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学科主题: 基础医学
题名:
Peroxisome proliferator-activated receptor-alpha deficiency protects aged mice from insulin resistance induced by high-fat diet
作者: Cha, Dae Ryong; Han, Jee Young; Su, Dong Ming; Zhang, Yahua; Fan, Xuefeng; Breyer, Matthew D.; Guan, Youfei
关键词: peroxisome proliferator-activated receptor-alpha ; insulin resistance ; high-fat diet ; aged mice
刊名: AMERICAN JOURNAL OF NEPHROLOGY
发表日期: 2007
DOI: 10.1159/000106485
卷: 27, 期:5, 页:479-482
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Urology & Nephrology
研究领域[WOS]: Urology & Nephrology
关键词[WOS]: NULL MICE ; SENSITIVITY ; CYCLE
英文摘要:

Background/Aims: Insulin resistance is a central feature of the metabolic syndrome and progressively increases with age, resulting in excessively high incidence of type II diabetes in the elderly population. Peroxisome proliferator-activated receptor-alpha (PPAR alpha) is widely expressed in insulin target tissues, including those of the liver, kidney, and muscle, where it mediates expression of genes promoting fatty acid beta-oxidation. The aim of this study was to evaluate the potential role of PPAR alpha in insulin resistance in aging mice induced by a high-fat diet. Methods: We used male PPAR alpha knockout (KO) mice and wild-type (WT) littermates that were 18 months old. Animals were fed with a high-fat diet (HFD) for 4 weeks, and metabolic parameters associated with insulin sensitivity were assessed. Results: Following HFD treatment, WT mice showed more severe insulin resistance than did mice lacking the PPAR alpha gene, as assessed by both the glucose tolerance test (GTT) and insulin tolerance test (ITT). In addition, WT mice exhibited significantly higher HOMA-IR, plasma total cholesterol levels and urinary albumin-creatinine ratio but less liver weight than did PPAR alpha KO mice. Conclusion: These data suggest that PPAR alpha gene deficiency may protect aged mice from developing insulin resistance and albuminuria induced by a HFD. Copyright (c) 2007 S. Karger AG, Basel.

语种: 英语
WOS记录号: WOS:000249008800006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63424
Appears in Collections:基础医学院_北京大学糖尿病中心_期刊论文

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作者单位: 1.Korea Univ, Div Nephrol, Seoul 136701, South Korea
2.Vanderbilt Univ, Ctr Med, Dept Med, Div Nephrol & Hypertens, Nashville, TN 37232 USA
3.Peking Univ, Beijing 100871, Peoples R China
4.Peking Univ, Hlth Sci Ctr, Ctr Diabet, Beijing 100871, Peoples R China

Recommended Citation:
Cha, Dae Ryong,Han, Jee Young,Su, Dong Ming,et al. Peroxisome proliferator-activated receptor-alpha deficiency protects aged mice from insulin resistance induced by high-fat diet[J]. AMERICAN JOURNAL OF NEPHROLOGY,2007,27(5):479-482.
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