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学科主题: 口腔医学
题名:
Guided bone regeneration with tripolyphosphate cross-linked asymmetric chitosan membrane
作者: Ma, Shiqing1; Chen, Zhen1; Qiao, Feng1; Sun, Yingchun1; Yang, Xiaoping2; Deng, Xuliang3; Cen, Lian4,5; Cai, Qing2; Wu, Mingyao1; Zhang, Xu1; Gao, Ping1
关键词: Guided bone regeneration ; Asymmetric ; Chitosan membrane ; Sodium tripolyphosphate
刊名: JOURNAL OF DENTISTRY
发表日期: 2014-12-01
DOI: 10.1016/j.jdent.2014.08.015
卷: 42, 期:12, 页:1603-1612
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Dentistry, Oral Surgery & Medicine
研究领域[WOS]: Dentistry, Oral Surgery & Medicine
关键词[WOS]: PERIODONTAL TISSUE REGENERATION ; IN-VITRO ; ANTIBACTERIAL ACTIVITY ; SCAFFOLDS ; LINKING ; RELEASE ; PH ; NANOPARTICLES ; KINETICS ; DELIVERY
英文摘要:

Objectives: The objective of this study was to prepare a novel asymmetric chitosan guided bone regeneration (GBR) membrane, which is composed of a dense layer isolating the bone defect from the invasion of surrounding connective fibrous tissue and a loose layer which can improve cell adhesion and stabilize blood clots, thus guided bone regeneration.

Methods: The chitosan membrane was fabricated through liquid nitrogen quencher combined with lyophilization and cross-linked by sodium tripolyphosphate (TPP). The physical properties of asymmetric chitosan membrane were measured by scanning electron microscope (SEM), Fourier-transform infrared (FTIR), x-ray diffraction (XRD) and tensile test machine. MTT assay and Live/Dead cell staining for MC3T3-E1 osteoblasts cultured on the membrane were used to characterize the biocompatibility of the membrane. In animal experiments, full-thickness and critical sized skull defects were made to evaluate the effect of the membrane on bone regeneration.

Results: The results of this study indicate that the asymmetric chitosan membrane can be built and cross-linked by TPP to enhance the tensile strength of the membrane. In vitro experiment showed that no significant numbers of dead cells were detected on the chitosan membrane, indicating that the membrane had good biocompatibility. In animal experiments, the chitosan membrane had faster new bone formation, showing the capability to enhance bone regeneration. Conclusions: The chitosan membrane prepared in this study has an asymmetric structure; its tensile strength, biodegradation and biocompatibility fulfil the requirements of guided bone regeneration. Therefore, the asymmetric chitosan membrane is a promising GBR membrane for bone regeneration.

Clinical significance: Guided bone regeneration (GBR) is an effective method for healing bone defects caused by periodontitis and implantitis, in which GBR membrane is a key biomaterial. (C) 2014 Elsevier Ltd. All rights reserved.

语种: 英语
所属项目编号: 2012BAI07B00 ; 14JCYBJC29600 ; 2010CB944804 ; 201310062005
项目资助者: National Science and Technology Support Project Foundation ; Tianjin Research Program of Application Foundation and Advanced Technology ; National "973&prime ; &prime ; Project Foundation ; National Training Programs of Innovation and Entrepreneurship for Undergraduates
WOS记录号: WOS:000345512200011
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63411
Appears in Collections:北京大学口腔医学院_期刊论文

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作者单位: 1.Natl Tissue Engn Ctr China, Shanghai 200241, Peoples R China
2.Tianjin Med Univ, Sch & Hosp Stomatol, Tianjin 300070, Peoples R China
3.Beijing Univ Chem Technol, Key Lab Beijing City Preparat & Proc Novel Polyme, Beijing 100029, Peoples R China
4.Peking Univ, Sch & Hosp Stomatol, Dept Geriatr Dent, Beijing 100081, Peoples R China
5.E China Univ Sci & Technol, Sch Chem Engn, Shanghai 200237, Peoples R China

Recommended Citation:
Ma, Shiqing,Chen, Zhen,Qiao, Feng,et al. Guided bone regeneration with tripolyphosphate cross-linked asymmetric chitosan membrane[J]. JOURNAL OF DENTISTRY,2014,42(12):1603-1612.
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