IR@PKUHSC  > 北京大学临床肿瘤学院
学科主题临床医学
Impact of Yangzheng Xiaoji on the Adhesion and Migration of Human Cancer Cells: the Role of the AKT Signalling Pathway
Ye, Lin1,2; Ji, Ke1,2; Frewer, Natasha1; Ji, Jiafu2,3; Jiang, Wen G.1,2
关键词Cancer cells cellular migration cell adhesion prostate cancer osteosarcoma signal transduction pathways ECIS AKT PI3K
刊名ANTICANCER RESEARCH
2012-07-01
32期:7页:2537-2543
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]VASCULAR ENDOTHELIAL-CELLS ; IN-VITRO ; GROWTH ; ARTEMISININ ; ANGIOGENESIS ; DERIVATIVES ; ACID
英文摘要

Background: Yangzheng Xiaoji is a traditional Chinese medical formulation that has been shown to have anticancer actions in patients with various solid tumours. The mechanisms of the potential anticancer action of Yangzheng Xiaoji are unknown. In the present study, we investigated the direct effects of Yangzheng Xiaoji on a range of human cancer cell lines and investigated the possible mechanism(s) of its action. Materials and Methods: Extract of Yangzheng Xiaoji (DME25) was prepared using dimethyl sulfoxide. The influence of DME25 on in vitro growth, adhesion and migration was examined using in vitro function assays. The effects on signalling protein kinases were assessed using western blotting. Results: DME25 suppressed adhesion and migration of various cancer cell, including those of breast, prostate, lung, osteosarcoma and colorectal cancer. Further investigation showed an involvement of the phosphatidylinositol 3-kinases/protein kinase B (PI3K/AKT) pathway in the inhibitory effect on the adhesion of cancer cells by DME25. Conclusion: Yangzheng Xiaoji exerts its anticancer effects not only via synergistically working together with chemotherapy, but also by directly inhibiting adhesion and migration of cancer cells. The PI3K/AKT pathway is a potential signalling pathway targeted by Yangzheng Xiaoji.

语种英语
WOS记录号WOS:000306254300017
资助机构Albert Hung Foundation ; Cancer Research Wales
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63413
专题北京大学临床肿瘤学院
北京大学临床肿瘤学院_胃肠肿瘤中心一病区
作者单位1.Cardiff Univ Peking Univ Sch Oncol Joint Inst, Cardiff, S Glam, Wales
2.Cardiff Univ, Sch Med, Metastasis & Angiogenesis Res Grp, Cardiff CF14 4XN, S Glam, Wales
3.Peking Univ, Canc Hosp, Dept Gastroenterol Oncol, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100871, Peoples R China
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GB/T 7714
Ye, Lin,Ji, Ke,Frewer, Natasha,et al. Impact of Yangzheng Xiaoji on the Adhesion and Migration of Human Cancer Cells: the Role of the AKT Signalling Pathway[J]. ANTICANCER RESEARCH,2012,32(7):2537-2543.
APA Ye, Lin,Ji, Ke,Frewer, Natasha,Ji, Jiafu,&Jiang, Wen G..(2012).Impact of Yangzheng Xiaoji on the Adhesion and Migration of Human Cancer Cells: the Role of the AKT Signalling Pathway.ANTICANCER RESEARCH,32(7),2537-2543.
MLA Ye, Lin,et al."Impact of Yangzheng Xiaoji on the Adhesion and Migration of Human Cancer Cells: the Role of the AKT Signalling Pathway".ANTICANCER RESEARCH 32.7(2012):2537-2543.
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