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Elevated Levels of Dickkopf-1 Are Associated with beta-Catenin Accumulation and Poor Prognosis in Patients with Chondrosarcoma
Chen, Changbao1; Zhou, Hua2; Zhang, Xiaolin1; Ma, Xinlong1; Liu, Zhongjun2; Liu, Xiaoguang2
刊名PLOS ONE
2014-08-21
DOI10.1371/journal.pone.0105414
9期:8
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]HYPOXIA-INDUCIBLE FACTOR-1-ALPHA ; CANCER BONE METASTASES ; HEPATOCELLULAR CARCINOMAS ; NUCLEAR ACCUMULATION ; EXPRESSION ; PROTEIN ; GENE ; DKK1 ; REGULATOR ; OSTEOSARCOMA
英文摘要

Background: Dickkopf-1 (DKK1) is an antagonist of Wnt/beta-catenin signaling implicated in tumorigenesis. However, the biological role of DKK1 and beta-catenin involved in chondrosarcoma has not been sufficiently investigated. This study was designed to investigate the expression profiles of DKK1 and beta-catenin, and to clarify their clinical values in chondrosarcoma.

Methods: The mRNA and protein levels of DKK1 and beta-catenin in fresh chondrosarcoma and the corresponding non-tumor tissues were analyzed by Real-time PCR and Western blot, respectively. The protein expression patterns of DKK1 and bcatenin were investigated by immunohistochemistry. The associations among DKK1 level, beta-catenin accumulation, clinicopathological factors and the overall survival were separately evaluated.

Results: Both DKK1 and beta-catenin levels were remarkably elevated in chondrosarcoma compared with the corresponding non-tumor tissues. High DKK1 level and positive beta-catenin accumulation in chondrosarcoma specimens were 58.7% and 53.9%, respectively. Elevated DKK1 level significantly correlated with positive beta-catenin accumulation, and they were remarkably associated with histological grade and Musculoskeletal Tumor Society stage. Furthermore, DKK1 level and bcatenin accumulation had significant impacts on the prognosis of chondrosarcoma patients. Multivariate analysis revealed that DKK1 level was an independent prognostic factor for overall survival.

Conclusions: Elevated DKK1 levels associated with beta-catenin accumulation play a crucial role in chondrosarcoma. DKK1 can serve as a novel predictor of poor prognosis in patients with chondrosarcoma.

语种英语
WOS记录号WOS:000341106100065
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63380
专题北京大学第三临床医学院_骨科
作者单位1.Tianjin Hosp, Dept Spinal Surg, Tianjin, Peoples R China
2.Peking Univ, Dept Orthopaed Surg, Hosp 3, Beijing 100871, Peoples R China
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GB/T 7714
Chen, Changbao,Zhou, Hua,Zhang, Xiaolin,et al. Elevated Levels of Dickkopf-1 Are Associated with beta-Catenin Accumulation and Poor Prognosis in Patients with Chondrosarcoma[J]. PLOS ONE,2014,9(8).
APA Chen, Changbao,Zhou, Hua,Zhang, Xiaolin,Ma, Xinlong,Liu, Zhongjun,&Liu, Xiaoguang.(2014).Elevated Levels of Dickkopf-1 Are Associated with beta-Catenin Accumulation and Poor Prognosis in Patients with Chondrosarcoma.PLOS ONE,9(8).
MLA Chen, Changbao,et al."Elevated Levels of Dickkopf-1 Are Associated with beta-Catenin Accumulation and Poor Prognosis in Patients with Chondrosarcoma".PLOS ONE 9.8(2014).
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