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An end-to-end anastomosis model of guinea pig bile duct: A 6-mo observation
Zhang, Xiao-Qing; Tian, Yuan-Hu; Xu, Zhi; Wang, Li-Xin; Hou, Chun-Sheng; Ling, Xiao-Feng; Zhou, Xiao-Si
关键词Animal model Guinea pig Anastomosis Common bile duct Wound healing
刊名WORLD JOURNAL OF GASTROENTEROLOGY
2011-02-14
DOI10.3748/wjg.v17.i6.789
17期:6页:789-795
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Gastroenterology & Hepatology
研究领域[WOS]Gastroenterology & Hepatology
关键词[WOS]DONOR LIVER-TRANSPLANTATION ; GASTRIC-ACID SECRETION ; BILIARY RECONSTRUCTION ; PIGMENT GALLSTONES ; CYCLIN PCNA ; HEPATICOJEJUNOSTOMY ; MANAGEMENT ; STRICTURES ; INJURIES
英文摘要

AIM: To establish the end-to-end anastomosis (EEA) model of guinea pig bile duct and evaluate the healing process of bile duct.

METHODS: Thirty-two male guinea pigs were randomly divided into control group, 2-, 3-, and 6-mo groups after establishment of EEA model. Histological, immunohistochemical and serologic tests as well as measurement of bile contents were performed. The bile duct diameter and the diameter ratio (DR) were measured to assess the formation of relative stricture.

RESULTS: Acute and chronic inflammatory reactions occurred throughout the healing process of bile duct. Serology test and bile content measurement showed no formation of persistent stricture in 6-mo group. The DR revealed a transient formation of relative stricture in 2-mo group in comparation to control group (2.94 +/- 0.17 vs 1.89 +/- 0.27, P = 0.004). However, this relative stricture was released in 6-mo group (2.14 +/- 0.18, P = 0.440).

CONCLUSION: A simple and reliable EEA model of guinea pig bile duct can be established with a good reproducibility and a satisfactory survival rate. (C) 2011 Baishideng. All rights reserved.

语种英语
WOS记录号WOS:000288058700015
项目编号2007AA04Z313
资助机构National 863 Program of China
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63402
专题北京大学第三临床医学院_普通外科
北京大学第三临床医学院_麻醉科
作者单位Peking Univ, Hosp 3, Dept Gen Surg, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Zhang, Xiao-Qing,Tian, Yuan-Hu,Xu, Zhi,et al. An end-to-end anastomosis model of guinea pig bile duct: A 6-mo observation[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2011,17(6):789-795.
APA Zhang, Xiao-Qing.,Tian, Yuan-Hu.,Xu, Zhi.,Wang, Li-Xin.,Hou, Chun-Sheng.,...&Zhou, Xiao-Si.(2011).An end-to-end anastomosis model of guinea pig bile duct: A 6-mo observation.WORLD JOURNAL OF GASTROENTEROLOGY,17(6),789-795.
MLA Zhang, Xiao-Qing,et al."An end-to-end anastomosis model of guinea pig bile duct: A 6-mo observation".WORLD JOURNAL OF GASTROENTEROLOGY 17.6(2011):789-795.
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