IR@PKUHSC  > 北京大学基础医学院  > 免疫学系
学科主题基础医学
TSPY is a cancer testis antigen expressed in human hepatocellular carcinoma
Yin, YH; Li, YY; Qiao, H; Wang, HC; Yang, XA; Zhang, HG; Pang, XW; Zhang, Y; Chen, WF
关键词testis-specific protein Y-encoded hepatocellular carcinoma CT antigen antibody response immunotherapy
刊名BRITISH JOURNAL OF CANCER
2005-08-22
DOI10.1038/sj.bjc.6602716
93期:4页:458-463
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]ADAM GENE FAMILY ; PROTEIN SET ; CANCER/TESTIS ANTIGENS ; ISCOMATRIX ADJUVANT ; IDENTIFICATION ; IMMUNOTHERAPY ; RESPONSES ; CELLS ; GONADOBLASTOMA ; MICROARRAY
英文摘要

In search for genes associated with hepatocellular carcinoma (HCC) by cDNA microarray, we found that the transcription of TSPY, ′testis-specific protein Y-encoded′, was upregulated in HCC. Investigation of a broad spectrum of normal and malignant tissues by RT-PCR revealed the TSPY transcript selectively expressed in normal testis, different histological types of human neoplastic tissues, and tumour cell lines. The expression of TSPY in cancer cells was further confirmed by in situ hybridisation. Indirect immunofluorescence microscopy analysis showed that TSPY was localised mainly in the cytoplasm of transiently transfected cells. Testis-specific protein Y-encoded was detected in 50% ( 16 of 32) of well-and moderately differentiated HCC patients, in 16% ( four of 25) of poorly differentiated HCC patients, and in 5% ( one of 19) of renal cell cancer patients. A serological survey revealed that 6.6% ( seven of 106) HCC patients had anti-TSPY antibody response, demonstrating the immunogenicity of TSPY in humans. In conclusion, these data suggest that TSPY is a novel cancer/testis (CT) antigen and may be a potential candidate in vaccine strategy for immunotherapy in HCC patients.

语种英语
WOS记录号WOS:000231260400013
Citation statistics
Cited Times:36[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63420
Collection北京大学基础医学院_免疫学系
作者单位Peking Univ, Hlth Sci Ctr, Dept Immunol, Beijing 100083, Peoples R China
Recommended Citation
GB/T 7714
Yin, YH,Li, YY,Qiao, H,et al. TSPY is a cancer testis antigen expressed in human hepatocellular carcinoma[J]. BRITISH JOURNAL OF CANCER,2005,93(4):458-463.
APA Yin, YH.,Li, YY.,Qiao, H.,Wang, HC.,Yang, XA.,...&Chen, WF.(2005).TSPY is a cancer testis antigen expressed in human hepatocellular carcinoma.BRITISH JOURNAL OF CANCER,93(4),458-463.
MLA Yin, YH,et al."TSPY is a cancer testis antigen expressed in human hepatocellular carcinoma".BRITISH JOURNAL OF CANCER 93.4(2005):458-463.
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