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学科主题基础医学
Immunoglobulin G (IgG) Expression in Human Umbilical Cord Endothelial Cells
Zhao, Yingying1; Liu, Yuxuan1; Chen, Zhengshan2; Korteweg, Christine2; Gu, Jiang1,2
关键词IgG human umbilical cord endothelial cell expression V(D)J recombination
刊名JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY
2011-05-01
DOI10.1369/0022155411400871
59期:5页:474-488
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cell Biology
研究领域[WOS]Cell Biology
关键词[WOS]FC-RECEPTOR ; MOLECULAR PATHOLOGY ; HUMAN PLACENTA ; T-LYMPHOCYTES ; IN-VITRO ; BLOOD ; ALLOANTIGENICITY ; LIPOPROTEIN ; ANTIBODIES ; GROWTH
英文摘要

Traditional views hold that immunoglobulin G (IgG) in the human umbilical cord is internalized by human umbilical endothelial cells for passive immunity. In this study, the protein and mRNA transcripts of IgG were found in the cytoplasm of human umbilical endothelial cells by immunohistochemistry, in situ hybridization, and reverse transcription PCR (RT-PCR). The essential enzymes for IgG synthesis and assembling, RAG1 (recombination activating gene 1), RAG2, and variable (V), diversity (D), and joining (J) segments for recombination of IgG, were also found in these cells by RT-PCR and real-time PCR. These results indicate that umbilical endothelial cells are capable of synthesizing IgG with properties similar to those of immune cells and that they may play additional roles besides lining the vessels and transporting IgG. (J Histochem Cytochem 59:474-488, 2011)

语种英语
WOS记录号WOS:000293703400002
项目编号B 07001 ; 30950110335 ; 30971150
资助机构International Collaboration Project (111 Project) ; National Natural Science Foundation of China
引用统计
被引频次:16[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63426
专题北京大学基础医学院_病理学系
作者单位1.Peking Univ, Dept Pathol, Sch Basic Med Sci, Beijing 100871, Peoples R China
2.Shantou Univ, Dept Pathol, Coll Med, Shantou, Peoples R China
推荐引用方式
GB/T 7714
Zhao, Yingying,Liu, Yuxuan,Chen, Zhengshan,et al. Immunoglobulin G (IgG) Expression in Human Umbilical Cord Endothelial Cells[J]. JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY,2011,59(5):474-488.
APA Zhao, Yingying,Liu, Yuxuan,Chen, Zhengshan,Korteweg, Christine,&Gu, Jiang.(2011).Immunoglobulin G (IgG) Expression in Human Umbilical Cord Endothelial Cells.JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY,59(5),474-488.
MLA Zhao, Yingying,et al."Immunoglobulin G (IgG) Expression in Human Umbilical Cord Endothelial Cells".JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY 59.5(2011):474-488.
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