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学科主题: 临床医学
题名:
Elevated Levels of Dickkopf-1 Are Associated with beta-Catenin Accumulation and Poor Prognosis in Patients with Chondrosarcoma
作者: Chen, Changbao1; Zhou, Hua2; Zhang, Xiaolin1; Ma, Xinlong1; Liu, Zhongjun2; Liu, Xiaoguang2
刊名: PLOS ONE
发表日期: 2014-08-21
DOI: 10.1371/journal.pone.0105414
卷: 9, 期:8
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: HYPOXIA-INDUCIBLE FACTOR-1-ALPHA ; CANCER BONE METASTASES ; HEPATOCELLULAR CARCINOMAS ; NUCLEAR ACCUMULATION ; EXPRESSION ; PROTEIN ; GENE ; DKK1 ; REGULATOR ; OSTEOSARCOMA
英文摘要:

Background: Dickkopf-1 (DKK1) is an antagonist of Wnt/beta-catenin signaling implicated in tumorigenesis. However, the biological role of DKK1 and beta-catenin involved in chondrosarcoma has not been sufficiently investigated. This study was designed to investigate the expression profiles of DKK1 and beta-catenin, and to clarify their clinical values in chondrosarcoma.

Methods: The mRNA and protein levels of DKK1 and beta-catenin in fresh chondrosarcoma and the corresponding non-tumor tissues were analyzed by Real-time PCR and Western blot, respectively. The protein expression patterns of DKK1 and bcatenin were investigated by immunohistochemistry. The associations among DKK1 level, beta-catenin accumulation, clinicopathological factors and the overall survival were separately evaluated.

Results: Both DKK1 and beta-catenin levels were remarkably elevated in chondrosarcoma compared with the corresponding non-tumor tissues. High DKK1 level and positive beta-catenin accumulation in chondrosarcoma specimens were 58.7% and 53.9%, respectively. Elevated DKK1 level significantly correlated with positive beta-catenin accumulation, and they were remarkably associated with histological grade and Musculoskeletal Tumor Society stage. Furthermore, DKK1 level and bcatenin accumulation had significant impacts on the prognosis of chondrosarcoma patients. Multivariate analysis revealed that DKK1 level was an independent prognostic factor for overall survival.

Conclusions: Elevated DKK1 levels associated with beta-catenin accumulation play a crucial role in chondrosarcoma. DKK1 can serve as a novel predictor of poor prognosis in patients with chondrosarcoma.

语种: 英语
所属项目编号: 81102037
项目资助者: National Natural Sciences Foundation of China
WOS记录号: WOS:000341106100065
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63380
Appears in Collections:北京大学第三临床医学院_骨科_期刊论文

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作者单位: 1.Tianjin Hosp, Dept Spinal Surg, Tianjin, Peoples R China
2.Peking Univ, Dept Orthopaed Surg, Hosp 3, Beijing 100871, Peoples R China

Recommended Citation:
Chen, Changbao,Zhou, Hua,Zhang, Xiaolin,et al. Elevated Levels of Dickkopf-1 Are Associated with beta-Catenin Accumulation and Poor Prognosis in Patients with Chondrosarcoma[J]. PLOS ONE,2014,9(8).
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