北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学公共卫生学院  > 期刊论文
学科主题: 公共卫生
题名:
Acute toxicological effects of copper nanoparticles in vivo
作者: Chen, Z; Meng, HA; Xing, GM; Chen, CY; Zhao, YL; Jia, GA; Wang, TC; Yuan, H; Ye, C; Zhao, F; Chai, ZF; Zhu, CF; Fang, XH; Ma, BC; Wan, LJ
关键词: nanotoxicity ; LD(50) ; target organs ; copper nanoparticles ; in vivo
刊名: TOXICOLOGY LETTERS
发表日期: 2006-05-25
DOI: 10.1016/j.toxlet.2005.10.003
卷: 163, 期:2, 页:109-120
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Toxicology
研究领域[WOS]: Toxicology
关键词[WOS]: GASTROINTESTINAL MUCOSA ; TITANIUM-DIOXIDE ; TOXICITY ; TRANSLOCATION ; GLUTATHIONE ; PARTICLES ; DISEASE ; DIET
英文摘要:

To assess the toxicity of copper nanoparticles (23.5 nm) in vivo, LD(50), morphological changes, pathological examinations and blood biochemical indexes of experimental mice are studied comparatively with micro-copper particles (17 mu m) and cupric ions (CuCl(2)center dot 2H(2)O). The LD(50) for the nano-, micro-copper particles and cupric ions exposed to mice via oral gavage are 413, > 5000 and 110 mg/kg body weight, respectively. The toxicity classes of nano and ionic copper particles both are class 3 (moderately toxic), and micro-copper is class 5 (practically non-toxic) of Hodge and Sterner Scale. Kidney, liver and spleen are found to be target organs of nano-copper particles. Nanoparticles induce gravely toxicological effects and heavy injuries on kidney. liver and spleen of experimental mice, but micro-copper particles do not, on mass basis. Results indicate a gender dependent feature of nanotoxicity. Several factors such as huge specific Surface area, ultrahigh reactivity, exceeding consumption of H(+), etc. that likely cause the grave nanotoxicity observed in vivo are discussed. (c) 2005 Elsevier Ireland Ltd. All rights reserved.

语种: 英语
WOS记录号: WOS:000236820200004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63370
Appears in Collections:北京大学公共卫生学院_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Chinese Acad Sci, Lab Bioenvironm Hlth Sci Nanoscale Mat, Beijing 100049, Peoples R China
2.Peking Univ, Sch Publ Hlth, Dept Occupat & Environm Hlth Sci, Beijing 100083, Peoples R China
3.Chinese Acad Sci, Inst Chem, Key Lab Mol Nanostruct & Nanotechnol, Beijing 100080, Peoples R China
4.Peking Univ, Hosp 3, Sch Publ Hlth, Dept Clin Lab, Beijing 100083, Peoples R China
5.Chinese Acad Sci, Grad Sch, Beijing 100864, Peoples R China

Recommended Citation:
Chen, Z,Meng, HA,Xing, GM,et al. Acute toxicological effects of copper nanoparticles in vivo[J]. TOXICOLOGY LETTERS,2006,163(2):109-120.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Chen, Z]'s Articles
[Meng, HA]'s Articles
[Xing, GM]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Chen, Z]‘s Articles
[Meng, HA]‘s Articles
[Xing, GM]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2018  北京大学医学部 - Feedback
Powered by CSpace