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Meta-analysis of the relationship between the LOC387715/ARMS2 polymorphism and polypoidal choroidal vasculopathy
Jiang, J. J.1,2; Wu, X.1; Zhou, P.1,3; Yu, W. Z.1; Huang, L. Z.1; Li, X. X.1
关键词Polypoidal choroidal vasculopathy LOC387715/ARMS2 Gene polymorphism Meta-analysis
刊名GENETICS AND MOLECULAR RESEARCH
2012
DOI10.4238/2012.December.17.1
11期:4页:4256-4267
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Genetics & Heredity
研究领域[WOS]Biochemistry & Molecular Biology ; Genetics & Heredity
关键词[WOS]HTRA1 PROMOTER POLYMORPHISM ; AGE-RELATED MACULOPATHY ; MACULAR DEGENERATION ; CLINICAL CHARACTERISTICS ; CIGARETTE-SMOKING ; VISUAL PROGNOSIS ; ASSOCIATION ; CFH ; JAPANESE ; GENE
英文摘要

We investigated the association between the LOC387715/ARMS2 polymorphism (rs10490924 G>T) and susceptibility to polypoidal choroidal vasculopathy (PCV) through a meta-analysis of 1446 cases and 3255 controls from eight case-control studies. The genetic effect of the LOC387715/ARMS2 rs10490924 G>T polymorphism on PCV was assessed by calculating pooled odds ratios (ORs) with 95% confidence intervals (95% CIs). We found that elevated PCV risk was significantly associated with the GG genotype (GG vs TT, OR = 4.23, 95%CI = 3.53-5.06), and heterozygous genotype TG appeared to have a minor effect on PCV risk (TG vs TT, OR = 1.47, 95% CI = 1.26-1.71). Patients with the T allele were 2.09 times more likely to have PCV than those with the G allele (95% CI = 1.906-2.288). A further subgroup analysis by ages also showed that the genetic effect of the LOC387715/ARMS2 rs10490924 G>T polymorphism on PCV is stronger among patients with mean age <73 years. Our meta-analysis strengthened the evidence that the LOC387715/ARMS2 rs10490924 G>T polymorphism plays an important role in PCV susceptibility.

语种英语
WOS记录号WOS:000313960500070
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63373
专题北京大学第二临床医学院_眼科
北京大学护理学院_护理学院
作者单位1.Peking Univ, Dept Ophthalmol, Peoples Hosp, Beijing 100871, Peoples R China
2.China Japan Friendship Hosp, Dept Ophthalmol, Beijing, Peoples R China
3.Fudan Univ, Dept Ophthalmol, Eye & ENT Hosp, Shanghai 200433, Peoples R China
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GB/T 7714
Jiang, J. J.,Wu, X.,Zhou, P.,et al. Meta-analysis of the relationship between the LOC387715/ARMS2 polymorphism and polypoidal choroidal vasculopathy[J]. GENETICS AND MOLECULAR RESEARCH,2012,11(4):4256-4267.
APA Jiang, J. J.,Wu, X.,Zhou, P.,Yu, W. Z.,Huang, L. Z.,&Li, X. X..(2012).Meta-analysis of the relationship between the LOC387715/ARMS2 polymorphism and polypoidal choroidal vasculopathy.GENETICS AND MOLECULAR RESEARCH,11(4),4256-4267.
MLA Jiang, J. J.,et al."Meta-analysis of the relationship between the LOC387715/ARMS2 polymorphism and polypoidal choroidal vasculopathy".GENETICS AND MOLECULAR RESEARCH 11.4(2012):4256-4267.
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