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学科主题: 基础医学
题名:
The Paradox of Dopamine and Angiotensin II-Mediated Na+, K+-ATPase Regulation in Renal Proximal Tubules
作者: Zhang, Linan2; Guo, Fang1; Guo, Huicai3; Wang, Haiyan4; Zhang, Zhe5; Liu, Xu6; Shi, Xiaolu7; Gou, Xiangbo; Su, Qian8; Yin, Jian1; Wang, Yongli1
关键词: Na+,K+-ATPase ; dopamine ; angiotensin II ; renal proximal tubule ; protein kinase C ; adenylyl cyclase
刊名: CLINICAL AND EXPERIMENTAL HYPERTENSION
发表日期: 2010
DOI: 10.3109/10641963.2010.496516
卷: 32, 期:7, 页:464-468
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy ; Peripheral Vascular Disease
研究领域[WOS]: Pharmacology & Pharmacy ; Cardiovascular System & Cardiology
关键词[WOS]: NA+,K+-ATPASE ALPHA-SUBUNIT ; PROTEIN-KINASE-C ; ATRIAL-NATRIURETIC-FACTOR ; PLASMA-MEMBRANE ; EPITHELIAL-CELLS ; INTRARENAL DOPAMINE ; HYPERTENSIVE-RATS ; BLOOD-PRESSURE ; H+ EXCHANGER ; SODIUM-PUMP
英文摘要:

Accumulated studies reported that the natruretic dopamine (DA) and the anti-natruretic angiotensin II (Ang II) represent an important mechanism to regulate renal Na+ and water excretion through intracellular secondary messengers to inhibit or activate renal proximal tubule (PT) Na+,K+-ATPase (NKA). The antagonistic actions were mediated by the phosphorylation of different position of NKA alpha(1)-subunit and different Pals-associated tight junction protein (PATJ) PDZ domains, the different protein kinase C (PKC) isoforms (PKC-beta, PKC-zeta), the common adenylyl cyclase (AC) pathway, and the crosstalk and balance between DA and Ang II to NKA regulation. Besides, Ang II-mediated NKA modulation has bi-phasic effects.

语种: 英语
WOS记录号: WOS:000283593500010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63384
Appears in Collections:基础医学院_期刊论文

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作者单位: 1.Peking Univ, Sch Basic Med Sci, Beijing, Hebei, Peoples R China
2.Peking Univ, Inst Mol Med, Beijing 100871, Peoples R China
3.Hebei Med Univ, Dept Pharmacol, Shijiazhuang 050017, Hebei, Peoples R China
4.Hebei Univ Sci & Technol, Dept Pharm, Shijiazhuang, Hebei, Peoples R China
5.Hebei Med Univ, Sch Publ Hlth, Shijiazhuang 050017, Hebei, Peoples R China
6.Shijiazhuang Municipal 3 Hosp, Pharmaceut Preparat Sect, Shijiazhuang, Hebei, Peoples R China
7.Peoples Hosp Hebei Prov, Clin Trial Ctr, Shijiazhuang, Hebei, Peoples R China
8.Chinese Acad Sci, SIBS, Inst Nutr Sci, Shanghai, Peoples R China

Recommended Citation:
Zhang, Linan,Guo, Fang,Guo, Huicai,et al. The Paradox of Dopamine and Angiotensin II-Mediated Na+, K+-ATPase Regulation in Renal Proximal Tubules[J]. CLINICAL AND EXPERIMENTAL HYPERTENSION,2010,32(7):464-468.
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