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学科主题: 临床医学
题名:
Hyperphosphatemia-induced hyperparathyroidism in 5/6 nephrectomized rats: development of a new animal model
作者: Jiang Ying; Wang Mei
关键词: hyperphosphatemia ; kidney failure, chronic ; hyperparathyroidism, secondary
刊名: CHINESE MEDICAL JOURNAL
发表日期: 2008-12-05
卷: 121, 期:23, 页:2440-2443
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: CHRONIC-RENAL-FAILURE ; SECONDARY HYPERPARATHYROIDISM ; PHOSPHORUS RESTRICTION ; EXPERIMENTAL UREMIA ; PARATHYROID-GLANDS ; GENE-EXPRESSION ; PTH SECRETION ; IN-VITRO ; PREVENTION ; MILD
英文摘要:

Background We require a stable model to understand the molecular mechanism by which isolated hyperphosphatemia induces hyperparathyroidism secondary to chronic renal failure. The present study established a rat model of hyperphosphatemia-induced secondary hyperparathyroidism in chronic renal failure.

Methods Twenty-nine rats with 5/6 nephrectomy (Nx) were divided into three groups and were fed for 10 weeks on a high phosphate diet (1.2% phosphate) starting from three different post-Nx time points. Parathyroid hormone mRNA in parathyroid gland was measured by real-time PCR and parathyroid cell hyperplasia was tested by proliferating cell nuclear antigen (PCNA) assay.

Results The 10 rats fed a high phosphate diet starting from the fourth week post-Nx had isolated hyperphosphatemia and excess synthesis/secretion of parathyroid hormone, and hyperplasia of the parathyroid glands were induced (r=0.86-0.97, P <0.001), but the levels of serum calcium and 1,25(OH)(2)D(3) did not change.

Conclusion A rat model of hyperphosphatemia-induced secondary hyperparathyroidism in chronic renal failure was established by 5/6 Nx and 10 weeks-high phosphate diet starting from the fourth week post-Nx.

语种: 英语
WOS记录号: WOS:000263443300015
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63374
Appears in Collections:北京大学第二临床医学院_肾内科_期刊论文

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作者单位: Peking Univ, Peoples Hosp, Dept Nephrol, Beijing 100044, Peoples R China

Recommended Citation:
Jiang Ying,Wang Mei. Hyperphosphatemia-induced hyperparathyroidism in 5/6 nephrectomized rats: development of a new animal model[J]. CHINESE MEDICAL JOURNAL,2008,121(23):2440-2443.
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