IR@PKUHSC  > 北京大学第二临床医学院  > 肝胆外科
学科主题临床医学
Reduced survival of patients with hepatocellular carcinoma expressing hexokinase II
Gong, Lei; Cui, Zhuqingqing; Chen, Pengcheng; Han, Hui; Peng, Jirun; Leng, Xisheng
关键词Hepatocellular carcinoma Hexokinase II Prognosis Therapeutic target
刊名MEDICAL ONCOLOGY
2012-06-01
DOI10.1007/s12032-011-9841-z
29期:2页:909-914
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]HYPOXIA-INDUCIBLE FACTOR-1-ALPHA ; HEPATOMA-CELL LINE ; CANCER-CELLS ; ENERGY-METABOLISM ; PANCREATIC-CANCER ; MITOCHONDRIA ; 3-BROMOPYRUVATE ; GLYCOLYSIS ; INHIBITOR ; ISOZYMES
英文摘要

Hexokinase II is a key enzyme in the glycolytic pathway and possesses anti-apoptotic properties in tumor cells. The present study aimed to analyze the expression of hexokinase II and its clinical correlation with clinical factors in patients with hepatocellular carcinoma who treated surgically in China. Reverse transcription-polymerase chain reaction and real-time quantitative polymerase chain reaction were performed to determine hexokinase II mRNA expression in cancer tissues. Protein expression of hexokinase II was evaluated immunohistochemically. Correlation of hexokinase II expression with clinical data was analyzed by the chi(2) or Fisher exact test. Survival was estimated by the Kaplan-Meier method, compared by log-rank test and Cox regression model. A total of 97 specimens were analyzed. Fifty-four tumors showed strong expression of hexokinase II (55.67% expression rate). There were no statistical associations between hexokinase II expression and age, gender, tumor size, TNM stage, serum AFP level, and hepatitis virus infection. Kaplan-Meier curves showed an association between positive Hexokinase II expression and worse overall survival (P value = 0.043). Furthermore, patients expressing hexokinase II had a relatively higher risk for poor prognosis (hazard ratio = 2.049). These results suggest that hexokinase II is highly expressed in hepatocellular carcinoma and has prognostic significance. Hexokinase II represents a potential new therapeutic target in this malignancy.

语种英语
WOS记录号WOS:000303539000079
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被引频次:16[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63441
专题北京大学第二临床医学院_肝胆外科
作者单位Peking Univ, Dept Hepatobiliary Surg, Peoples Hosp, Beijing 100044, Peoples R China
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Gong, Lei,Cui, Zhuqingqing,Chen, Pengcheng,et al. Reduced survival of patients with hepatocellular carcinoma expressing hexokinase II[J]. MEDICAL ONCOLOGY,2012,29(2):909-914.
APA Gong, Lei,Cui, Zhuqingqing,Chen, Pengcheng,Han, Hui,Peng, Jirun,&Leng, Xisheng.(2012).Reduced survival of patients with hepatocellular carcinoma expressing hexokinase II.MEDICAL ONCOLOGY,29(2),909-914.
MLA Gong, Lei,et al."Reduced survival of patients with hepatocellular carcinoma expressing hexokinase II".MEDICAL ONCOLOGY 29.2(2012):909-914.
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