学科主题基础医学
Pulsed amperometric detection with poly(dimethylsiloxane)-fabricated capillary electrophoresis microchips for the determination of EPA priority pollutants
Ding, YS; Garcia, CD
刊名ANALYST
2006
DOI10.1039/b509405d
131期:2页:208-214
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Analytical
研究领域[WOS]Chemistry
关键词[WOS]SOLID-PHASE MICROEXTRACTION ; GLASSY-CARBON ELECTRODES ; PERFORMANCE LIQUID-CHROMATOGRAPHY ; FLOW-INJECTION ANALYSIS ; POTENTIAL WAVE-FORM ; ON-A-CHIP ; ELECTROCHEMICAL DETECTION ; PHENOLIC-COMPOUNDS ; MASS-SPECTROMETRY ; MICROFLUIDIC SYSTEMS
英文摘要

A miniaturized analytical system for separation and detection of three EPA priority phenolic pollutants, based on a poly(dimethylsiloxane)-fabricated capillary electrophoresis microchip and pulsed amperometric detection is described. The approach offers a rapid (less than 2 min), simultaneous measurement of three phenolic pollutants: phenol, 4,6-dinitro-o-cresol and pentachlorophenol. The highly stable response (RSD = 6.1%) observed for repetitive injections (n > 100) reflects the effectiveness of Au working electrode cleaned by pulsed amperometric detection. The effect of solution conditions, separation potential and detection waveform were optimized for both the separation and detection of phenols. Under the optimum conditions (5.0 mM phosphate buffer pH 5 12.4, detection potential: 0.7 V, separation potential: 1200 V, injection time: 10 s) the baseline separation of the three selected compounds was achieved. Limits of detection of 2.2 mu M (2.8 fmol), 0.9 mu M (1.1 fmol), and 1.3 mu M (1.6 fmol) were achieved for phenol, 4,6-dinitro-o-cresol and pentachlorophenol, respectively. A local city water sample and two over-the-counter sore-throat medicines were analyzed in order to demonstrate the capabilities of the proposed technique to face real applications.

语种英语
WOS记录号WOS:000235988500005
引用统计
被引频次:38[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63385
专题北京大学基础医学院_生物化学与分子生物学系
作者单位1.Univ Texas, Dept Chem, San Antonio, TX 78249 USA
2.Peking Univ, Hlth Sci Ctr, Dept Biol Chem, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Ding, YS,Garcia, CD. Pulsed amperometric detection with poly(dimethylsiloxane)-fabricated capillary electrophoresis microchips for the determination of EPA priority pollutants[J]. ANALYST,2006,131(2):208-214.
APA Ding, YS,&Garcia, CD.(2006).Pulsed amperometric detection with poly(dimethylsiloxane)-fabricated capillary electrophoresis microchips for the determination of EPA priority pollutants.ANALYST,131(2),208-214.
MLA Ding, YS,et al."Pulsed amperometric detection with poly(dimethylsiloxane)-fabricated capillary electrophoresis microchips for the determination of EPA priority pollutants".ANALYST 131.2(2006):208-214.
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