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Chrysotile-induced cell transformation and transcriptional changes of c-myc oncogene in human embryo lung cells
Fan, JG; Wang, QE; Liu, SJ
刊名BIOMEDICAL AND ENVIRONMENTAL SCIENCES
2000-09-01
13期:3页:163-169
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Environmental Sciences ; Public, Environmental & Occupational Health
研究领域[WOS]Environmental Sciences & Ecology ; Public, Environmental & Occupational Health
关键词[WOS]ASBESTOS
英文摘要

It has been verified that asbestos induce neoplastic transformation of several rodent cell lines in vitro. Very little information is available, however, on asbestos-induced human cell line transformation and oncogene activation in the development of asbestos-induced cell transformation. This study was designed to investigate the induction of cell transformation and transcriptional changes of the myc oncogene by chrysotile asbestos fibers (CAF) in human embryo lung (HEL) cells. Surface-modified CAF soaked in aluminium citrate (AC), rare earth compounds (REC) or sodium selenite (SS) solutions were used to observe the effects of surface modification on chrysotile-induced cell. transformation and transcriptional changes in the c-myc oncogene. The results showed that the natural CAF caused dose-dependent increases in transformed foci, along with increased transcription of the c-myc oncogene in HEL cells, while the pretreated CAF induced fewer transformed foci and less c-myc oncogene transcription than the natural CAF. The percent inhibition of equivalent AC, REC and SS were 38.9%, 50.0%, 33.3% (for transformation focus), 81.6%, 69.5%, 89.9% (for c-myc oncogene transcription), respectively. These results indicated that CAF may induce cell transformation and transcriptional changes and that the carcinogenicity of CAF might he reduced by pretreatment of CAF with the above-mentioned compounds.

语种英语
WOS记录号WOS:000165102400001
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被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63419
专题北京大学公共卫生学院
作者单位1.Natl Ctr Occupat Safety Sci & Technol, Beijing 100029, Peoples R China
2.Beijing Med Univ, Sch Publ Hlth, Dept Occupat Hlth, Beijing 100083, Peoples R China
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GB/T 7714
Fan, JG,Wang, QE,Liu, SJ. Chrysotile-induced cell transformation and transcriptional changes of c-myc oncogene in human embryo lung cells[J]. BIOMEDICAL AND ENVIRONMENTAL SCIENCES,2000,13(3):163-169.
APA Fan, JG,Wang, QE,&Liu, SJ.(2000).Chrysotile-induced cell transformation and transcriptional changes of c-myc oncogene in human embryo lung cells.BIOMEDICAL AND ENVIRONMENTAL SCIENCES,13(3),163-169.
MLA Fan, JG,et al."Chrysotile-induced cell transformation and transcriptional changes of c-myc oncogene in human embryo lung cells".BIOMEDICAL AND ENVIRONMENTAL SCIENCES 13.3(2000):163-169.
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