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Acute toxicological effects of copper nanoparticles in vivo
Chen, Z; Meng, HA; Xing, GM; Chen, CY; Zhao, YL; Jia, GA; Wang, TC; Yuan, H; Ye, C; Zhao, F; Chai, ZF; Zhu, CF; Fang, XH; Ma, BC; Wan, LJ
关键词nanotoxicity LD(50) target organs copper nanoparticles in vivo
刊名TOXICOLOGY LETTERS
2006-05-25
DOI10.1016/j.toxlet.2005.10.003
163期:2页:109-120
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Toxicology
研究领域[WOS]Toxicology
关键词[WOS]GASTROINTESTINAL MUCOSA ; TITANIUM-DIOXIDE ; TOXICITY ; TRANSLOCATION ; GLUTATHIONE ; PARTICLES ; DISEASE ; DIET
英文摘要

To assess the toxicity of copper nanoparticles (23.5 nm) in vivo, LD(50), morphological changes, pathological examinations and blood biochemical indexes of experimental mice are studied comparatively with micro-copper particles (17 mu m) and cupric ions (CuCl(2)center dot 2H(2)O). The LD(50) for the nano-, micro-copper particles and cupric ions exposed to mice via oral gavage are 413, > 5000 and 110 mg/kg body weight, respectively. The toxicity classes of nano and ionic copper particles both are class 3 (moderately toxic), and micro-copper is class 5 (practically non-toxic) of Hodge and Sterner Scale. Kidney, liver and spleen are found to be target organs of nano-copper particles. Nanoparticles induce gravely toxicological effects and heavy injuries on kidney. liver and spleen of experimental mice, but micro-copper particles do not, on mass basis. Results indicate a gender dependent feature of nanotoxicity. Several factors such as huge specific Surface area, ultrahigh reactivity, exceeding consumption of H(+), etc. that likely cause the grave nanotoxicity observed in vivo are discussed. (c) 2005 Elsevier Ireland Ltd. All rights reserved.

语种英语
WOS记录号WOS:000236820200004
引用统计
被引频次:450[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63370
专题北京大学公共卫生学院
作者单位1.Chinese Acad Sci, Lab Bioenvironm Hlth Sci Nanoscale Mat, Beijing 100049, Peoples R China
2.Peking Univ, Sch Publ Hlth, Dept Occupat & Environm Hlth Sci, Beijing 100083, Peoples R China
3.Chinese Acad Sci, Inst Chem, Key Lab Mol Nanostruct & Nanotechnol, Beijing 100080, Peoples R China
4.Peking Univ, Hosp 3, Sch Publ Hlth, Dept Clin Lab, Beijing 100083, Peoples R China
5.Chinese Acad Sci, Grad Sch, Beijing 100864, Peoples R China
推荐引用方式
GB/T 7714
Chen, Z,Meng, HA,Xing, GM,et al. Acute toxicological effects of copper nanoparticles in vivo[J]. TOXICOLOGY LETTERS,2006,163(2):109-120.
APA Chen, Z.,Meng, HA.,Xing, GM.,Chen, CY.,Zhao, YL.,...&Wan, LJ.(2006).Acute toxicological effects of copper nanoparticles in vivo.TOXICOLOGY LETTERS,163(2),109-120.
MLA Chen, Z,et al."Acute toxicological effects of copper nanoparticles in vivo".TOXICOLOGY LETTERS 163.2(2006):109-120.
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