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学科主题临床医学
Effects of Remifemin Treatment on Bone Integrity and Remodeling in Rats with Ovariectomy-Induced Osteoporosis
Cui, Guangxia1; Leng, Huijie2; Wang, Ke3; Wang, Jianwei3; Zhu, Sainan4; Jia, Jing5; Chen, Xing1; Zhang, Weiguang3; Qin, Lihua3; Bai, Wenpei1
刊名PLOS ONE
2013-12-09
DOI10.1371/journal.pone.0082815
8期:12
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]BLACK COHOSH EXTRACT ; HORMONE REPLACEMENT THERAPY ; CIMICIFUGA-RACEMOSA ; POSTMENOPAUSAL OSTEOPOROSIS ; ISOPROPANOLIC EXTRACT ; MENOPAUSAL SYMPTOMS ; MODEL ; WOMEN ; ESTROGEN ; BISPHOSPHONATES
英文摘要

This study aims to evaluate the effects of Remifemin (isopropanolic extract of Cimicifuga Racemosa) on postmenopausal osteoporosis. 120 female Sprague-Dawley rats were randomly assigned to four groups: sham surgery with vehicle, ovariectomy with vehicle, ovariectomy with estradiol valerate, or ovariectomy with Remifemin. Daily oral administrations of the vehicle, estradiol valerate, or Remifemin began 2 weeks after surgery and lasted to 4, 8, or 12 weeks. Ten rats in each group were sacrificed at each timestep with assessment of bone mineral density, trabecular bone structure, and biomechanical parameters of the femur and lumbar vertebra. Bone turnover markers were evaluated 12 weeks after surgery. Both drugs prevented bone density loss in the distal end of the femur and preserved the trabecular bone structure in both the lumbar vertebra and distal end of the femur following ovariectomy. Both drugs protected bone stiffness at the tested regions and reduced bone reabsorption in ovariectomized rats. The preventive effects of Remifemin against bone-loss can rival those of estradiol valerate if treatment duration is adequately extended. In conclusion, Remifemin may demonstrate equivalent effects to estradiol valerate in terms of preventing postmenopausal osteoporosis.

语种英语
WOS记录号WOS:000328705200102
引用统计
被引频次:11[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63362
专题北京大学第一临床医学院
北京大学基础医学院
北京大学第一临床医学院_医学统计室
作者单位1.Peking Univ, Hosp 1, Dept Obstet & Gynecol, Beijing 100871, Peoples R China
2.Peking Univ, Hosp 3, Dept Orthopaed, Beijing 100871, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Dept Anat & Embryol, Beijing 100871, Peoples R China
4.Peking Univ, Hosp 1, Stat Off, Beijing 100871, Peoples R China
5.Gen Hosp Armed Police, Dept Stomatol, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Cui, Guangxia,Leng, Huijie,Wang, Ke,et al. Effects of Remifemin Treatment on Bone Integrity and Remodeling in Rats with Ovariectomy-Induced Osteoporosis[J]. PLOS ONE,2013,8(12).
APA Cui, Guangxia.,Leng, Huijie.,Wang, Ke.,Wang, Jianwei.,Zhu, Sainan.,...&Bai, Wenpei.(2013).Effects of Remifemin Treatment on Bone Integrity and Remodeling in Rats with Ovariectomy-Induced Osteoporosis.PLOS ONE,8(12).
MLA Cui, Guangxia,et al."Effects of Remifemin Treatment on Bone Integrity and Remodeling in Rats with Ovariectomy-Induced Osteoporosis".PLOS ONE 8.12(2013).
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