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学科主题: 基础医学
题名:
Immunoglobulin G (IgG) Expression in Human Umbilical Cord Endothelial Cells
作者: Zhao, Yingying1; Liu, Yuxuan1; Chen, Zhengshan2; Korteweg, Christine2; Gu, Jiang1,2
关键词: IgG ; human ; umbilical cord ; endothelial cell ; expression ; V(D)J recombination
刊名: JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY
发表日期: 2011-05-01
DOI: 10.1369/0022155411400871
卷: 59, 期:5, 页:474-488
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cell Biology
研究领域[WOS]: Cell Biology
关键词[WOS]: FC-RECEPTOR ; MOLECULAR PATHOLOGY ; HUMAN PLACENTA ; T-LYMPHOCYTES ; IN-VITRO ; BLOOD ; ALLOANTIGENICITY ; LIPOPROTEIN ; ANTIBODIES ; GROWTH
英文摘要:

Traditional views hold that immunoglobulin G (IgG) in the human umbilical cord is internalized by human umbilical endothelial cells for passive immunity. In this study, the protein and mRNA transcripts of IgG were found in the cytoplasm of human umbilical endothelial cells by immunohistochemistry, in situ hybridization, and reverse transcription PCR (RT-PCR). The essential enzymes for IgG synthesis and assembling, RAG1 (recombination activating gene 1), RAG2, and variable (V), diversity (D), and joining (J) segments for recombination of IgG, were also found in these cells by RT-PCR and real-time PCR. These results indicate that umbilical endothelial cells are capable of synthesizing IgG with properties similar to those of immune cells and that they may play additional roles besides lining the vessels and transporting IgG. (J Histochem Cytochem 59:474-488, 2011)

语种: 英语
所属项目编号: B 07001 ; 30950110335 ; 30971150
项目资助者: International Collaboration Project (111 Project) ; National Natural Science Foundation of China
WOS记录号: WOS:000293703400002
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63426
Appears in Collections:基础医学院_病理学系_期刊论文

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作者单位: 1.Peking Univ, Dept Pathol, Sch Basic Med Sci, Beijing 100871, Peoples R China
2.Shantou Univ, Dept Pathol, Coll Med, Shantou, Peoples R China

Recommended Citation:
Zhao, Yingying,Liu, Yuxuan,Chen, Zhengshan,et al. Immunoglobulin G (IgG) Expression in Human Umbilical Cord Endothelial Cells[J]. JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY,2011,59(5):474-488.
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