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Association of IRF5 gene polymorphisms and lupus nephritis in a Chinese population
Qin, Lianxiang1,2,3; Lv, Jicheng1,2; Zhou, Xujie1,2; Hou, Ping1,2; Yang, Haizhen4; Zhang, Hong1,2
关键词gene polymorphism interferon regulatory factor 5 lupus nephritis systemic lupus erythematosus
刊名NEPHROLOGY
2010-10-01
DOI10.1111/j.1440-1797.2010.01327.x
15期:7页:710-713
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Urology & Nephrology
研究领域[WOS]Urology & Nephrology
关键词[WOS]I INTERFERON ; AUTOIMMUNE-DISEASES ; ERYTHEMATOSUS ; HAPLOTYPE ; RISK ; EXPRESSION ; ALPHA
英文摘要

Aim:

Recently, several studies have provided convincing evidence that polymorphisms in the interferon regulatory factor 5 (IRF5) gene were significantly associated with systemic lupus erythematosus (SLE) in several populations. The aim of this study was to investigate the association between IRF5 and lupus nephritis in a Chinese cohort and analyze the relationship between the rs2004640 genotype and the clinical and pathological phenotypes of lupus nephritis.

Methods:

The IRF5 rs2004640 polymorphism in a cohort of 190 Chinese lupus nephritis patients and 182 healthy Chinese blood donors was analyzed. The polymorphism examined was genotyped using the TaqMan assay.

Results:

The IRF5 rs2004640 T allele was associated with the susceptibility to lupus nephritis (rs2004640 T, 41.6% in patients, 30.8% in healthy controls, odds ratio = 1.6, P = 0.002). It was also found that the Chinese population had a much lower minor allele frequency of rs2004640 than Western populations studied to date. In the present cohort, 30.8% individuals in the control group had the detrimental T allele, compared to frequencies in the range of 44-56% that exist in Western populations. No association was found between IRF5 rs2004640 and pathology, or clinical presentation of lupus nephritis in the Chinese cohort examined.

Conclusion:

The results suggested that the rs2004640 T allele was associated with susceptibility to lupus nephritis and that the IRF5 polymorphism analyzed did not seem to be implicated in the pathology and clinical manifestation of lupus nephritis in the Chinese population.

语种英语
WOS记录号WOS:000282877300006
项目编号985-2-2007-113 ; 30825021 ; 30801022
资助机构Foundation of Ministry of Education of China ; National Natural Science Foundation of China
引用统计
被引频次:19[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63433
专题北京大学第一临床医学院_肾脏内科
作者单位1.Aerosp Ctr Hosp, Dept Nephrol, Beijing, Peoples R China
2.Peking Univ First Hosp, Dept Dermatol, Beijing, Peoples R China
3.Minist Hlth China, Key Lab Renal Dis, Beijing, Peoples R China
4.Peking Univ, Peking Univ Hosp 1, Inst Nephrol, Div Renal,Dept Med, Beijing 100034, Peoples R China
推荐引用方式
GB/T 7714
Qin, Lianxiang,Lv, Jicheng,Zhou, Xujie,et al. Association of IRF5 gene polymorphisms and lupus nephritis in a Chinese population[J]. NEPHROLOGY,2010,15(7):710-713.
APA Qin, Lianxiang,Lv, Jicheng,Zhou, Xujie,Hou, Ping,Yang, Haizhen,&Zhang, Hong.(2010).Association of IRF5 gene polymorphisms and lupus nephritis in a Chinese population.NEPHROLOGY,15(7),710-713.
MLA Qin, Lianxiang,et al."Association of IRF5 gene polymorphisms and lupus nephritis in a Chinese population".NEPHROLOGY 15.7(2010):710-713.
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