IR@PKUHSC  > 北京大学药学院  > 药剂学系
学科主题药学
Nasal insulin delivery in the chitosan solution: in vitro and in vivo studies
Yu, SY; Zhao, Y; Wu, FL; Zhang, X; Lu, WL; Zhang, H; Zhang, Q
关键词nasal delivery insulin chitosan permeability bioavailability rats
刊名INTERNATIONAL JOURNAL OF PHARMACEUTICS
2004-08-20
DOI10.1016/j.ijpharm.2004.05.007
281期:1-2页:11-23
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]TIGHT JUNCTIONS ; DRUG-DELIVERY ; ABSORPTION ; NANOPARTICLES ; CYCLODEXTRINS ; PERMEABILITY ; ENHANCERS ; RATS ; FORMULATION ; MONOLAYERS
英文摘要

The effects of chitosan concentrations, osmolarity, medium and absorption enhancers in the chitosan solution on nasal insulin delivery were studied in vitro and in vivo. The penetration of insulin through the mucosa of rabbit nasal septum was investigated by measuring the transmucosal flux in vitro, while the nasal absorption of insulin in vivo was assessed by the efficiency in lowering the blood glucose levels in normal rats. It was demonstrated that increasing concentrations of chitosan up to 1.5% (w/v) caused an increase in the permeability of insulin across the nasal mucosa. Insulin given intranasally in hypo- or hyperosmotic formulation showed a higher hypoglycemic effect than insulin delivered in isoosmotic formulation. Insulin formulation in chitosan solution prepared with deionized water brought to a higher relative pharmacological bioavailability (Fr) value than that prepared with 50 mM pH 7.4 phosphate buffer. A formulation containing both 1% chitosan and 0.1% ethylenediaminetetraacetic acid (EDTA), 5% polysorbate 80 (Tween 80) or 1.2% beta-cyclodextrin (beta-CD) did not lead to a higher Fr than insulin formulated with 1% chitosan alone. The formulation containing both 5% hydroxypropyl-beta-cyclodextrin (HP-beta-CD) and 1% chitosan was more effective at reducing blood glucose levels than the formulation containing 5% HP-P-CD or 1% chitosan alone. The studies indicated that chitosan concentrations, osmolarity, medium and absorption enhancers in chitosan solution have significant effect on the insulin nasal delivers. The results of in vitro experiments were in good agreement with that of in vivo studies. (C) 2004 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000223499300002
引用统计
被引频次:58[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63429
专题北京大学药学院_药剂学系
作者单位Peking Univ, Hlth Sci Ctr, Dept Pharmaceut, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Yu, SY,Zhao, Y,Wu, FL,et al. Nasal insulin delivery in the chitosan solution: in vitro and in vivo studies[J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS,2004,281(1-2):11-23.
APA Yu, SY.,Zhao, Y.,Wu, FL.,Zhang, X.,Lu, WL.,...&Zhang, Q.(2004).Nasal insulin delivery in the chitosan solution: in vitro and in vivo studies.INTERNATIONAL JOURNAL OF PHARMACEUTICS,281(1-2),11-23.
MLA Yu, SY,et al."Nasal insulin delivery in the chitosan solution: in vitro and in vivo studies".INTERNATIONAL JOURNAL OF PHARMACEUTICS 281.1-2(2004):11-23.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Yu, SY]的文章
[Zhao, Y]的文章
[Wu, FL]的文章
百度学术
百度学术中相似的文章
[Yu, SY]的文章
[Zhao, Y]的文章
[Wu, FL]的文章
必应学术
必应学术中相似的文章
[Yu, SY]的文章
[Zhao, Y]的文章
[Wu, FL]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。