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学科主题: 药学
题名:
Prolonged hypoglycemic effect of insulin-loaded polybutylcyanoacrylate nanoparticles after pulmonary administration to normal rats
作者: Zhang, Q; Shen, ZC; Nagai, T
关键词: insulin ; nanoparticles ; hypoglycemic effect ; rats ; pulmonary administration polybutylcyanoacrylate
刊名: INTERNATIONAL JOURNAL OF PHARMACEUTICS
发表日期: 2001-05-07
卷: 218, 期:1-2, 页:75-80
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: DELIVERY ; ABSORPTION ; INTRATRACHEAL ; PARTICLES ; AEROSOL ; LUNG
英文摘要:

Insulin-loaded polybutylcyanoacrylate nanoparticles were prepared by emulsion polymerization. The mean diameter of the nanoparticles was 254.7 nm with a polydispersity of 0.064. The associating ratio of insulin to the nanoparticles reached 79.1%. Studies on in vitro release kinetics showed that release profiles can be modeled using a biexponential function and the burst effect was obvious. After various doses of insulin-loaded nanoparticles were intratracheally given to normal rats, significant decrease of glucose level was achieved at each dose group from 5 to 20 IU kg(-1). The minimum blood glucose concentration reached 46.9%, 30.1% and 13.6% of the initial level after pulmonary delivery of 5, 10 and 20 IU kg(-1) insulin-loaded nanoparticles to normal rats, respectively. The time to reach the minimum blood glucose level (T-min) was it 4. 4 and 8 h for three doses, respectively. The duration of glucose level below 80%, of insulin-loaded nanoparticles was much longer than that of insulin solution at every dose. Relative pharmacological bioavailability of insulin-loaded nanoparticles by pulmonary administration was 57.2% over the same formulation by subcutaneous administration. (C) 2001 Elsevier Science B.V.

语种: 英语
WOS记录号: WOS:000168739000007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63392
Appears in Collections:北京大学药学院_药剂学系_期刊论文

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作者单位: 1.Hoshi Univ, Dept Pharmaceut, Shinagawa Ku, Tokyo 1428501, Japan
2.Peking Univ, Sch Pharmaceut Sci, Dept Pharmaceut, Beijing 100083, Peoples R China

Recommended Citation:
Zhang, Q,Shen, ZC,Nagai, T. Prolonged hypoglycemic effect of insulin-loaded polybutylcyanoacrylate nanoparticles after pulmonary administration to normal rats[J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS,2001,218(1-2):75-80.
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