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学科主题: 临床医学
题名:
The effects of MOTILIPERM on cisplatin induced testicular toxicity in Sprague-Dawley rats
作者: Soni, Kiran Kumar1; Zhang, Li Tao1; You, Jae Hyung1; Lee, Sung Won4; Kim, Chul Young5; Cui, Wan Shou6; Chae, Han Jung7; Kim, Hye Kyung1; Park, Jong Kwan1,2,3
关键词: Cispaltin (CIS) ; MOTILIPERM ; Spermatogenic cell denity ; Steroidogenic acute regulatory (StAR) protein ; Glucose-regulated protein-78 (GRP-78) ; Phosphorylated inositol-requiring transmembrane kinase/endoribonuclease 1 (IRE1) ; Phosphorylated c-jun-N-terminal kinase (p-JNK)
刊名: CANCER CELL INTERNATIONAL
发表日期: 2015-12-18
DOI: 10.1186/s12935-015-0274-1
卷: 15
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: CIS-DIAMMINEDICHLOROPLATINUM ; ENDOPLASMIC-RETICULUM ; SIGNALING PATHWAYS ; PROTEIN-KINASE ; CELL-DEATH ; TESTIS ; CANCER ; SPERMATOGENESIS ; TESTOSTERONE ; EXPRESSION
英文摘要:

Background: Cisplatin causes male infertility but the exact mechanism have not been clarified, yet. MOTILIPERM has been implicated in alleviation of infertility in Sprague-Dawley rats caused by cisplatin. We evaluated recovery effect of MOTILIPERM on cisplatin (CIS)-induced testicular toxicity in Sprague-Dawley rats.

Methods: Five groups were included. The groups are control (CTR), CTR + MOTILIPERM 200 mg/kg/day per oral, CIS 10 mg/kg i.v., CIS 10 mg/kg + MOTILIPERM 100 mg/kg/day, CIS 10 mg/kg + MOTILIPERM 200 mg/kg/day. CIS 10 mg/kg i.v. single dose was given before 100 mg/kg, or 200 mg/kg MOTILIPERM per oral daily for 28 days. Body and genital organs weight, epididymis sperm count, sperm motility, sperm apoptosis, testosterone level, MDA of testis tissue, spermatogenic cell density, and Johnsen′s score were evaluated. Steroidogenic acute regulatory (StAR) protein, and Glucose-regulated protein-78 (GRP-78), phosphorylated Inositol-Requiring Transmembrane Kinase/Endoribonuclease 1 (IRE1) and phosphorylated c-jun-N-terminal kinase (p-JNK) were quantitated by western blot to show its signaling pathway.

Results: The body weight was decreased significantly in CIS 10 mg/kg, CIS 10 mg/kg + MOTILIPERM 100 mg/kg/day, CIS 10 mg/kg + MOTILIPERM 200 mg/kg/day compared with CTR (p < 0.001) however, it was increased in CIS 10 mg/kg + MOTILIPERM 100 mg/kg/day, CIS 10 mg/kg + MOTILIPERM 200 mg/kg/day compared with CIS 10 mg/kg. The decreased weight of epididymis and prostate were increased significantly in CIS 10 mg/kg + MOTILIPERM 100 mg/kg/day compared with CIS 10 mg/kg. Sperm count, sperm motility, sperm apoptosis, MDA of testis tissue, spermatogenic cell density, Johnsen′s score, and total testosterone were also significantly improved by MOTILIPERM treatment. The levels of decreased StAR protein was significantly improved by MOTILIPERM administration, increased GRP-78 protein p-IRE1 and p-JNK was also significantly decreased with MOTILIPREM treatment.

Conclusion: The MOTILIPERM could be an effective medicine to reduce the toxic effect caused ER stress by CIS in the testis.

语种: 英语
所属项目编号: HI14C0018
项目资助者: Korea Healthcare Technology R&amp ; D Project, Ministry for Health, Welfare &amp ; Family Affairs, Republic of Korea
WOS记录号: WOS:000366974500003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63428
Appears in Collections:北京大学第一临床医学院_男科中心_期刊论文

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作者单位: 1.Chonbuk Natl Univ, Sch Med, Dept Urol, Inst Med Sci, Jeonju 561712, South Korea
2.Chonbuk Natl Univ Hosp, Biomed Res Inst, Jeonju 561712, South Korea
3.Chonbuk Natl Univ Hosp, Clin Trial Ctr Med Devices, Jeonju 561712, South Korea
4.Sungkyunkwan Univ, Sch Med, Samsung Biomed Res Inst, Dept Urol,Samsung Med Ctr, Seoul, South Korea
5.Hangyang Univ, Coll Pharm, Ansan 426791, South Korea
6.Peking Univ, Hosp 1, Androl Ctr, Beijing 100034, Peoples R China
7.Chonbuk Natl Univ, Sch Med, Dept Pharmacol, Jeonju, South Korea

Recommended Citation:
Soni, Kiran Kumar,Zhang, Li Tao,You, Jae Hyung,et al. The effects of MOTILIPERM on cisplatin induced testicular toxicity in Sprague-Dawley rats[J]. CANCER CELL INTERNATIONAL,2015,15.
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