北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学药学院  > 药剂学系  > 期刊论文
学科主题: 药学
题名:
Nasal insulin delivery in the chitosan solution: in vitro and in vivo studies
作者: Yu, SY; Zhao, Y; Wu, FL; Zhang, X; Lu, WL; Zhang, H; Zhang, Q
关键词: nasal delivery ; insulin ; chitosan ; permeability ; bioavailability rats
刊名: INTERNATIONAL JOURNAL OF PHARMACEUTICS
发表日期: 2004-08-20
DOI: 10.1016/j.ijpharm.2004.05.007
卷: 281, 期:1-2, 页:11-23
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: TIGHT JUNCTIONS ; DRUG-DELIVERY ; ABSORPTION ; NANOPARTICLES ; CYCLODEXTRINS ; PERMEABILITY ; ENHANCERS ; RATS ; FORMULATION ; MONOLAYERS
英文摘要:

The effects of chitosan concentrations, osmolarity, medium and absorption enhancers in the chitosan solution on nasal insulin delivery were studied in vitro and in vivo. The penetration of insulin through the mucosa of rabbit nasal septum was investigated by measuring the transmucosal flux in vitro, while the nasal absorption of insulin in vivo was assessed by the efficiency in lowering the blood glucose levels in normal rats. It was demonstrated that increasing concentrations of chitosan up to 1.5% (w/v) caused an increase in the permeability of insulin across the nasal mucosa. Insulin given intranasally in hypo- or hyperosmotic formulation showed a higher hypoglycemic effect than insulin delivered in isoosmotic formulation. Insulin formulation in chitosan solution prepared with deionized water brought to a higher relative pharmacological bioavailability (Fr) value than that prepared with 50 mM pH 7.4 phosphate buffer. A formulation containing both 1% chitosan and 0.1% ethylenediaminetetraacetic acid (EDTA), 5% polysorbate 80 (Tween 80) or 1.2% beta-cyclodextrin (beta-CD) did not lead to a higher Fr than insulin formulated with 1% chitosan alone. The formulation containing both 5% hydroxypropyl-beta-cyclodextrin (HP-beta-CD) and 1% chitosan was more effective at reducing blood glucose levels than the formulation containing 5% HP-P-CD or 1% chitosan alone. The studies indicated that chitosan concentrations, osmolarity, medium and absorption enhancers in chitosan solution have significant effect on the insulin nasal delivers. The results of in vitro experiments were in good agreement with that of in vivo studies. (C) 2004 Elsevier B.V. All rights reserved.

语种: 英语
WOS记录号: WOS:000223499300002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63429
Appears in Collections:北京大学药学院_药剂学系_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: Peking Univ, Hlth Sci Ctr, Dept Pharmaceut, Beijing 100083, Peoples R China

Recommended Citation:
Yu, SY,Zhao, Y,Wu, FL,et al. Nasal insulin delivery in the chitosan solution: in vitro and in vivo studies[J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS,2004,281(1-2):11-23.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Yu, SY]'s Articles
[Zhao, Y]'s Articles
[Wu, FL]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Yu, SY]‘s Articles
[Zhao, Y]‘s Articles
[Wu, FL]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace