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Hyperphosphatemia-induced hyperparathyroidism in 5/6 nephrectomized rats: development of a new animal model
Jiang Ying; Wang Mei
关键词hyperphosphatemia kidney failure, chronic hyperparathyroidism, secondary
刊名CHINESE MEDICAL JOURNAL
2008-12-05
121期:23页:2440-2443
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
研究领域[WOS]General & Internal Medicine
关键词[WOS]CHRONIC-RENAL-FAILURE ; SECONDARY HYPERPARATHYROIDISM ; PHOSPHORUS RESTRICTION ; EXPERIMENTAL UREMIA ; PARATHYROID-GLANDS ; GENE-EXPRESSION ; PTH SECRETION ; IN-VITRO ; PREVENTION ; MILD
英文摘要

Background We require a stable model to understand the molecular mechanism by which isolated hyperphosphatemia induces hyperparathyroidism secondary to chronic renal failure. The present study established a rat model of hyperphosphatemia-induced secondary hyperparathyroidism in chronic renal failure.

Methods Twenty-nine rats with 5/6 nephrectomy (Nx) were divided into three groups and were fed for 10 weeks on a high phosphate diet (1.2% phosphate) starting from three different post-Nx time points. Parathyroid hormone mRNA in parathyroid gland was measured by real-time PCR and parathyroid cell hyperplasia was tested by proliferating cell nuclear antigen (PCNA) assay.

Results The 10 rats fed a high phosphate diet starting from the fourth week post-Nx had isolated hyperphosphatemia and excess synthesis/secretion of parathyroid hormone, and hyperplasia of the parathyroid glands were induced (r=0.86-0.97, P <0.001), but the levels of serum calcium and 1,25(OH)(2)D(3) did not change.

Conclusion A rat model of hyperphosphatemia-induced secondary hyperparathyroidism in chronic renal failure was established by 5/6 Nx and 10 weeks-high phosphate diet starting from the fourth week post-Nx.

语种英语
WOS记录号WOS:000263443300015
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63374
专题北京大学第二临床医学院_肾内科
北京大学医学部管理机构_医学部
北京大学口腔医学院_外科
作者单位Peking Univ, Peoples Hosp, Dept Nephrol, Beijing 100044, Peoples R China
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Jiang Ying,Wang Mei. Hyperphosphatemia-induced hyperparathyroidism in 5/6 nephrectomized rats: development of a new animal model[J]. CHINESE MEDICAL JOURNAL,2008,121(23):2440-2443.
APA Jiang Ying,&Wang Mei.(2008).Hyperphosphatemia-induced hyperparathyroidism in 5/6 nephrectomized rats: development of a new animal model.CHINESE MEDICAL JOURNAL,121(23),2440-2443.
MLA Jiang Ying,et al."Hyperphosphatemia-induced hyperparathyroidism in 5/6 nephrectomized rats: development of a new animal model".CHINESE MEDICAL JOURNAL 121.23(2008):2440-2443.
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