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Peroxisome proliferator-activated receptor-alpha deficiency protects aged mice from insulin resistance induced by high-fat diet
Cha, Dae Ryong; Han, Jee Young; Su, Dong Ming; Zhang, Yahua; Fan, Xuefeng; Breyer, Matthew D.; Guan, Youfei
关键词peroxisome proliferator-activated receptor-alpha insulin resistance high-fat diet aged mice
刊名AMERICAN JOURNAL OF NEPHROLOGY
2007
DOI10.1159/000106485
27期:5页:479-482
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Urology & Nephrology
研究领域[WOS]Urology & Nephrology
关键词[WOS]NULL MICE ; SENSITIVITY ; CYCLE
英文摘要

Background/Aims: Insulin resistance is a central feature of the metabolic syndrome and progressively increases with age, resulting in excessively high incidence of type II diabetes in the elderly population. Peroxisome proliferator-activated receptor-alpha (PPAR alpha) is widely expressed in insulin target tissues, including those of the liver, kidney, and muscle, where it mediates expression of genes promoting fatty acid beta-oxidation. The aim of this study was to evaluate the potential role of PPAR alpha in insulin resistance in aging mice induced by a high-fat diet. Methods: We used male PPAR alpha knockout (KO) mice and wild-type (WT) littermates that were 18 months old. Animals were fed with a high-fat diet (HFD) for 4 weeks, and metabolic parameters associated with insulin sensitivity were assessed. Results: Following HFD treatment, WT mice showed more severe insulin resistance than did mice lacking the PPAR alpha gene, as assessed by both the glucose tolerance test (GTT) and insulin tolerance test (ITT). In addition, WT mice exhibited significantly higher HOMA-IR, plasma total cholesterol levels and urinary albumin-creatinine ratio but less liver weight than did PPAR alpha KO mice. Conclusion: These data suggest that PPAR alpha gene deficiency may protect aged mice from developing insulin resistance and albuminuria induced by a HFD. Copyright (c) 2007 S. Karger AG, Basel.

语种英语
WOS记录号WOS:000249008800006
引用统计
被引频次:13[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63424
专题北京大学基础医学院_北京大学糖尿病中心
作者单位1.Korea Univ, Div Nephrol, Seoul 136701, South Korea
2.Vanderbilt Univ, Ctr Med, Dept Med, Div Nephrol & Hypertens, Nashville, TN 37232 USA
3.Peking Univ, Beijing 100871, Peoples R China
4.Peking Univ, Hlth Sci Ctr, Ctr Diabet, Beijing 100871, Peoples R China
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GB/T 7714
Cha, Dae Ryong,Han, Jee Young,Su, Dong Ming,et al. Peroxisome proliferator-activated receptor-alpha deficiency protects aged mice from insulin resistance induced by high-fat diet[J]. AMERICAN JOURNAL OF NEPHROLOGY,2007,27(5):479-482.
APA Cha, Dae Ryong.,Han, Jee Young.,Su, Dong Ming.,Zhang, Yahua.,Fan, Xuefeng.,...&Guan, Youfei.(2007).Peroxisome proliferator-activated receptor-alpha deficiency protects aged mice from insulin resistance induced by high-fat diet.AMERICAN JOURNAL OF NEPHROLOGY,27(5),479-482.
MLA Cha, Dae Ryong,et al."Peroxisome proliferator-activated receptor-alpha deficiency protects aged mice from insulin resistance induced by high-fat diet".AMERICAN JOURNAL OF NEPHROLOGY 27.5(2007):479-482.
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