IR@PKUHSC  > 北京大学第三临床医学院  > 成形外科
学科主题临床医学
A Study on Repair of Porcine Articular Cartilage Defects With Tissue-Engineered Cartilage Constructed In Vivo By Composite Scaffold Materials
Lin, Pan B.; Ning, Li J.; Lian, Qin Z.; Xia, Zhao; Xin, Yang; Sen, Bi H.; Fei, Nie F.
关键词cartilage microparticle acellular tissue matrix acellular cartilage fibrin glue injectable tissue-engineered cartilage
刊名ANNALS OF PLASTIC SURGERY
2010-10-01
DOI10.1097/SAP.0b013e3181d6e38b
65期:4页:430-436
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Surgery
研究领域[WOS]Surgery
关键词[WOS]AUTOLOGOUS CHONDROCYTE TRANSPLANTATION ; INJECTABLE CARTILAGE ; CELL TRANSPLANTATION ; POLYMER ; MATRIX ; KNEE ; IMPLANTATION ; GRAFTS ; TRIAL ; BONE
英文摘要

The study was performed to find out a promising injectable composite scaffold for cartilage tissue engineering. By using a composite of allogenous cartilage microparticle acellular tissue matrix (CMACTM) and fibrin glue (Fg) as injectable scaffold materials, tissue-engineered cartilage was constructed in vivo, and the effects of which on the repair of porcine articular cartilage defects were observed.

CMACTM was obtained from domestic pigs. The chondrocytes were prepared from experimental mini-type pigs and expanded in vitro. Fg was used as a scaffold material. The composite of CMACTM, second-passage chondrocytes, and Fg was replanted to the articular cartilage defective regions in autologous mini-type pig by injection. At 12 weeks after replantation, samples were collected and analyzed by general observation and histologic staining.

The constructed tissue-engineered cartilage exhibited a good efficiency in the repair of articular cartilage defects. Cells in the constructed tissue-engineered cartilage grew well and were able to secrete cartilaginous matrix. The tissue-engineered cartilage showed a better biologic performance than the control.

A composite of allogenous CMACTM and Fg was a promising injectable scaffold for cartilage tissue engineering, which could be used to repair articular cartilage defects by a minimally invasive procedure.

语种英语
WOS记录号WOS:000282134900013
资助机构National Natural Science Foundation of China (NSFC)
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63432
专题北京大学第三临床医学院_成形外科
作者单位Peking Univ, Hosp 3, Dept Plast Surg, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Lin, Pan B.,Ning, Li J.,Lian, Qin Z.,et al. A Study on Repair of Porcine Articular Cartilage Defects With Tissue-Engineered Cartilage Constructed In Vivo By Composite Scaffold Materials[J]. ANNALS OF PLASTIC SURGERY,2010,65(4):430-436.
APA Lin, Pan B..,Ning, Li J..,Lian, Qin Z..,Xia, Zhao.,Xin, Yang.,...&Fei, Nie F..(2010).A Study on Repair of Porcine Articular Cartilage Defects With Tissue-Engineered Cartilage Constructed In Vivo By Composite Scaffold Materials.ANNALS OF PLASTIC SURGERY,65(4),430-436.
MLA Lin, Pan B.,et al."A Study on Repair of Porcine Articular Cartilage Defects With Tissue-Engineered Cartilage Constructed In Vivo By Composite Scaffold Materials".ANNALS OF PLASTIC SURGERY 65.4(2010):430-436.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Lin, Pan B.]的文章
[Ning, Li J.]的文章
[Lian, Qin Z.]的文章
百度学术
百度学术中相似的文章
[Lin, Pan B.]的文章
[Ning, Li J.]的文章
[Lian, Qin Z.]的文章
必应学术
必应学术中相似的文章
[Lin, Pan B.]的文章
[Ning, Li J.]的文章
[Lian, Qin Z.]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。