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学科主题: 临床医学
题名:
An end-to-end anastomosis model of guinea pig bile duct: A 6-mo observation
作者: Zhang, Xiao-Qing; Tian, Yuan-Hu; Xu, Zhi; Wang, Li-Xin; Hou, Chun-Sheng; Ling, Xiao-Feng; Zhou, Xiao-Si
关键词: Animal model ; Guinea pig ; Anastomosis ; Common bile duct ; Wound healing
刊名: WORLD JOURNAL OF GASTROENTEROLOGY
发表日期: 2011-02-14
DOI: 10.3748/wjg.v17.i6.789
卷: 17, 期:6, 页:789-795
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Gastroenterology & Hepatology
研究领域[WOS]: Gastroenterology & Hepatology
关键词[WOS]: DONOR LIVER-TRANSPLANTATION ; GASTRIC-ACID SECRETION ; BILIARY RECONSTRUCTION ; PIGMENT GALLSTONES ; CYCLIN PCNA ; HEPATICOJEJUNOSTOMY ; MANAGEMENT ; STRICTURES ; INJURIES
英文摘要:

AIM: To establish the end-to-end anastomosis (EEA) model of guinea pig bile duct and evaluate the healing process of bile duct.

METHODS: Thirty-two male guinea pigs were randomly divided into control group, 2-, 3-, and 6-mo groups after establishment of EEA model. Histological, immunohistochemical and serologic tests as well as measurement of bile contents were performed. The bile duct diameter and the diameter ratio (DR) were measured to assess the formation of relative stricture.

RESULTS: Acute and chronic inflammatory reactions occurred throughout the healing process of bile duct. Serology test and bile content measurement showed no formation of persistent stricture in 6-mo group. The DR revealed a transient formation of relative stricture in 2-mo group in comparation to control group (2.94 +/- 0.17 vs 1.89 +/- 0.27, P = 0.004). However, this relative stricture was released in 6-mo group (2.14 +/- 0.18, P = 0.440).

CONCLUSION: A simple and reliable EEA model of guinea pig bile duct can be established with a good reproducibility and a satisfactory survival rate. (C) 2011 Baishideng. All rights reserved.

语种: 英语
所属项目编号: 2007AA04Z313
项目资助者: National 863 Program of China
WOS记录号: WOS:000288058700015
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63402
Appears in Collections:北京大学第三临床医学院_普通外科_期刊论文

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作者单位: Peking Univ, Hosp 3, Dept Gen Surg, Beijing 100191, Peoples R China

Recommended Citation:
Zhang, Xiao-Qing,Tian, Yuan-Hu,Xu, Zhi,et al. An end-to-end anastomosis model of guinea pig bile duct: A 6-mo observation[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2011,17(6):789-795.
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