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学科主题: 临床医学
题名:
A Study on Repair of Porcine Articular Cartilage Defects With Tissue-Engineered Cartilage Constructed In Vivo By Composite Scaffold Materials
作者: Lin, Pan B.; Ning, Li J.; Lian, Qin Z.; Xia, Zhao; Xin, Yang; Sen, Bi H.; Fei, Nie F.
关键词: cartilage microparticle acellular tissue matrix ; acellular cartilage ; fibrin glue ; injectable tissue-engineered cartilage
刊名: ANNALS OF PLASTIC SURGERY
发表日期: 2010-10-01
DOI: 10.1097/SAP.0b013e3181d6e38b
卷: 65, 期:4, 页:430-436
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Surgery
研究领域[WOS]: Surgery
关键词[WOS]: AUTOLOGOUS CHONDROCYTE TRANSPLANTATION ; INJECTABLE CARTILAGE ; CELL TRANSPLANTATION ; POLYMER ; MATRIX ; KNEE ; IMPLANTATION ; GRAFTS ; TRIAL ; BONE
英文摘要:

The study was performed to find out a promising injectable composite scaffold for cartilage tissue engineering. By using a composite of allogenous cartilage microparticle acellular tissue matrix (CMACTM) and fibrin glue (Fg) as injectable scaffold materials, tissue-engineered cartilage was constructed in vivo, and the effects of which on the repair of porcine articular cartilage defects were observed.

CMACTM was obtained from domestic pigs. The chondrocytes were prepared from experimental mini-type pigs and expanded in vitro. Fg was used as a scaffold material. The composite of CMACTM, second-passage chondrocytes, and Fg was replanted to the articular cartilage defective regions in autologous mini-type pig by injection. At 12 weeks after replantation, samples were collected and analyzed by general observation and histologic staining.

The constructed tissue-engineered cartilage exhibited a good efficiency in the repair of articular cartilage defects. Cells in the constructed tissue-engineered cartilage grew well and were able to secrete cartilaginous matrix. The tissue-engineered cartilage showed a better biologic performance than the control.

A composite of allogenous CMACTM and Fg was a promising injectable scaffold for cartilage tissue engineering, which could be used to repair articular cartilage defects by a minimally invasive procedure.

语种: 英语
项目资助者: National Natural Science Foundation of China (NSFC)
WOS记录号: WOS:000282134900013
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63432
Appears in Collections:北京大学第三临床医学院_成形外科_期刊论文

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作者单位: Peking Univ, Hosp 3, Dept Plast Surg, Beijing 100191, Peoples R China

Recommended Citation:
Lin, Pan B.,Ning, Li J.,Lian, Qin Z.,et al. A Study on Repair of Porcine Articular Cartilage Defects With Tissue-Engineered Cartilage Constructed In Vivo By Composite Scaffold Materials[J]. ANNALS OF PLASTIC SURGERY,2010,65(4):430-436.
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