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学科主题: 基础医学
题名:
Pulsed amperometric detection with poly(dimethylsiloxane)-fabricated capillary electrophoresis microchips for the determination of EPA priority pollutants
作者: Ding, YS; Garcia, CD
刊名: ANALYST
发表日期: 2006
DOI: 10.1039/b509405d
卷: 131, 期:2, 页:208-214
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Analytical
研究领域[WOS]: Chemistry
关键词[WOS]: SOLID-PHASE MICROEXTRACTION ; GLASSY-CARBON ELECTRODES ; PERFORMANCE LIQUID-CHROMATOGRAPHY ; FLOW-INJECTION ANALYSIS ; POTENTIAL WAVE-FORM ; ON-A-CHIP ; ELECTROCHEMICAL DETECTION ; PHENOLIC-COMPOUNDS ; MASS-SPECTROMETRY ; MICROFLUIDIC SYSTEMS
英文摘要:

A miniaturized analytical system for separation and detection of three EPA priority phenolic pollutants, based on a poly(dimethylsiloxane)-fabricated capillary electrophoresis microchip and pulsed amperometric detection is described. The approach offers a rapid (less than 2 min), simultaneous measurement of three phenolic pollutants: phenol, 4,6-dinitro-o-cresol and pentachlorophenol. The highly stable response (RSD = 6.1%) observed for repetitive injections (n > 100) reflects the effectiveness of Au working electrode cleaned by pulsed amperometric detection. The effect of solution conditions, separation potential and detection waveform were optimized for both the separation and detection of phenols. Under the optimum conditions (5.0 mM phosphate buffer pH 5 12.4, detection potential: 0.7 V, separation potential: 1200 V, injection time: 10 s) the baseline separation of the three selected compounds was achieved. Limits of detection of 2.2 mu M (2.8 fmol), 0.9 mu M (1.1 fmol), and 1.3 mu M (1.6 fmol) were achieved for phenol, 4,6-dinitro-o-cresol and pentachlorophenol, respectively. A local city water sample and two over-the-counter sore-throat medicines were analyzed in order to demonstrate the capabilities of the proposed technique to face real applications.

语种: 英语
WOS记录号: WOS:000235988500005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63385
Appears in Collections:基础医学院_生物化学与分子生物学系_期刊论文

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作者单位: 1.Univ Texas, Dept Chem, San Antonio, TX 78249 USA
2.Peking Univ, Hlth Sci Ctr, Dept Biol Chem, Beijing 100083, Peoples R China

Recommended Citation:
Ding, YS,Garcia, CD. Pulsed amperometric detection with poly(dimethylsiloxane)-fabricated capillary electrophoresis microchips for the determination of EPA priority pollutants[J]. ANALYST,2006,131(2):208-214.
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