
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: BLACK COHOSH EXTRACT ; HORMONE REPLACEMENT THERAPY ; CIMICIFUGA-RACEMOSA ; POSTMENOPAUSAL OSTEOPOROSIS ; ISOPROPANOLIC EXTRACT ; MENOPAUSAL SYMPTOMS ; MODEL ; WOMEN ; ESTROGEN ; BISPHOSPHONATES
英文摘要:

This study aims to evaluate the effects of Remifemin (isopropanolic extract of Cimicifuga Racemosa) on postmenopausal osteoporosis. 120 female Sprague-Dawley rats were randomly assigned to four groups: sham surgery with vehicle, ovariectomy with vehicle, ovariectomy with estradiol valerate, or ovariectomy with Remifemin. Daily oral administrations of the vehicle, estradiol valerate, or Remifemin began 2 weeks after surgery and lasted to 4, 8, or 12 weeks. Ten rats in each group were sacrificed at each timestep with assessment of bone mineral density, trabecular bone structure, and biomechanical parameters of the femur and lumbar vertebra. Bone turnover markers were evaluated 12 weeks after surgery. Both drugs prevented bone density loss in the distal end of the femur and preserved the trabecular bone structure in both the lumbar vertebra and distal end of the femur following ovariectomy. Both drugs protected bone stiffness at the tested regions and reduced bone reabsorption in ovariectomized rats. The preventive effects of Remifemin against bone-loss can rival those of estradiol valerate if treatment duration is adequately extended. In conclusion, Remifemin may demonstrate equivalent effects to estradiol valerate in terms of preventing postmenopausal osteoporosis.

语种: 英语
所属项目编号: NSFC 11002004
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000328705200102
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63362
Appears in Collections:北京大学第一临床医学院_期刊论文

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作者单位: 1.Peking Univ, Hosp 1, Dept Obstet & Gynecol, Beijing 100871, Peoples R China
2.Peking Univ, Hosp 3, Dept Orthopaed, Beijing 100871, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Dept Anat & Embryol, Beijing 100871, Peoples R China
4.Peking Univ, Hosp 1, Stat Off, Beijing 100871, Peoples R China
5.Gen Hosp Armed Police, Dept Stomatol, Beijing, Peoples R China

Recommended Citation:
Cui, Guangxia,Leng, Huijie,Wang, Ke,et al. Effects of Remifemin Treatment on Bone Integrity and Remodeling in Rats with Ovariectomy-Induced Osteoporosis[J]. PLOS ONE,2013,8(12).
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