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学科主题: 临床医学
题名:
Impact of Yangzheng Xiaoji on the Adhesion and Migration of Human Cancer Cells: the Role of the AKT Signalling Pathway
作者: Ye, Lin1,2; Ji, Ke1,2; Frewer, Natasha1; Ji, Jiafu2,3; Jiang, Wen G.1,2
关键词: Cancer cells ; cellular migration ; cell adhesion ; prostate cancer ; osteosarcoma ; signal transduction pathways ; ECIS ; AKT ; PI3K
刊名: ANTICANCER RESEARCH
发表日期: 2012-07-01
卷: 32, 期:7, 页:2537-2543
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: VASCULAR ENDOTHELIAL-CELLS ; IN-VITRO ; GROWTH ; ARTEMISININ ; ANGIOGENESIS ; DERIVATIVES ; ACID
英文摘要:

Background: Yangzheng Xiaoji is a traditional Chinese medical formulation that has been shown to have anticancer actions in patients with various solid tumours. The mechanisms of the potential anticancer action of Yangzheng Xiaoji are unknown. In the present study, we investigated the direct effects of Yangzheng Xiaoji on a range of human cancer cell lines and investigated the possible mechanism(s) of its action. Materials and Methods: Extract of Yangzheng Xiaoji (DME25) was prepared using dimethyl sulfoxide. The influence of DME25 on in vitro growth, adhesion and migration was examined using in vitro function assays. The effects on signalling protein kinases were assessed using western blotting. Results: DME25 suppressed adhesion and migration of various cancer cell, including those of breast, prostate, lung, osteosarcoma and colorectal cancer. Further investigation showed an involvement of the phosphatidylinositol 3-kinases/protein kinase B (PI3K/AKT) pathway in the inhibitory effect on the adhesion of cancer cells by DME25. Conclusion: Yangzheng Xiaoji exerts its anticancer effects not only via synergistically working together with chemotherapy, but also by directly inhibiting adhesion and migration of cancer cells. The PI3K/AKT pathway is a potential signalling pathway targeted by Yangzheng Xiaoji.

语种: 英语
项目资助者: Albert Hung Foundation ; Cancer Research Wales
WOS记录号: WOS:000306254300017
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63413
Appears in Collections:北京大学临床肿瘤学院_期刊论文

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作者单位: 1.Cardiff Univ Peking Univ Sch Oncol Joint Inst, Cardiff, S Glam, Wales
2.Cardiff Univ, Sch Med, Metastasis & Angiogenesis Res Grp, Cardiff CF14 4XN, S Glam, Wales
3.Peking Univ, Canc Hosp, Dept Gastroenterol Oncol, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100871, Peoples R China

Recommended Citation:
Ye, Lin,Ji, Ke,Frewer, Natasha,et al. Impact of Yangzheng Xiaoji on the Adhesion and Migration of Human Cancer Cells: the Role of the AKT Signalling Pathway[J]. ANTICANCER RESEARCH,2012,32(7):2537-2543.
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