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学科主题: 药学
题名:
A resveratrol analog, phoyunbene B, induces G2/M cell cycle arrest and apoptosis in HepG2 liver cancer cells
作者: Wang, Guanghui1; Guo, Xiaoyu2; Chen, Haifeng1; Lin, Ting1; Xu, Yang1; Chen, Quancheng1; Liu, Jie1; Zeng, Jinzhang1; Zhang, Xiao-kun1; Yao, Xinsheng3
关键词: Phoyunbene B ; Resveratrol ; Cell cycle ; Apoptosis
刊名: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
发表日期: 2012-03-01
DOI: 10.1016/j.bmcl.2011.12.095
卷: 22, 期:5, 页:2114-2118
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Medicinal ; Chemistry, Organic
研究领域[WOS]: Pharmacology & Pharmacy ; Chemistry
关键词[WOS]: BCL-2 PROTEIN FAMILY ; LEUKEMIA CELLS ; RIBONUCLEOTIDE REDUCTASE ; GROWTH ; PROLIFERATION ; GRAPES
英文摘要:

Among the seven natural resveratrol analogs separated and identified from Pholidota yunnanensis R-OLFE, we found phoyunbene B (PYB, trans-3,4′-dihydroxy-2′,3′,5-trimethoxystilbene) was more effective in inhibiting the growth of HepG2 hepatocellular carcinoma cells than resveratrol. The inhibitory effect of PYB in HepG2 cells was due to its induction of G2/M cell cycle arrest and apoptosis. Induction of G2/M phase cell cycle arrest by PYB was associated with its up-regulation of Cyclin B1, while its induction of apoptosis was accompanied with its down-regulation of Bcl-2 and up-regulation of Bax. Our in vitro invasion/migration assays also showed that PYB could inhibit the invasion of hepatocellular carcinoma cells. (C) 2012 Elsevier Ltd. All rights reserved.

语种: 英语
所属项目编号: NSFC-81001664 ; 2010121100 ; 3502Z20100006 ; 2011121058
项目资助者: National Natural Science Foundation of China ; Fundamental Research Funds for the Central Universities ; Xiamen Science and Technology Key program ; Xiamen University
WOS记录号: WOS:000300451200055
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63423
Appears in Collections:北京大学药学院_天然药物学系_期刊论文

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作者单位: 1.Xiamen Univ, Sch Pharmaceut Sci, Xiamen 361005, Fujian, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, Dept Nat Med, Beijing 100191, Peoples R China
3.Jinan Univ, Coll Pharm, Inst Tradit Chinese Med & Nat Prod, Guangzhou 510632, Guangdong, Peoples R China

Recommended Citation:
Wang, Guanghui,Guo, Xiaoyu,Chen, Haifeng,et al. A resveratrol analog, phoyunbene B, induces G2/M cell cycle arrest and apoptosis in HepG2 liver cancer cells[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2012,22(5):2114-2118.
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