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学科主题: 临床医学
题名:
Meta-analysis of the relationship between the LOC387715/ARMS2 polymorphism and polypoidal choroidal vasculopathy
作者: Jiang, J. J.1,2; Wu, X.1; Zhou, P.1,3; Yu, W. Z.1; Huang, L. Z.1; Li, X. X.1
关键词: Polypoidal choroidal vasculopathy ; LOC387715/ARMS2 ; Gene polymorphism ; Meta-analysis
刊名: GENETICS AND MOLECULAR RESEARCH
发表日期: 2012
DOI: 10.4238/2012.December.17.1
卷: 11, 期:4, 页:4256-4267
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Genetics & Heredity
研究领域[WOS]: Biochemistry & Molecular Biology ; Genetics & Heredity
关键词[WOS]: HTRA1 PROMOTER POLYMORPHISM ; AGE-RELATED MACULOPATHY ; MACULAR DEGENERATION ; CLINICAL CHARACTERISTICS ; CIGARETTE-SMOKING ; VISUAL PROGNOSIS ; ASSOCIATION ; CFH ; JAPANESE ; GENE
英文摘要:

We investigated the association between the LOC387715/ARMS2 polymorphism (rs10490924 G>T) and susceptibility to polypoidal choroidal vasculopathy (PCV) through a meta-analysis of 1446 cases and 3255 controls from eight case-control studies. The genetic effect of the LOC387715/ARMS2 rs10490924 G>T polymorphism on PCV was assessed by calculating pooled odds ratios (ORs) with 95% confidence intervals (95% CIs). We found that elevated PCV risk was significantly associated with the GG genotype (GG vs TT, OR = 4.23, 95%CI = 3.53-5.06), and heterozygous genotype TG appeared to have a minor effect on PCV risk (TG vs TT, OR = 1.47, 95% CI = 1.26-1.71). Patients with the T allele were 2.09 times more likely to have PCV than those with the G allele (95% CI = 1.906-2.288). A further subgroup analysis by ages also showed that the genetic effect of the LOC387715/ARMS2 rs10490924 G>T polymorphism on PCV is stronger among patients with mean age <73 years. Our meta-analysis strengthened the evidence that the LOC387715/ARMS2 rs10490924 G>T polymorphism plays an important role in PCV susceptibility.

语种: 英语
所属项目编号: 2011CB510200
项目资助者: National Basic Research Program of China (973 Program)
WOS记录号: WOS:000313960500070
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63373
Appears in Collections:北京大学第二临床医学院_眼科_期刊论文

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作者单位: 1.Peking Univ, Dept Ophthalmol, Peoples Hosp, Beijing 100871, Peoples R China
2.China Japan Friendship Hosp, Dept Ophthalmol, Beijing, Peoples R China
3.Fudan Univ, Dept Ophthalmol, Eye & ENT Hosp, Shanghai 200433, Peoples R China

Recommended Citation:
Jiang, J. J.,Wu, X.,Zhou, P.,et al. Meta-analysis of the relationship between the LOC387715/ARMS2 polymorphism and polypoidal choroidal vasculopathy[J]. GENETICS AND MOLECULAR RESEARCH,2012,11(4):4256-4267.
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