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学科主题: 基础医学
题名:
Triptolide upregulates NGF synthesis in rat astrocyte cultures
作者: Xue, Bing; Jiao, Jian; Zhang, Lei; Li, Kai-Rong; Gong, Yun-Tao; Xie, Jun-Xia; Wang, Xiao-Min
关键词: nerve growth factor ; brain-derived neurotrophic factor ; glial cell line-derived neurotrophic factor ; triptolide center dot astrocyte
刊名: NEUROCHEMICAL RESEARCH
发表日期: 2007-07-01
DOI: 10.1007/s11064-006-9253-1
卷: 32, 期:7, 页:1113-1119
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Neurosciences
研究领域[WOS]: Biochemistry & Molecular Biology ; Neurosciences & Neurology
关键词[WOS]: NERVE GROWTH-FACTOR ; CHOLINERGIC NEURONAL DEGENERATION ; NEUROTROPHIC FACTOR ; MESSENGER-RNA ; DOPAMINERGIC-NEURONS ; FACTOR SECRETION ; PRIMATE BRAIN ; CELLS ; EXPRESSION ; DAMAGE
英文摘要:

Triptolide (T10), an extract from the traditional Chinese herb, Tripterygium wilfordii Hook F (TWHF), has been shown to attenuate the rotational behavior induced by d-amphetamine and prevent the loss of dopaminergic neurons in the substantia nigra in rat models of Parkinson′s disease. To examine if the neuroprotective effect is mediated by its stimulation of production of neurotrophic factors from astrocytes, we investigated the effect of T10 on synthesis and release of nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF) and glial cell line-derived neurotrophic factor (GDNF) in rat astrocyte cultures. T10 did not affect the synthesis and release of either BDNF or GDNF. However, it significantly increased NGF mRNA expression. It also increased both intracellular NGF and NGF level in culture medium. These results indicate that the neuroprotective effect of T10 might be mediated, at least in part, via a stimulation of the production and release of NGF in astrocytes.

语种: 英语
WOS记录号: WOS:000246768100002
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63397
Appears in Collections:基础医学院_神经生物学系_期刊论文

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作者单位: 1.Peking Univ, Hlth Sci Ctr, Dept Neurobiol, Neurosci Res Inst,Key Lab Neurosci,Minist Educ, Beijing 100083, Peoples R China
2.Capital Med Univ, Key Lab Neurodegenerat Disorders, Beijing Inst Neurosci, Minist Educ, Beijing 100069, Peoples R China
3.Qingdao Univ, Coll Med, Dept Physiol, Qingdao 266021, Peoples R China

Recommended Citation:
Xue, Bing,Jiao, Jian,Zhang, Lei,et al. Triptolide upregulates NGF synthesis in rat astrocyte cultures[J]. NEUROCHEMICAL RESEARCH,2007,32(7):1113-1119.
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