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学科主题基础医学
Triptolide upregulates NGF synthesis in rat astrocyte cultures
Xue, Bing; Jiao, Jian; Zhang, Lei; Li, Kai-Rong; Gong, Yun-Tao; Xie, Jun-Xia; Wang, Xiao-Min
关键词Nerve Growth Factor Brain-derived Neurotrophic Factor Glial Cell Line-derived Neurotrophic Factor Triptolide Center Dot Astrocyte
刊名NEUROCHEMICAL RESEARCH
2007-07-01
DOI10.1007/s11064-006-9253-1
32期:7页:1113-1119
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Neurosciences
研究领域[WOS]Biochemistry & Molecular Biology ; Neurosciences & Neurology
关键词[WOS]NERVE GROWTH-FACTOR ; CHOLINERGIC NEURONAL DEGENERATION ; NEUROTROPHIC FACTOR ; MESSENGER-RNA ; DOPAMINERGIC-NEURONS ; FACTOR SECRETION ; PRIMATE BRAIN ; CELLS ; EXPRESSION ; DAMAGE
英文摘要

Triptolide (T10), an extract from the traditional Chinese herb, Tripterygium wilfordii Hook F (TWHF), has been shown to attenuate the rotational behavior induced by d-amphetamine and prevent the loss of dopaminergic neurons in the substantia nigra in rat models of Parkinson′s disease. To examine if the neuroprotective effect is mediated by its stimulation of production of neurotrophic factors from astrocytes, we investigated the effect of T10 on synthesis and release of nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF) and glial cell line-derived neurotrophic factor (GDNF) in rat astrocyte cultures. T10 did not affect the synthesis and release of either BDNF or GDNF. However, it significantly increased NGF mRNA expression. It also increased both intracellular NGF and NGF level in culture medium. These results indicate that the neuroprotective effect of T10 might be mediated, at least in part, via a stimulation of the production and release of NGF in astrocytes.

语种英语
WOS记录号WOS:000246768100002
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被引频次:29[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
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条目标识符http://ir.bjmu.edu.cn/handle/400002259/63397
专题北京大学基础医学院_神经生物学系
作者单位1.Peking Univ, Hlth Sci Ctr, Dept Neurobiol, Neurosci Res Inst,Key Lab Neurosci,Minist Educ, Beijing 100083, Peoples R China
2.Capital Med Univ, Key Lab Neurodegenerat Disorders, Beijing Inst Neurosci, Minist Educ, Beijing 100069, Peoples R China
3.Qingdao Univ, Coll Med, Dept Physiol, Qingdao 266021, Peoples R China
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GB/T 7714
Xue, Bing,Jiao, Jian,Zhang, Lei,et al. Triptolide upregulates NGF synthesis in rat astrocyte cultures[J]. NEUROCHEMICAL RESEARCH,2007,32(7):1113-1119.
APA Xue, Bing.,Jiao, Jian.,Zhang, Lei.,Li, Kai-Rong.,Gong, Yun-Tao.,...&Wang, Xiao-Min.(2007).Triptolide upregulates NGF synthesis in rat astrocyte cultures.NEUROCHEMICAL RESEARCH,32(7),1113-1119.
MLA Xue, Bing,et al."Triptolide upregulates NGF synthesis in rat astrocyte cultures".NEUROCHEMICAL RESEARCH 32.7(2007):1113-1119.
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