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学科主题: 基础医学
题名:
Solvothermal Synthesis, Crystal Structure of a 1D Coordination Polymer [Er(CCA)(3)(H2O)(2)](n)center dot 2nH(2)O (HCCA=Coumarin-3-Carboxylic Acid) and the Interaction between the Polymer and Bovine Serum Albumin (BSA)
作者: Yang Shuping1; Han Lijun2; Wang Daqi3; Pan Yan4,5; Yu Zhiqun1; Ye Haiyan1
关键词: erbium(III) coordination polymer ; coumarin-3-carboxylic acid ; crystal structure ; bovine serum albumin (BSA) ; fluorescence spectra ; solvent-thermal method
刊名: ACTA CHIMICA SINICA
发表日期: 2011-10-14
卷: 69, 期:19, 页:2319-2327
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Multidisciplinary
研究领域[WOS]: Chemistry
关键词[WOS]: COUMARIN-3-CARBOXYLIC ACID ; COPPER(II) COMPLEX ; ANTINEOPLASTIC ACTIVITY ; LANTHANIDE COMPLEXES ; ENERGY-TRANSFER ; DERIVATIVES ; FLUORESCENCE ; LIGAND ; CYTOTOXICITY ; INHIBITORS
英文摘要:

A coordination polymer [Er(CCA)(3)(H2O)(2)](n)center dot 2(n)H(2)O (HCCA=coumarin-3-carboxylic acid) has been prepared by solvent-thermal method and characterized by elemental analysis and IR spectra and single crystal X-ray diffraction. The crystal of erbium(III) complex belongs to monoclinic system with space group, P2(1)/c, a=0.6310(1) nm, b=1.4165(2) nm, c=3.1731(3) nm; beta=91.861(2)degrees, V=2.8346(7) nm(3), D-c=1.890 g.cm(-3), Z=4, F(000)=1596, residual factors R-1=0.0525, wR(2)=0.0930 [l>2 sigma(l)], S=1.290. The Er(III) atom is eight-coordinated by eight O atoms from three ligands (CCA) and two coordinated water molecules, and the coordination polyhedron around the Er(III) atom can be best described as a distorted dodecahedron geometry. Two adjacent Er(III) atoms were bridged into a one-dimensional polymeric chain by the carboxylic group in a ligand (CCA). The interaction between complex and bovine serum albumin (BSA) was investigated by fluorescence spectroscopy at different temperature. The results indicated that the complex quenches the fluorescence of BSA through a static quenching procedure. The binding constants (K-a) and the number of binding sites (n) between the complex and BSA were calculated at different temperature. The corresponding thermodynamic parameters enthalpy changes (Iota H>0) and entropy changes (Delta S>0) were also obtained according to the van′t Hoff equation. The primary binding pattern between complex and BSA was interpreted as hydrophobic interaction. The binding average distance r between the donor (BSA) and acceptor (complex) was obtained to be 2.85 nm based on the Foster′s theory, which indicates the non-radiation energy transfer can occur from BSA to complex with high probability.

语种: 中文
WOS记录号: WOS:000296933700019
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63383
Appears in Collections:基础医学院_北京大学系统生物医学研究所_期刊论文

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Solvothermal Synthesis%2C Crystal Structure of a 1D Coordination Polymer %5BEr%28CCA%293%28H2O%292%5Dn%26bull%3B2nH2O %28HCCA=Coumarin-3-Carboxylic Acid%29 and the Interaction between the Polymer and Bovine Serum Albumin %28BS.pdf(981KB)期刊论文作者接受稿限制开放 联系获取全文

作者单位: 1.Huaihai Inst Technol, Sch Chem Engn, Lianyungang 222005, Peoples R China
2.Peking Univ, Inst Syst Biomed, Beijing 100191, Peoples R China
3.Huaihai Inst Technol, Sch Math & Sci, Lianyungang 222005, Peoples R China
4.Liaocheng Univ, Sch Chem & Chem Engn, Liaocheng 252059, Peoples R China
5.Peking Univ, Sch Basic Med Sci, Dept Pharmacol, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China

Recommended Citation:
Yang Shuping,Han Lijun,Wang Daqi,et al. Solvothermal Synthesis, Crystal Structure of a 1D Coordination Polymer [Er(CCA)(3)(H2O)(2)](n)center dot 2nH(2)O (HCCA=Coumarin-3-Carboxylic Acid) and the Interaction between the Polymer and Bovine Serum Albumin (BSA)[J]. ACTA CHIMICA SINICA,2011,69(19):2319-2327.
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