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学科主题: 公共卫生
题名:
Chrysotile-induced cell transformation and transcriptional changes of c-myc oncogene in human embryo lung cells
作者: Fan, JG; Wang, QE; Liu, SJ
刊名: BIOMEDICAL AND ENVIRONMENTAL SCIENCES
发表日期: 2000-09-01
卷: 13, 期:3, 页:163-169
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Environmental Sciences ; Public, Environmental & Occupational Health
研究领域[WOS]: Environmental Sciences & Ecology ; Public, Environmental & Occupational Health
关键词[WOS]: ASBESTOS
英文摘要:

It has been verified that asbestos induce neoplastic transformation of several rodent cell lines in vitro. Very little information is available, however, on asbestos-induced human cell line transformation and oncogene activation in the development of asbestos-induced cell transformation. This study was designed to investigate the induction of cell transformation and transcriptional changes of the myc oncogene by chrysotile asbestos fibers (CAF) in human embryo lung (HEL) cells. Surface-modified CAF soaked in aluminium citrate (AC), rare earth compounds (REC) or sodium selenite (SS) solutions were used to observe the effects of surface modification on chrysotile-induced cell. transformation and transcriptional changes in the c-myc oncogene. The results showed that the natural CAF caused dose-dependent increases in transformed foci, along with increased transcription of the c-myc oncogene in HEL cells, while the pretreated CAF induced fewer transformed foci and less c-myc oncogene transcription than the natural CAF. The percent inhibition of equivalent AC, REC and SS were 38.9%, 50.0%, 33.3% (for transformation focus), 81.6%, 69.5%, 89.9% (for c-myc oncogene transcription), respectively. These results indicated that CAF may induce cell transformation and transcriptional changes and that the carcinogenicity of CAF might he reduced by pretreatment of CAF with the above-mentioned compounds.

语种: 英语
WOS记录号: WOS:000165102400001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63419
Appears in Collections:北京大学公共卫生学院_期刊论文

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作者单位: 1.Natl Ctr Occupat Safety Sci & Technol, Beijing 100029, Peoples R China
2.Beijing Med Univ, Sch Publ Hlth, Dept Occupat Hlth, Beijing 100083, Peoples R China

Recommended Citation:
Fan, JG,Wang, QE,Liu, SJ. Chrysotile-induced cell transformation and transcriptional changes of c-myc oncogene in human embryo lung cells[J]. BIOMEDICAL AND ENVIRONMENTAL SCIENCES,2000,13(3):163-169.
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