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学科主题: 临床医学
题名:
Induction of C-Mip by IL-17 Plays an Important Role in Adriamycin-Induced Podocyte Damage
作者: Liu, Yanbo1; Su, Lin2; Lin, Qiuxia3,4; Han, Ying5; You, Peng2; Fan, Qingfeng5
关键词: Adriamycin ; Podocyte ; Treg cell ; Th17 cell ; IL-17 ; c-mip ; Nephrin ; Phosphor-nephrin ; NF-kappa B ; apoptosis
刊名: CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
发表日期: 2015
DOI: 10.1159/000430296
卷: 36, 期:4, 页:1274-1290
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cell Biology ; Physiology
研究领域[WOS]: Cell Biology ; Physiology
关键词[WOS]: REGULATORY T-CELLS ; PRIMARY NEPHROTIC SYNDROME ; NF-KAPPA-B ; GLOMERULAR-DISEASES ; TYROSINE PHOSPHORYLATION ; TH17 CELLS ; NEPHRIN ; NEPHROPATHY ; MACROPHAGES ; CYTOKINES
英文摘要:

Background/Aims: Although the disturbance of T lymphocyte and glomerular podocyte exerts a crucial function in the pathogenesis of proteinuria, the potential link is still unclear. Methods: The balance of Treg and Th17 cells, and the expression of IL-17/IL-17R and c-mip were investigated in adrimycin-induced nephropathy (AN) mice. The effect and mechanism of IL-17 on podocyte were explored in cultured podocytes. Results: The proportion of Th17 cells in peripheral blood mononuclear cells, the amount of IL-17 in serum and kidney cortical homogenates, and the expression of IL-17R and c-mip in glomerular podocyte were increased obviously in AN mice. In cultured podocytes, recombinant IL-17 led to an induction of apoptosis and cytoskeletal disorganization, an overproduction of c-mip while down-regulation of phosphor-nephrin, and an increased binding of c-mip to NF-kappa B/RelA. Silence of c-mip prevented podocyte apoptosis and reduction of phosphor-nephrin by prompting nuclear translocation of NE-kappa B/ReIA in IL-17 treated cells. Persistent activation of NE-kappa B upregulated pro-survival protein BcI-2 and decreased podocyte apoptosis, but had no effect on phosphor-nephrin level. Conclusion: These findings demonstrated that induction of IL-17 released by Th17 cells plays a key role in podocytopathy most likely through down-regulation of phosphor-nephrin and BcI-2 level via overproduction of c-mip. Copyright (C) 2015 S. Karger AG, Basel

语种: 英语
所属项目编号: 81170357 ; 30801250
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000358517300002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63418
Appears in Collections:北京大学第二临床医学院_消化内科_期刊论文

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作者单位: 1.Jilin Univ, Hosp 1, Dept Pediat, Changchun 130023, Peoples R China
2.Peking Univ Peoples Hosp, Dept Gastroenterol, Beijing 100044, Peoples R China
3.Acad Mil Med Sci, Inst Basic Med Sci, Dept Tissue Engn, Beijing, Peoples R China
4.Acad Mil Med Sci, Tissue Engn Res Ctr, Beijing, Peoples R China
5.Peking Univ Peoples Hosp, Dept Pediat, Beijing 100044, Peoples R China

Recommended Citation:
Liu, Yanbo,Su, Lin,Lin, Qiuxia,et al. Induction of C-Mip by IL-17 Plays an Important Role in Adriamycin-Induced Podocyte Damage[J]. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY,2015,36(4):1274-1290.
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