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Differential role of Rac in the basolateral amygdala and cornu ammonis 1 in the reconsolidation of auditory and contextual Pavlovian fear memory in rats
Wu, Ping1; Ding, Zeng-Bo1; Meng, Shi-Qiu1; Shen, Hao-Wei1; Sun, Shi-Chao1; Luo, Yi-Xiao1; Liu, Jian-Feng1; Lu, Lin1,2; Zhu, Wei-Li1; Shi, Jie1
关键词Reconsolidation Amygdala Cornu ammonis 1 Contextual fear memory Auditory fear memory Rac
刊名PSYCHOPHARMACOLOGY
2014-08-01
DOI10.1007/s00213-014-3462-0
231期:15页:2909-2919
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences ; Pharmacology & Pharmacy ; Psychiatry
研究领域[WOS]Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry
关键词[WOS]CORTICOTROPIN-RELEASING-FACTOR ; POSTTRAUMATIC-STRESS-DISORDER ; RHO-GTPASES ; PROTEIN-SYNTHESIS ; GLUCOCORTICOID-RECEPTORS ; ASSOCIATIVE MEMORY ; SIGNALING PATHWAY ; CONDITIONED FEAR ; DRUG MEMORY ; CONSOLIDATION
英文摘要

A conditioned stimulus (CS) is associated with a fearful unconditioned stimulus (US) in the traditional fear conditioning model. After fear conditioning, the CS-US association memory undergoes the consolidation process to become stable. Consolidated memory enters an unstable state after retrieval and requires the reconsolidation process to stabilize again. Evidence indicates the important role of Rac (Ras-related C3 botulinum toxin substrate) in the acquisition and extinction of fear memory. In the present study, we hypothesized that Rac in the amygdala is crucial for the reconsolidation of auditory and contextual Pavlovian fear memory.

Auditory and contextual fear conditioning and microinjections of the Rac inhibitor NSC23766 were used to explore the role of Rac in the reconsolidation of auditory and contextual Pavlovian fear memory in rats.

A microinjection of NSC23766 into the basolateral amygdala (BLA) but not central amygdala (CeA) or cornu ammonis 1 (CA1) immediately after memory retrieval disrupted the reconsolidation of auditory Pavlovian fear memory. A microinjection of NSC23766 into the CA1 but not BLA or CeA after memory retrieval disrupted the reconsolidation of contextual Pavlovian fear memory.

Our experiments demonstrate that Rac in the BLA is crucial for the reconsolidation of auditory Pavlovian fear memory, whereas Rac in the CA1 is critical for the reconsolidation of contextual Pavlovian fear memory.

语种英语
WOS记录号WOS:000339898000001
项目编号81201032 ; 31230033 ; 8H1225009
资助机构Natural Science Foundation of China
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63440
专题北京大学医学部管理机构_医学部
中国药物依赖性研究所
作者单位1.Peking Univ, Inst Mental Hlth, Beijing 100191, Peoples R China
2.Peking Univ, Natl Inst Drug Dependence, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Wu, Ping,Ding, Zeng-Bo,Meng, Shi-Qiu,et al. Differential role of Rac in the basolateral amygdala and cornu ammonis 1 in the reconsolidation of auditory and contextual Pavlovian fear memory in rats[J]. PSYCHOPHARMACOLOGY,2014,231(15):2909-2919.
APA Wu, Ping.,Ding, Zeng-Bo.,Meng, Shi-Qiu.,Shen, Hao-Wei.,Sun, Shi-Chao.,...&Shi, Jie.(2014).Differential role of Rac in the basolateral amygdala and cornu ammonis 1 in the reconsolidation of auditory and contextual Pavlovian fear memory in rats.PSYCHOPHARMACOLOGY,231(15),2909-2919.
MLA Wu, Ping,et al."Differential role of Rac in the basolateral amygdala and cornu ammonis 1 in the reconsolidation of auditory and contextual Pavlovian fear memory in rats".PSYCHOPHARMACOLOGY 231.15(2014):2909-2919.
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