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学科主题: 临床医学
题名:
Female Fertility: Is it Safe to "Freeze?"
作者: Zhang, Lu; Yan, Li-Ying; Zhi, Xu; Yan, Jie; Qiao, Jie
关键词: Embryo Cryopreservation ; Oocyte Cryopreservation ; Ovarian Tissue Cryopreservation
刊名: CHINESE MEDICAL JOURNAL
发表日期: 2015-02-05
DOI: 10.4103/0366-6999.150115
卷: 128, 期:3, 页:390-397
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: CRYOPRESERVED OVARIAN TISSUE ; IN-VITRO FERTILIZATION ; HUMAN OOCYTE CRYOPRESERVATION ; BONE-MARROW-TRANSPLANTATION ; IMPAIRED ENDOMETRIAL RECEPTIVITY ; ASSISTED REPRODUCTIVE TECHNOLOGY ; INTRACYTOPLASMIC SPERM INJECTION ; GERMINAL VESICLE STAGE ; IMMATURE HUMAN OOCYTES ; TRIAL COMPARING FRESH
英文摘要:

Objective: To evaluate the safety and risk of cryopreservation in female fertility preservation.

Data sources: The data analyzed in this review were the English articles from 1980 to 2013 fromj ournal databases, primarily PubMed and Google scholar. The criteria used in the literature search show as following: (1) human; embryo; cryopreservation/freezing/vitrification, (2) human; oocyte/immature oocyte; cryopreservation/freezing/vitrification, (3) human; ovarian tissue transplantation; cryopreservation/ freezing/vitrification, (4) human; aneuploidy/DNA damage/epigenetic; cryopreservation/freezing/vitrification, and (5) human; fertility preservation; maternal age.

Study selection: The risk ratios based on survival rate, maturation rate, fertilization rate, cleavage rate, implantation rate, pregnancy rate, and clinical risk rate were acquired from relevant meta-analysis studies. These studies included randomized controlled trials or studies with one of the primary outcome measures covering cryopreservation of human mature oocytes, embryos, and ovarian tissues within the last 7 years (from 2006 to 2013, since the pregnancy rates of oocyte vitrification were significantly increased due to the improved techniques). The data involving immature oocyte cryopreservation obtained from individual studies was also reviewed by the authors.

Results: Vitrifications of mature oocytes and embryos obtained better clinical outcomes and did not increase the risks of DNA damage, spindle configuration, embryonic aneuploidy, and genomic imprinting as compared with fresh and slow-freezing procedures, respectively.

Conclusions: Both embryo and oocyte vitrifications are safe applications in female fertility preservation.

语种: 英语
所属项目编号: 31230047 ; 81200470 ; 2011CB944503 ; 2011CB944504
项目资助者: National Natural Science Foundation of China ; National Basic Research Program of China
WOS记录号: WOS:000349523200018
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63438
Appears in Collections:北京大学第三临床医学院_期刊论文

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作者单位: Peking Univ, Hosp 3, Ctr Reprod Med,Minist Educ, Dept Obstet & Gynecol,Key Lab Assisted Reprod,Bei, Beijing 100191, Peoples R China

Recommended Citation:
Zhang, Lu,Yan, Li-Ying,Zhi, Xu,et al. Female Fertility: Is it Safe to "Freeze?"[J]. CHINESE MEDICAL JOURNAL,2015,128(3):390-397.
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